1IBV
STRUCTURE OF THE D53,54N MUTANT OF HISTIDINE DECARBOXYLASE BOUND WITH HISTIDINE METHYL ESTER AT-170 C
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004398 | molecular_function | histidine decarboxylase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006547 | biological_process | L-histidine metabolic process |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0004398 | molecular_function | histidine decarboxylase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006547 | biological_process | L-histidine metabolic process |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0004398 | molecular_function | histidine decarboxylase activity |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006547 | biological_process | L-histidine metabolic process |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0004398 | molecular_function | histidine decarboxylase activity |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006547 | biological_process | L-histidine metabolic process |
| D | 0016831 | molecular_function | carboxy-lyase activity |
| E | 0004398 | molecular_function | histidine decarboxylase activity |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0006547 | biological_process | L-histidine metabolic process |
| E | 0016831 | molecular_function | carboxy-lyase activity |
| F | 0004398 | molecular_function | histidine decarboxylase activity |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0006547 | biological_process | L-histidine metabolic process |
| F | 0016831 | molecular_function | carboxy-lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYR B 483 |
| Chain | Residue |
| A | SER81 |
| B | PHE484 |
| B | MET595 |
| B | PHE596 |
| B | PVH801 |
| C | ASN76 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYR D 483 |
| Chain | Residue |
| D | PHE596 |
| D | PVH801 |
| E | ASN76 |
| C | SER81 |
| D | PHE484 |
| D | MET595 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYR F 483 |
| Chain | Residue |
| A | ASN76 |
| E | SER81 |
| F | PHE484 |
| F | MET595 |
| F | PHE596 |
| F | PVH801 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PVH B 801 |
| Chain | Residue |
| A | ALA80 |
| A | SER81 |
| B | PYR483 |
| B | PHE484 |
| B | ASN555 |
| B | LYS556 |
| B | PHE596 |
| B | VAL597 |
| B | GLU598 |
| C | ASP63 |
| C | GLU66 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PVH D 801 |
| Chain | Residue |
| C | ALA80 |
| C | SER81 |
| D | PYR483 |
| D | PHE484 |
| D | LYS556 |
| D | PHE596 |
| D | VAL597 |
| D | GLU598 |
| E | ASP63 |
| E | GLU66 |
| E | HOH108 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PVH F 801 |
| Chain | Residue |
| A | ASP63 |
| A | GLU66 |
| E | ALA80 |
| E | SER81 |
| F | PYR483 |
| F | PHE484 |
| F | LYS556 |
| F | PHE596 |
| F | VAL597 |
| F | GLU598 |
| F | HOH904 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1pya |
| Chain | Residue | Details |
| A | TYR62 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1pya |
| Chain | Residue | Details |
| E | SER81 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pya |
| Chain | Residue | Details |
| A | SER81 | |
| C | TYR62 | |
| B | PHE195 | |
| B | GLU197 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pya |
| Chain | Residue | Details |
| C | SER81 | |
| D | PHE195 | |
| D | GLU197 | |
| E | TYR62 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1pya |
| Chain | Residue | Details |
| F | PHE195 | |
| F | GLU197 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 49 |
| Chain | Residue | Details |
| B | ALA600 | electrostatic stabiliser, hydrogen bond donor |
| B | VAL602 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLU66 | activator, hydrogen bond acceptor |
| A | SER81 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 49 |
| Chain | Residue | Details |
| D | ALA600 | electrostatic stabiliser, hydrogen bond donor |
| D | VAL602 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | GLU66 | activator, hydrogen bond acceptor |
| C | SER81 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 2 |
| Details | M-CSA 49 |
| Chain | Residue | Details |
| F | ALA600 | electrostatic stabiliser, hydrogen bond donor |
| F | VAL602 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| E | GLU66 | activator, hydrogen bond acceptor |
| E | SER81 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
