1IG8
Crystal Structure of Yeast Hexokinase PII with the correct amino acid sequence
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001678 | biological_process | intracellular glucose homeostasis |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004340 | molecular_function | glucokinase activity |
| A | 0004396 | molecular_function | hexokinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005536 | molecular_function | D-glucose binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006000 | biological_process | fructose metabolic process |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006013 | biological_process | mannose metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0008361 | biological_process | regulation of cell size |
| A | 0008865 | molecular_function | fructokinase activity |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0019158 | molecular_function | mannokinase activity |
| A | 0019318 | biological_process | hexose metabolic process |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0046015 | biological_process | regulation of transcription by glucose |
| A | 0046835 | biological_process | carbohydrate phosphorylation |
| A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| A | 1990539 | biological_process | fructose import across plasma membrane |
| A | 2001234 | biological_process | negative regulation of apoptotic signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | THR234 |
| A | GLY418 |
| A | SER419 |
| A | HOH650 |
| A | HOH874 |
Functional Information from PROSITE/UniProt
| site_id | PS00378 |
| Number of Residues | 26 |
| Details | HEXOKINASE_1 Hexokinase domain signature. LGFTFSFPasqnkINegiLqrWTKgF |
| Chain | Residue | Details |
| A | LEU153-PHE178 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 448 |
| Details | Domain: {"description":"Hexokinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 134 |
| Details | Region: {"description":"Hexokinase small subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 248 |
| Details | Region: {"description":"Hexokinase large subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9047292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P04806","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | a catalytic site defined by CSA, PubMed 2005085, 10749890 |
| Chain | Residue | Details |
| A | ASP211 | |
| A | SER158 | |
| A | ARG173 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 651 |
| Chain | Residue | Details |
| A | SER158 | electrostatic stabiliser |
| A | ARG173 | electrostatic stabiliser |
| A | ASP211 | proton shuttle (general acid/base) |
