1ICU
THE STRUCTURE OF ESCHERICHIA COLI NITROREDUCTASE COMPLEXED WITH NICOTINIC ACID
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003955 | molecular_function | NAD(P)H dehydrogenase (quinone) activity |
A | 0004155 | molecular_function | 6,7-dihydropteridine reductase activity |
A | 0005829 | cellular_component | cytosol |
A | 0010181 | molecular_function | FMN binding |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0046256 | biological_process | 2,4,6-trinitrotoluene catabolic process |
A | 0046857 | molecular_function | oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor |
B | 0003955 | molecular_function | NAD(P)H dehydrogenase (quinone) activity |
B | 0004155 | molecular_function | 6,7-dihydropteridine reductase activity |
B | 0005829 | cellular_component | cytosol |
B | 0010181 | molecular_function | FMN binding |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0046256 | biological_process | 2,4,6-trinitrotoluene catabolic process |
B | 0046857 | molecular_function | oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor |
C | 0003955 | molecular_function | NAD(P)H dehydrogenase (quinone) activity |
C | 0004155 | molecular_function | 6,7-dihydropteridine reductase activity |
C | 0005829 | cellular_component | cytosol |
C | 0010181 | molecular_function | FMN binding |
C | 0016020 | cellular_component | membrane |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0042802 | molecular_function | identical protein binding |
C | 0042803 | molecular_function | protein homodimerization activity |
C | 0046256 | biological_process | 2,4,6-trinitrotoluene catabolic process |
C | 0046857 | molecular_function | oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor |
D | 0003955 | molecular_function | NAD(P)H dehydrogenase (quinone) activity |
D | 0004155 | molecular_function | 6,7-dihydropteridine reductase activity |
D | 0005829 | cellular_component | cytosol |
D | 0010181 | molecular_function | FMN binding |
D | 0016020 | cellular_component | membrane |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0042802 | molecular_function | identical protein binding |
D | 0042803 | molecular_function | protein homodimerization activity |
D | 0046256 | biological_process | 2,4,6-trinitrotoluene catabolic process |
D | 0046857 | molecular_function | oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE FMN A 218 |
Chain | Residue |
A | ARG10 |
A | GLY166 |
A | ASN200 |
A | LYS205 |
A | ARG207 |
A | HOH227 |
A | HOH241 |
A | HOH242 |
B | PRO38 |
B | SER39 |
B | SER40 |
A | HIS11 |
B | ASN42 |
B | LEU145 |
B | NIO219 |
A | SER12 |
A | LYS14 |
A | ASN71 |
A | LYS74 |
A | PRO163 |
A | ILE164 |
A | GLU165 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NIO B 219 |
Chain | Residue |
A | PHE70 |
A | GLY166 |
A | FMN218 |
B | SER40 |
B | THR41 |
B | PHE124 |
site_id | AC3 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE FMN B 220 |
Chain | Residue |
A | PRO38 |
A | SER39 |
A | SER40 |
A | ASN42 |
A | GLN142 |
A | LEU145 |
A | NIO221 |
B | ARG10 |
B | HIS11 |
B | SER12 |
B | LYS14 |
B | ASN71 |
B | LYS74 |
B | PRO163 |
B | ILE164 |
B | GLU165 |
B | GLY166 |
B | ASN200 |
B | LYS205 |
B | ARG207 |
B | HOH226 |
B | HOH241 |
B | HOH248 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NIO A 221 |
Chain | Residue |
A | SER40 |
A | THR41 |
A | PHE124 |
B | PHE70 |
B | GLY166 |
B | FMN220 |
site_id | AC5 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE FMN C 222 |
Chain | Residue |
C | ARG10 |
C | HIS11 |
C | SER12 |
C | LYS14 |
C | ASN71 |
C | LYS74 |
C | TYR144 |
C | PRO163 |
C | ILE164 |
C | GLU165 |
C | GLY166 |
C | ASN200 |
C | LYS205 |
C | ARG207 |
C | HOH234 |
C | HOH237 |
C | HOH242 |
D | PRO38 |
D | SER39 |
D | SER40 |
D | ASN42 |
D | GLN142 |
D | LEU145 |
D | NIO223 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NIO D 223 |
Chain | Residue |
C | PHE70 |
C | GLY166 |
C | FMN222 |
D | SER40 |
D | THR41 |
D | PHE124 |
site_id | AC7 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE FMN D 224 |
Chain | Residue |
D | PRO163 |
D | ILE164 |
D | GLU165 |
D | GLY166 |
D | LYS205 |
D | ARG207 |
D | HOH237 |
D | HOH239 |
D | HOH250 |
C | PRO38 |
C | SER39 |
C | SER40 |
C | ASN42 |
C | LEU145 |
C | NIO225 |
D | ARG10 |
D | HIS11 |
D | SER12 |
D | LYS14 |
D | ASN71 |
D | LYS74 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NIO C 225 |
Chain | Residue |
C | SER40 |
C | THR41 |
C | PHE124 |
D | FMN224 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11020276, ECO:0000269|PubMed:11491290, ECO:0000269|PubMed:15684426 |
Chain | Residue | Details |
A | ARG10 | |
D | ARG10 | |
D | GLU165 | |
D | LYS205 | |
A | GLU165 | |
A | LYS205 | |
B | ARG10 | |
B | GLU165 | |
B | LYS205 | |
C | ARG10 | |
C | GLU165 | |
C | LYS205 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q01234 |
Chain | Residue | Details |
A | LYS14 | |
B | ARG107 | |
C | LYS14 | |
C | THR41 | |
C | ASN71 | |
C | LYS74 | |
C | ARG107 | |
D | LYS14 | |
D | THR41 | |
D | ASN71 | |
D | LYS74 | |
A | THR41 | |
D | ARG107 | |
A | ASN71 | |
A | LYS74 | |
A | ARG107 | |
B | LYS14 | |
B | THR41 | |
B | ASN71 | |
B | LYS74 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 211 |
Chain | Residue | Details |
A | LYS14 | electrostatic stabiliser, hydrogen bond donor |
A | LYS74 | electrostatic stabiliser, hydrogen bond donor |
A | GLU165 | electrostatic stabiliser, hydrogen bond donor |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 211 |
Chain | Residue | Details |
B | LYS14 | electrostatic stabiliser, hydrogen bond donor |
B | LYS74 | electrostatic stabiliser, hydrogen bond donor |
B | GLU165 | electrostatic stabiliser, hydrogen bond donor |
site_id | MCSA3 |
Number of Residues | 3 |
Details | M-CSA 211 |
Chain | Residue | Details |
C | LYS14 | electrostatic stabiliser, hydrogen bond donor |
C | LYS74 | electrostatic stabiliser, hydrogen bond donor |
C | GLU165 | electrostatic stabiliser, hydrogen bond donor |
site_id | MCSA4 |
Number of Residues | 3 |
Details | M-CSA 211 |
Chain | Residue | Details |
D | LYS14 | electrostatic stabiliser, hydrogen bond donor |
D | LYS74 | electrostatic stabiliser, hydrogen bond donor |
D | GLU165 | electrostatic stabiliser, hydrogen bond donor |