1IA0

KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0016787	molecular_function	hydrolase activity
A	0031514	cellular_component	motile cilium
A	0046872	molecular_function	metal ion binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
K	0003777	molecular_function	microtubule motor activity
K	0005524	molecular_function	ATP binding
K	0007018	biological_process	microtubule-based movement
K	0008017	molecular_function	microtubule binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG K 501

Chain	Residue
K	SER104
K	ACP503

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site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GTP A 500

Chain	Residue
A	GLY144
A	THR145
A	ILE171
A	SER178
A	ASN206
A	TYR224
A	LEU227
A	ASN228
A	GLN11
A	ALA12
A	GLN15
A	GLU71
A	ALA100
A	ASN101
A	GLY143

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GDP B 501

Chain	Residue
A	LEU248
B	GLN11
B	CYS12
B	GLN15
B	ILE16
B	ASN101
B	SER140
B	GLY142
B	GLY143
B	GLY144
B	THR145
B	SER178
B	TYR185
B	ASN206
B	TYR224

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE TXL B 502

Chain	Residue
B	VAL23
B	ASP26
B	LEU217
B	ASP226
B	HIS229
B	SER236
B	PHE272
B	PRO274
B	LEU275
B	THR276
B	ARG278
B	ARG320
B	PRO360
B	ARG369
B	GLY370
B	LEU371

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ACP K 503

Chain	Residue
K	ARG11
K	ARG13
K	PRO14
K	SER58
K	TYR67
K	THR99
K	GLY100
K	ALA101
K	GLY102
K	LYS103
K	SER104
K	TYR105
K	SER215
K	MG501

---

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
B	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

---

site_id	PS00411
Number of Residues	12
Details	KINESIN_MOTOR_1 Kinesin motor domain signature. SKIsLVDLAGSE

Chain	Residue	Details
K	SER242-GLU253

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
K	GLY97
B	SER140
B	GLY144
B	THR145
B	GLY146
B	ASN206
B	ASN228

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P68363

Chain	Residue	Details
B	GLU71
A	GLU71
A	SER140
A	GLY144
A	THR145
A	THR179
A	ASN206
A	ASN228

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99024

Chain	Residue	Details
B	SER40

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024

Chain	Residue	Details
B	LYS60

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000250|UniProtKB:Q13885

Chain	Residue	Details
B	SER174

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	THR287
B	THR292

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	ARG320

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q2T9S0

Chain	Residue	Details
B	GLU448

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	LYS60

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site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	LYS326

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1goj

Chain	Residue	Details
K	GLY251

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