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1IKM

NMR study of monomeric human interleukin-8 (30 structures)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0002237biological_processresponse to molecule of bacterial origin
A0005125molecular_functioncytokine activity
A0005153molecular_functioninterleukin-8 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006935biological_processchemotaxis
A0006952biological_processdefense response
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0008009molecular_functionchemokine activity
A0008201molecular_functionheparin binding
A0008285biological_processnegative regulation of cell population proliferation
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0019722biological_processcalcium-mediated signaling
A0030155biological_processregulation of cell adhesion
A0030593biological_processneutrophil chemotaxis
A0031328biological_processpositive regulation of cellular biosynthetic process
A0031623biological_processreceptor internalization
A0034976biological_processresponse to endoplasmic reticulum stress
A0035556biological_processintracellular signal transduction
A0042119biological_processneutrophil activation
A0044344biological_processcellular response to fibroblast growth factor stimulus
A0045091biological_processregulation of single stranded viral RNA replication via double stranded DNA intermediate
A0045236molecular_functionCXCR chemokine receptor binding
A0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
A0045766biological_processpositive regulation of angiogenesis
A0048566biological_processembryonic digestive tract development
A0050930biological_processinduction of positive chemotaxis
A0060354biological_processnegative regulation of cell adhesion molecule production
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A0070098biological_processchemokine-mediated signaling pathway
A0071222biological_processcellular response to lipopolysaccharide
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0090023biological_processpositive regulation of neutrophil chemotaxis
A2000535biological_processregulation of entry of bacterium into host cell
Functional Information from PROSITE/UniProt
site_idPS00471
Number of Residues46
DetailsSMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CqCIktyskpFhpKfIkeLrviesGphCantEIIvklsdgrel.CLD
ChainResidueDetails
ACYS7-ASP52

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by MMP9
ChainResidueDetails
ASER1

221051

PDB entries from 2024-06-12

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