1IDC

ISOCITRATE DEHYDROGENASE FROM E.COLI (MUTANT K230M), STEADY-STATE INTERMEDIATE COMPLEX DETERMINED BY LAUE CRYSTALLOGRAPHY

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0000287	molecular_function	magnesium ion binding
A	0004450	molecular_function	isocitrate dehydrogenase (NADP+) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006097	biological_process	glyoxylate cycle
A	0006099	biological_process	tricarboxylic acid cycle
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0022900	biological_process	electron transport chain
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
A	0097216	molecular_function	guanosine tetraphosphate binding

PDBデータベースに由来する情報

site_id	AC1
残基数	4
詳細	BINDING SITE FOR RESIDUE MG A 417

鎖名	残基
A	ASP307
A	ASP311
A	OXS418
A	ASP283

---

site_id	AC2
残基数	10
詳細	BINDING SITE FOR RESIDUE OXS A 418

鎖名	残基
A	SER113
A	ASN115
A	VAL116
A	ARG119
A	ARG153
A	TYR160
A	ILE233
A	ASP283
A	ASP307
A	MG417

---

site_id	SUB
残基数	8
詳細	ISOCITRATE/MG++ BINDING SITE

鎖名	残基
A	SER113
A	ASN115
A	ARG119
A	ARG129
A	ARG153
A	TYR160
A	ASP307
A	ASP311

---

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00470
残基数	20
詳細	IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLNGDYiSDalAaqv.GGIGI

鎖名	残基	詳細
A	ASN303-ILE322

---

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	1
詳細	Binding site: {"evidences":[{"source":"PubMed","id":"11284679","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2682654","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7761851","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJR","evidenceCode":"ECO:0007744"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI2
残基数	4
詳細	Binding site: {"evidences":[{"source":"PubMed","id":"10623532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2204109","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PB1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ICD","evidenceCode":"ECO:0007744"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI3
残基数	1
詳細	Binding site: {"evidences":[{"source":"PubMed","id":"10623532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2204109","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PB1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ICD","evidenceCode":"ECO:0007744"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI4
残基数	2
詳細	Binding site: {"evidences":[{"source":"PubMed","id":"10623532","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CW4","evidenceCode":"ECO:0007744"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI5
残基数	6
詳細	Binding site: {"evidences":[{"source":"PubMed","id":"11284679","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2682654","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7761851","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BL5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ISO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9ICD","evidenceCode":"ECO:0007744"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI6
残基数	2
詳細	Binding site: {"evidences":[{"source":"PubMed","id":"11284679","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2682654","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7761851","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BL5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AJR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9ICD","evidenceCode":"ECO:0007744"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI7
残基数	1
詳細	Binding site: {"evidences":[{"source":"PubMed","id":"11284679","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2682654","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7761851","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9ICD","evidenceCode":"ECO:0007744"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI8
残基数	2
詳細	Site: {"description":"Critical for catalysis","evidences":[{"source":"PubMed","id":"7761851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7819221","evidenceCode":"ECO:0000269"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI9
残基数	2
詳細	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"21151122","evidenceCode":"ECO:0000269"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI10
残基数	1
詳細	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"2204109","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3112144","evidenceCode":"ECO:0000269"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI11
残基数	1
詳細	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

鎖名

残基

詳細

---

CSAにおける酵素触媒機能の情報

site_id	CSA1
残基数	1
詳細	Annotated By Reference To The Literature 1a05

鎖名	残基	詳細
A	TYR160

---

site_id	MCSA1
残基数	4
詳細	M-CSA 7

鎖名	残基	詳細
A	TYR160	electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay
A	MET230	electrostatic stabiliser, proton acceptor, proton donor, proton relay
A	ASP283	electrostatic stabiliser, proton acceptor, proton donor
A	ASP307	metal ligand

---