1IEC
CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT (H157A) OF THE HUMAN CYTOMEGALOVIRUS PROTEASE
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"HAMAP-Rule","id":"MF_04008","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8805706","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"HAMAP-Rule","id":"MF_04008","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by assemblin; Cryptic site","evidences":[{"source":"PubMed","id":"12163586","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details |
| Chain | Residue | Details |
| A | ARG166 | |
| A | SER134 | |
| A | HIS63 | |
| A | ALA157 | |
| A | ARG165 | |
| A | SEB132 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details |
| Chain | Residue | Details |
| A | ARG166 | |
| A | SER134 | |
| A | HIS63 | |
| A | ALA157 | |
| A | ARG165 | |
| A | SEB132 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details |
| Chain | Residue | Details |
| B | ARG465 | |
| B | ARG466 | |
| B | HIS363 | |
| B | ALA457 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 238 |
| Chain | Residue | Details |
| A | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | SEB132 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | CYS161 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity |
| A | THR169 | electrostatic stabiliser, hydrogen bond donor |
| A | LEU170 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 238 |
| Chain | Residue | Details |
| B | HIS363 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | SEB432 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | CYS461 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity |
| B | THR469 | electrostatic stabiliser, hydrogen bond donor |
| B | LEU470 | electrostatic stabiliser, hydrogen bond donor |
