1IG3
Mouse Thiamin Pyrophosphokinase Complexed with Thiamin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004788 | molecular_function | thiamine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006772 | biological_process | thiamine metabolic process |
| A | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| A | 0010510 | biological_process | regulation of acetyl-CoA biosynthetic process from pyruvate |
| A | 0016301 | molecular_function | kinase activity |
| A | 0030975 | molecular_function | thiamine binding |
| A | 0042723 | biological_process | thiamine-containing compound metabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0141200 | molecular_function | UTP thiamine diphosphokinase activity |
| B | 0004788 | molecular_function | thiamine diphosphokinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006772 | biological_process | thiamine metabolic process |
| B | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| B | 0010510 | biological_process | regulation of acetyl-CoA biosynthetic process from pyruvate |
| B | 0016301 | molecular_function | kinase activity |
| B | 0030975 | molecular_function | thiamine binding |
| B | 0042723 | biological_process | thiamine-containing compound metabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0141200 | molecular_function | UTP thiamine diphosphokinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | GLY78 |
| A | GLU79 |
| A | ARG80 |
| A | HOH691 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 603 |
| Chain | Residue |
| A | LYS105 |
| A | LYS106 |
| A | HOH753 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 604 |
| Chain | Residue |
| A | THR119 |
| A | THR122 |
| A | ASN160 |
| A | GLN164 |
| A | HOH650 |
| A | ASP117 |
| A | HIS118 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 605 |
| Chain | Residue |
| A | ASN45 |
| A | HOH668 |
| A | HOH745 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 606 |
| Chain | Residue |
| B | GLY78 |
| B | GLU79 |
| B | ARG80 |
| B | TYR102 |
| B | HOH761 |
| B | HOH809 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 607 |
| Chain | Residue |
| B | HIS118 |
| B | THR119 |
| B | THR122 |
| B | ASN160 |
| B | THR161 |
| B | GLN164 |
| B | HOH617 |
| B | HOH698 |
| B | HOH786 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 608 |
| Chain | Residue |
| B | ASN45 |
| B | HOH635 |
| B | HOH677 |
| B | HOH708 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 609 |
| Chain | Residue |
| A | SER238 |
| A | VIB502 |
| B | ARG151 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 610 |
| Chain | Residue |
| A | ARG151 |
| A | HOH752 |
| B | SER238 |
| B | VIB501 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 611 |
| Chain | Residue |
| B | GLY200 |
| B | SER201 |
| B | LYS262 |
| B | SER263 |
| B | HOH644 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 612 |
| Chain | Residue |
| A | GLY200 |
| A | SER201 |
| A | LYS262 |
| A | SER263 |
| A | HOH623 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 613 |
| Chain | Residue |
| A | GLN46 |
| A | GLY150 |
| A | HOH648 |
| A | HOH713 |
| A | HOH715 |
| A | HOH729 |
| A | HOH772 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 615 |
| Chain | Residue |
| B | ALA24 |
| B | ARG191 |
| B | HIS193 |
| B | HOH781 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 616 |
| Chain | Residue |
| A | ASN213 |
| A | HIS253 |
| A | HOH676 |
| A | HOH747 |
| A | HOH756 |
| B | PRO33 |
| B | GLY35 |
| B | LYS58 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE VIB B 501 |
| Chain | Residue |
| A | GLN116 |
| A | ASP117 |
| A | SO4610 |
| B | TRP222 |
| B | SER236 |
| B | THR237 |
| B | SER238 |
| B | ASN239 |
| B | HOH616 |
| site_id | BC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE VIB A 502 |
| Chain | Residue |
| A | TRP222 |
| A | SER236 |
| A | THR237 |
| A | SER238 |
| A | ASN239 |
| A | SO4609 |
| A | HOH631 |
| A | HOH644 |
| B | GLN116 |
| B | ASP117 |
| B | HIS118 |
| B | HOH786 |
