1IAS
CYTOPLASMIC DOMAIN OF UNPHOSPHORYLATED TYPE I TGF-BETA RECEPTOR CRYSTALLIZED WITHOUT FKBP12
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| C | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| C | 0016020 | cellular_component | membrane |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
| D | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| D | 0016020 | cellular_component | membrane |
| E | 0004672 | molecular_function | protein kinase activity |
| E | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006468 | biological_process | protein phosphorylation |
| E | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| E | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 1 |
| Chain | Residue |
| E | HIS283 |
| E | LYS342 |
| E | LYS343 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2 |
| Chain | Residue |
| E | LYS337 |
| E | ARG377 |
| E | SER434 |
| E | ASP435 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 4 |
| Chain | Residue |
| C | LYS223 |
| C | GLN208 |
| C | ARG221 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 5 |
| Chain | Residue |
| C | LYS337 |
| C | ARG377 |
| C | ASP435 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 6 |
| Chain | Residue |
| B | TYR282 |
| B | HIS283 |
| B | LYS342 |
| B | LYS343 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 9 |
| Chain | Residue |
| A | TYR282 |
| A | HIS283 |
| A | LYS342 |
| A | LYS343 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 10 |
| Chain | Residue |
| C | TYR282 |
| C | HIS283 |
| C | LYS342 |
| C | LYS343 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 11 |
| Chain | Residue |
| B | ARG221 |
| B | LYS223 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 12 |
| Chain | Residue |
| B | LYS337 |
| B | ARG377 |
| B | LEU426 |
| B | ASP435 |
| B | PRO436 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 13 |
| Chain | Residue |
| D | TYR282 |
| D | HIS283 |
| D | LYS342 |
| D | LYS343 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 14 |
| Chain | Residue |
| D | LYS337 |
| D | ARG377 |
| D | LEU426 |
| D | ASP435 |
| D | PRO436 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 15 |
| Chain | Residue |
| D | ARG221 |
| D | LYS223 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 18 |
| Chain | Residue |
| A | ARG221 |
| A | LYS223 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 E 20 |
| Chain | Residue |
| E | ARG221 |
| E | LYS223 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 21 |
| Chain | Residue |
| A | LYS337 |
| A | ARG377 |
| A | LEU426 |
| A | SER434 |
| A | ASP435 |
| A | PRO436 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 22 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGRFGEVWrGkwrgee............VAVK |
| Chain | Residue | Details |
| A | ILE211-LYS232 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKskNILV |
| Chain | Residue | Details |
| A | ILE329-VAL341 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
| Chain | Residue | Details |
| A | ASP333 | |
| B | ASP333 | |
| C | ASP333 | |
| D | ASP333 | |
| E | ASP333 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | ILE211 | |
| E | LYS232 | |
| A | LYS232 | |
| B | ILE211 | |
| B | LYS232 | |
| C | ILE211 | |
| C | LYS232 | |
| D | ILE211 | |
| D | LYS232 | |
| E | ILE211 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | SER165 | |
| B | SER165 | |
| C | SER165 | |
| D | SER165 | |
| E | SER165 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine; by TGFBR2 => ECO:0000269|PubMed:7774578 |
| Chain | Residue | Details |
| A | THR185 | |
| E | THR186 | |
| A | THR186 | |
| B | THR185 | |
| B | THR186 | |
| C | THR185 | |
| C | THR186 | |
| D | THR185 | |
| D | THR186 | |
| E | THR185 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 15 |
| Details | MOD_RES: Phosphoserine; by TGFBR2 => ECO:0000269|PubMed:7774578 |
| Chain | Residue | Details |
| A | SER187 | |
| D | SER187 | |
| D | SER189 | |
| D | SER191 | |
| E | SER187 | |
| E | SER189 | |
| E | SER191 | |
| A | SER189 | |
| A | SER191 | |
| B | SER187 | |
| B | SER189 | |
| B | SER191 | |
| C | SER187 | |
| C | SER189 | |
| C | SER191 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS391 | |
| B | LYS391 | |
| C | LYS391 | |
| D | LYS391 | |
| E | LYS391 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | LYS337 | |
| A | ASP333 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| E | LYS335 | |
| E | ASP333 |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | THR375 | |
| A | LYS335 | |
| A | ASP333 |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | THR375 | |
| B | LYS335 | |
| B | ASP333 |
| site_id | CSA13 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | THR375 | |
| C | LYS335 | |
| C | ASP333 |
| site_id | CSA14 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| D | THR375 | |
| D | LYS335 | |
| D | ASP333 |
| site_id | CSA15 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| E | THR375 | |
| E | LYS335 | |
| E | ASP333 |
| site_id | CSA16 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASN338 | |
| A | LYS335 | |
| A | ASP333 |
| site_id | CSA17 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASN338 | |
| B | LYS335 | |
| B | ASP333 |
| site_id | CSA18 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | ASN338 | |
| C | LYS335 | |
| C | ASP333 |
| site_id | CSA19 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| D | ASN338 | |
| D | LYS335 | |
| D | ASP333 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | LYS337 | |
| B | ASP333 |
| site_id | CSA20 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| E | ASN338 | |
| E | LYS335 | |
| E | ASP333 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | LYS337 | |
| C | ASP333 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| D | LYS337 | |
| D | ASP333 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| E | LYS337 | |
| E | ASP333 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | LYS335 | |
| A | ASP333 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | LYS335 | |
| B | ASP333 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | LYS335 | |
| C | ASP333 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| D | LYS335 | |
| D | ASP333 |
