1IB9

SOLUTION STRUCTURE OF MCOTI-II, A MACROCYCLIC TRYPSIN INHIBITOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004866	molecular_function	endopeptidase inhibitor activity
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005576	cellular_component	extracellular region
A	0006952	biological_process	defense response
A	0030414	molecular_function	peptidase inhibitor activity

Functional Information from PROSITE/UniProt

site_id	PS00286
Number of Residues	20
Details	SQUASH_INHIBITOR Squash family of serine protease inhibitors signature. CPkilkkCrrDsDCpgaCiC

Chain	Residue	Details
A	CYS8-CYS27

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	Peptide: {"description":"Trypsin inhibitor 2","featureId":"PRO_0000044858"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Reactive bond"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Cyclopeptide (Ser-Gly)","evidences":[{"source":"PubMed","id":"10801322","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Isoaspartyl glycine isopeptide (Asp-Gly); alternate","evidences":[{"source":"PubMed","id":"10801322","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---