1I9D
ARSENATE REDUCTASE FROM E. COLI
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | CYS12 |
| A | HOH719 |
| A | HOH866 |
| A | GLY13 |
| A | THR14 |
| A | ASN62 |
| A | GLU67 |
| A | SO3502 |
| A | CS610 |
| A | HOH627 |
| A | HOH675 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 403 |
| Chain | Residue |
| A | ARG107 |
| A | HOH698 |
| A | HOH711 |
| A | HOH785 |
| A | HOH792 |
| A | HOH822 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 404 |
| Chain | Residue |
| A | THR14 |
| A | ASN17 |
| A | PRO108 |
| A | SER109 |
| A | LYS126 |
| A | HOH627 |
| A | HOH695 |
| A | HOH739 |
| A | HOH766 |
| A | HOH843 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO3 A 502 |
| Chain | Residue |
| A | ARG94 |
| A | ARG107 |
| A | SO4402 |
| A | CS610 |
| A | HOH711 |
| A | HOH858 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CS A 602 |
| Chain | Residue |
| A | LEU113 |
| A | LEU113 |
| A | ASP114 |
| A | ASP114 |
| A | LEU116 |
| A | LEU116 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CS A 603 |
| Chain | Residue |
| A | GLU67 |
| A | HOH857 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS A 604 |
| Chain | Residue |
| A | PRO38 |
| A | GLU43 |
| A | HOH905 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CS A 605 |
| Chain | Residue |
| A | GLY26 |
| A | THR27 |
| A | HOH686 |
| A | HOH879 |
| A | HOH915 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CS A 606 |
| Chain | Residue |
| A | GLU64 |
| A | GLN87 |
| A | CS608 |
| A | HOH680 |
| A | HOH717 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CS A 607 |
| Chain | Residue |
| A | GLN120 |
| A | GLU135 |
| A | HOH731 |
| A | HOH782 |
| A | HOH811 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CS A 608 |
| Chain | Residue |
| A | GLU64 |
| A | CS606 |
| A | HOH733 |
| A | HOH771 |
| A | HOH973 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS A 609 |
| Chain | Residue |
| A | GLU73 |
| A | ASP128 |
| A | HOH677 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 610 |
| Chain | Residue |
| A | ASN62 |
| A | SO4402 |
| A | SO3502 |
| A | HOH866 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CS A 611 |
| Chain | Residue |
| A | ASN3 |
| A | ILE4 |
| A | THR30 |
| A | HOH643 |
| A | HOH875 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; cysteine thioarsenate intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01282","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11709171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15295115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7577935","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for activity. Lowers pKa of the active site Cys","evidences":[{"source":"PubMed","id":"8969183","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Important for activity. Involved in arsenate binding and transition-state stabilization","evidences":[{"source":"PubMed","id":"11709171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14592722","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15295115","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
