1IBT

STRUCTURE OF THE D53,54N MUTANT OF HISTIDINE DECARBOXYLASE AT-170 C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004398	molecular_function	histidine decarboxylase activity
A	0006520	biological_process	amino acid metabolic process
A	0006547	biological_process	L-histidine metabolic process
A	0016831	molecular_function	carboxy-lyase activity
B	0004398	molecular_function	histidine decarboxylase activity
B	0006520	biological_process	amino acid metabolic process
B	0006547	biological_process	L-histidine metabolic process
B	0016831	molecular_function	carboxy-lyase activity
C	0004398	molecular_function	histidine decarboxylase activity
C	0006520	biological_process	amino acid metabolic process
C	0006547	biological_process	L-histidine metabolic process
C	0016831	molecular_function	carboxy-lyase activity
D	0004398	molecular_function	histidine decarboxylase activity
D	0006520	biological_process	amino acid metabolic process
D	0006547	biological_process	L-histidine metabolic process
D	0016831	molecular_function	carboxy-lyase activity
E	0004398	molecular_function	histidine decarboxylase activity
E	0006520	biological_process	amino acid metabolic process
E	0006547	biological_process	L-histidine metabolic process
E	0016831	molecular_function	carboxy-lyase activity
F	0004398	molecular_function	histidine decarboxylase activity
F	0006520	biological_process	amino acid metabolic process
F	0006547	biological_process	L-histidine metabolic process
F	0016831	molecular_function	carboxy-lyase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Proton donor"}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1pya

Chain	Residue	Details
A	TYR62

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1pya

Chain	Residue	Details
E	SER81

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1pya

Chain	Residue	Details
A	SER81
C	TYR62
B	PHE195
B	GLU197

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1pya

Chain	Residue	Details
C	SER81
D	PHE195
D	GLU197
E	TYR62

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1pya

Chain	Residue	Details
F	PHE195
F	GLU197

---

site_id	MCSA1
Number of Residues	2
Details	M-CSA 49

Chain	Residue	Details
B	ALA199	electrostatic stabiliser, hydrogen bond donor
B	VAL201	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	GLU66	activator, hydrogen bond acceptor
A	SER81	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

---

site_id	MCSA2
Number of Residues	2
Details	M-CSA 49

Chain	Residue	Details
D	ALA199	electrostatic stabiliser, hydrogen bond donor
D	VAL201	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
C	GLU66	activator, hydrogen bond acceptor
C	SER81	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

---

site_id	MCSA3
Number of Residues	2
Details	M-CSA 49

Chain	Residue	Details
F	ALA199	electrostatic stabiliser, hydrogen bond donor
F	VAL201	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
E	GLU66	activator, hydrogen bond acceptor
E	SER81	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

---