1ILP

CXCR-1 N-TERMINAL PEPTIDE BOUND TO INTERLEUKIN-8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0002237	biological_process	response to molecule of bacterial origin
A	0005125	molecular_function	cytokine activity
A	0005153	molecular_function	interleukin-8 receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006935	biological_process	chemotaxis
A	0006952	biological_process	defense response
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008009	molecular_function	chemokine activity
A	0008201	molecular_function	heparin binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0010628	biological_process	positive regulation of gene expression
A	0010629	biological_process	negative regulation of gene expression
A	0016020	cellular_component	membrane
A	0019722	biological_process	calcium-mediated signaling
A	0030155	biological_process	regulation of cell adhesion
A	0030593	biological_process	neutrophil chemotaxis
A	0031623	biological_process	receptor internalization
A	0034976	biological_process	response to endoplasmic reticulum stress
A	0035556	biological_process	intracellular signal transduction
A	0042119	biological_process	neutrophil activation
A	0044344	biological_process	cellular response to fibroblast growth factor stimulus
A	0045091	biological_process	regulation of single stranded viral RNA replication via double stranded DNA intermediate
A	0045236	molecular_function	CXCR chemokine receptor binding
A	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
A	0045766	biological_process	positive regulation of angiogenesis
A	0048566	biological_process	embryonic digestive tract development
A	0050930	biological_process	induction of positive chemotaxis
A	0060354	biological_process	negative regulation of cell adhesion molecule production
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071347	biological_process	cellular response to interleukin-1
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0090023	biological_process	positive regulation of neutrophil chemotaxis
A	2000535	biological_process	regulation of entry of bacterium into host cell
B	0001525	biological_process	angiogenesis
B	0002237	biological_process	response to molecule of bacterial origin
B	0005125	molecular_function	cytokine activity
B	0005153	molecular_function	interleukin-8 receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006935	biological_process	chemotaxis
B	0006952	biological_process	defense response
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0008009	molecular_function	chemokine activity
B	0008201	molecular_function	heparin binding
B	0008285	biological_process	negative regulation of cell population proliferation
B	0010628	biological_process	positive regulation of gene expression
B	0010629	biological_process	negative regulation of gene expression
B	0016020	cellular_component	membrane
B	0019722	biological_process	calcium-mediated signaling
B	0030155	biological_process	regulation of cell adhesion
B	0030593	biological_process	neutrophil chemotaxis
B	0031623	biological_process	receptor internalization
B	0034976	biological_process	response to endoplasmic reticulum stress
B	0035556	biological_process	intracellular signal transduction
B	0042119	biological_process	neutrophil activation
B	0044344	biological_process	cellular response to fibroblast growth factor stimulus
B	0045091	biological_process	regulation of single stranded viral RNA replication via double stranded DNA intermediate
B	0045236	molecular_function	CXCR chemokine receptor binding
B	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
B	0045766	biological_process	positive regulation of angiogenesis
B	0048566	biological_process	embryonic digestive tract development
B	0050930	biological_process	induction of positive chemotaxis
B	0060354	biological_process	negative regulation of cell adhesion molecule production
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0071222	biological_process	cellular response to lipopolysaccharide
B	0071347	biological_process	cellular response to interleukin-1
B	0071356	biological_process	cellular response to tumor necrosis factor
B	0090023	biological_process	positive regulation of neutrophil chemotaxis
B	2000535	biological_process	regulation of entry of bacterium into host cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NH2 C 18

Chain	Residue
A	GLN8
C	PRO17

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Functional Information from PROSITE/UniProt

site_id	PS00471
Number of Residues	46
Details	SMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CqCIktyskpFhpKfIkeLrviesGphCantEIIvklsdgrel.CLD

Chain	Residue	Details
A	CYS7-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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