1ILR

CRYSTAL STRUCTURE OF THE INTERLEUKIN-1 RECEPTOR ANTAGONIST

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005125	molecular_function	cytokine activity
1	0005149	molecular_function	interleukin-1 receptor binding
1	0005150	molecular_function	interleukin-1, type I receptor binding
1	0005151	molecular_function	interleukin-1, type II receptor binding
1	0005152	molecular_function	interleukin-1 receptor antagonist activity
1	0005515	molecular_function	protein binding
1	0005576	cellular_component	extracellular region
1	0005615	cellular_component	extracellular space
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005886	cellular_component	plasma membrane
1	0006954	biological_process	inflammatory response
1	0006955	biological_process	immune response
1	0007165	biological_process	signal transduction
1	0031982	cellular_component	vesicle
1	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
1	0045352	molecular_function	interleukin-1 type I receptor antagonist activity
1	0045353	molecular_function	interleukin-1 type II receptor antagonist activity
1	0050728	biological_process	negative regulation of inflammatory response
1	0051384	biological_process	response to glucocorticoid
1	0070062	cellular_component	extracellular exosome
1	2000660	biological_process	negative regulation of interleukin-1-mediated signaling pathway
2	0005125	molecular_function	cytokine activity
2	0005149	molecular_function	interleukin-1 receptor binding
2	0005150	molecular_function	interleukin-1, type I receptor binding
2	0005151	molecular_function	interleukin-1, type II receptor binding
2	0005152	molecular_function	interleukin-1 receptor antagonist activity
2	0005515	molecular_function	protein binding
2	0005576	cellular_component	extracellular region
2	0005615	cellular_component	extracellular space
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005886	cellular_component	plasma membrane
2	0006954	biological_process	inflammatory response
2	0006955	biological_process	immune response
2	0007165	biological_process	signal transduction
2	0031982	cellular_component	vesicle
2	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
2	0045352	molecular_function	interleukin-1 type I receptor antagonist activity
2	0045353	molecular_function	interleukin-1 type II receptor antagonist activity
2	0050728	biological_process	negative regulation of inflammatory response
2	0051384	biological_process	response to glucocorticoid
2	0070062	cellular_component	extracellular exosome
2	2000660	biological_process	negative regulation of interleukin-1-mediated signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00253
Number of Residues	21
Details	INTERLEUKIN_1 Interleukin-1 signature. FeSAacPgwFLCTameadqpV

Chain	Residue	Details
1	PHE111-VAL131

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2137200","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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