1IG1

1.8A X-Ray structure of ternary complex of a catalytic domain of death-associated protein kinase with ATP analogue and Mn.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 3510

Chain	Residue
A	ASN144
A	ASP161
A	ANP300
A	HOH2510
A	HOH3525

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ANP A 300

Chain	Residue
A	ALA40
A	LYS42
A	GLU94
A	VAL96
A	GLU100
A	GLU143
A	ASN144
A	MET146
A	ILE160
A	ASP161
A	HOH2001
A	HOH2510
A	HOH2511
A	HOH3400
A	MN3510
A	LEU19
A	GLY20
A	GLY22
A	VAL27

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGQFAVVKkCrekstglqyaak......FIKK

Chain	Residue	Details
A	LEU19-LYS46

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHfDLKpeNIML

Chain	Residue	Details
A	ILE135-LEU147

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP139

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	LYS42
A	GLU94
A	GLU100
A	ASP161
A	LEU19

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by RPS6KA1 and RPS6KA3 => ECO:0000269|PubMed:16213824

Chain	Residue	Details
A	SER289

---