1IGA
MODEL OF HUMAN IGA1 DETERMINED BY SOLUTION SCATTERING CURVE-FITTING AND HOMOLOGY MODELLING
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001895 | biological_process | retina homeostasis |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0002376 | biological_process | immune system process |
| A | 0003094 | biological_process | glomerular filtration |
| A | 0003823 | molecular_function | antigen binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0019814 | cellular_component | immunoglobulin complex |
| A | 0034987 | molecular_function | immunoglobulin receptor binding |
| A | 0050853 | biological_process | B cell receptor signaling pathway |
| A | 0060267 | biological_process | positive regulation of respiratory burst |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071735 | cellular_component | IgG immunoglobulin complex |
| A | 0071745 | cellular_component | IgA immunoglobulin complex |
| A | 0071748 | cellular_component | monomeric IgA immunoglobulin complex |
| A | 0071751 | cellular_component | secretory IgA immunoglobulin complex |
| A | 0071752 | cellular_component | secretory dimeric IgA immunoglobulin complex |
| A | 0072562 | cellular_component | blood microparticle |
| B | 0001895 | biological_process | retina homeostasis |
| B | 0002250 | biological_process | adaptive immune response |
| B | 0002376 | biological_process | immune system process |
| B | 0003094 | biological_process | glomerular filtration |
| B | 0003823 | molecular_function | antigen binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
| B | 0019731 | biological_process | antibacterial humoral response |
| B | 0019814 | cellular_component | immunoglobulin complex |
| B | 0034987 | molecular_function | immunoglobulin receptor binding |
| B | 0050853 | biological_process | B cell receptor signaling pathway |
| B | 0060267 | biological_process | positive regulation of respiratory burst |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071735 | cellular_component | IgG immunoglobulin complex |
| B | 0071745 | cellular_component | IgA immunoglobulin complex |
| B | 0071748 | cellular_component | monomeric IgA immunoglobulin complex |
| B | 0071751 | cellular_component | secretory IgA immunoglobulin complex |
| B | 0071752 | cellular_component | secretory dimeric IgA immunoglobulin complex |
| B | 0072562 | cellular_component | blood microparticle |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| C | TYR192-HIS198 | |
| A | PHE433-HIS439 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 184 |
| Details | Domain: {"description":"Ig-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 190 |
| Details | Domain: {"description":"Ig-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 204 |
| Details | Domain: {"description":"Ig-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 52 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | Compositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) serine","evidences":[{"source":"PubMed","id":"4373463","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"20823119","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31959827","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) serine","evidences":[{"source":"PubMed","id":"20823119","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31959827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4373463","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"31959827","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
