1IDS

X-RAY STRUCTURE ANALYSIS OF THE IRON-DEPENDENT SUPEROXIDE DISMUTASE FROM MYCOBACTERIUM TUBERCULOSIS AT 2.0 ANGSTROMS RESOLUTIONS REVEALS NOVEL DIMER-DIMER INTERACTIONS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004784	molecular_function	superoxide dismutase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006801	biological_process	superoxide metabolic process
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding
A	0098754	biological_process	detoxification
B	0004784	molecular_function	superoxide dismutase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006801	biological_process	superoxide metabolic process
B	0006979	biological_process	response to oxidative stress
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0042597	cellular_component	periplasmic space
B	0046872	molecular_function	metal ion binding
B	0098754	biological_process	detoxification
C	0004784	molecular_function	superoxide dismutase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006801	biological_process	superoxide metabolic process
C	0006979	biological_process	response to oxidative stress
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0042597	cellular_component	periplasmic space
C	0046872	molecular_function	metal ion binding
C	0098754	biological_process	detoxification
D	0004784	molecular_function	superoxide dismutase activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006801	biological_process	superoxide metabolic process
D	0006979	biological_process	response to oxidative stress
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0042597	cellular_component	periplasmic space
D	0046872	molecular_function	metal ion binding
D	0098754	biological_process	detoxification

Functional Information from PDB Data

site_id	A1
Number of Residues	1
Details	CATALYTIC SITE OF CHAIN A

Chain	Residue
A	FE208

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site_id	A2
Number of Residues	1
Details	CATALYTIC SITE OF CHAIN B

Chain	Residue
B	FE208

---

site_id	A3
Number of Residues	1
Details	CATALYTIC SITE OF CHAIN C

Chain	Residue
C	FE208

---

site_id	A4
Number of Residues	1
Details	CATALYTIC SITE OF CHAIN D

Chain	Residue
D	FE208

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site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE A 208

Chain	Residue
A	HIS28
A	HIS76
A	ASP160
A	HIS164
A	HOH1001

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE B 208

Chain	Residue
B	HIS28
B	HIS76
B	ASP160
B	HIS164
B	HOH1002

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE C 208

Chain	Residue
C	HIS28
C	HIS76
C	ASP160
C	HIS164
C	HOH1003

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE D 208

Chain	Residue
D	HIS28
D	HIS76
D	ASP160
D	HIS164
D	HOH1004

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Functional Information from PROSITE/UniProt

site_id	PS00088
Number of Residues	8
Details	SOD_MN Manganese and iron superoxide dismutases signature. DmWEHAFY

Chain	Residue	Details
A	ASP160-TYR167

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:11747311, ECO:0000269|PubMed:7877174, ECO:0000269|PubMed:8674528, ECO:0000269|PubMed:9490054, ECO:0007744|PDB:1GN2, ECO:0007744|PDB:1GN3, ECO:0007744|PDB:1GN6, ECO:0007744|PDB:1IDS

Chain	Residue	Details
A	HIS28
C	HIS76
C	ASP160
C	HIS164
D	HIS28
D	HIS76
D	ASP160
D	HIS164
A	HIS76
A	ASP160
A	HIS164
B	HIS28
B	HIS76
B	ASP160
B	HIS164
C	HIS28

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site_id	SWS_FT_FI2
Number of Residues	8
Details	CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) => ECO:0000269|PubMed:20066036

Chain	Residue	Details
A	LYS202
B	LYS202
C	LYS202
D	LYS202

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