1I6M
1.7 HIGH RESOLUTION EXPERIMENTAL PHASES FOR TRYPTOPHANYL-TRNA SYNTHETASE COMPLEXED WITH TRYPTOPHANYL-5'AMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 360 |
| Chain | Residue |
| A | ARG160 |
| A | LYS163 |
| A | HOH443 |
| A | HOH550 |
| A | HOH592 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 361 |
| Chain | Residue |
| A | THR222 |
| A | TYR265 |
| A | LYS269 |
| A | HOH690 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 362 |
| Chain | Residue |
| A | ARG316 |
| A | HOH673 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 363 |
| Chain | Residue |
| A | GLY264 |
| A | TYR265 |
| A | GLY266 |
| A | HOH529 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 364 |
| Chain | Residue |
| A | ARG182 |
| A | MET184 |
| A | THR190 |
| A | LYS232 |
| A | HOH498 |
| A | HOH518 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 365 |
| Chain | Residue |
| A | LYS178 |
| A | GLY180 |
| A | ALA181 |
| A | ARG182 |
| A | TYR230 |
| A | ASN243 |
| A | HOH506 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 366 |
| Chain | Residue |
| A | ARG60 |
| A | TYR287 |
| A | MET291 |
| A | HOH539 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NH4 A 400 |
| Chain | Residue |
| A | GLN30 |
| A | TYR33 |
| A | GLN74 |
| A | GOL370 |
| A | HOH570 |
| site_id | AC9 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE TYM A 350 |
| Chain | Residue |
| A | PHE5 |
| A | SER6 |
| A | GLY7 |
| A | ILE8 |
| A | GLN9 |
| A | GLY17 |
| A | ASN18 |
| A | GLY21 |
| A | ALA22 |
| A | VAL40 |
| A | HIS43 |
| A | TYR125 |
| A | MET129 |
| A | ASP132 |
| A | ILE133 |
| A | VAL141 |
| A | VAL143 |
| A | GLY144 |
| A | ASP146 |
| A | GLN147 |
| A | GLY180 |
| A | ALA181 |
| A | ARG182 |
| A | ILE183 |
| A | LYS192 |
| A | MET193 |
| A | LYS195 |
| A | HOH402 |
| A | HOH408 |
| A | HOH561 |
| A | HOH593 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 370 |
| Chain | Residue |
| A | ASN34 |
| A | CYS35 |
| A | TYR36 |
| A | GLN74 |
| A | THR76 |
| A | LYS215 |
| A | LYS306 |
| A | NH4400 |
| A | HOH477 |
| A | HOH570 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 371 |
| Chain | Residue |
| A | GLY12 |
| A | VAL13 |
| A | ILE14 |
| A | ARG60 |
| A | THR205 |
| A | LEU207 |
| A | HOH706 |
| A | HOH714 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 372 |
| Chain | Residue |
| A | LYS211 |
| A | LYS215 |
| A | LYS306 |
| A | ARG309 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 373 |
| Chain | Residue |
| A | LYS192 |
| A | SER194 |
| A | LYS195 |
| A | SER196 |
| A | HOH593 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 10 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..SGvITIGNY |
| Chain | Residue | Details |
| A | PRO10-TYR19 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"'HIGH' region","evidences":[{"source":"HAMAP-Rule","id":"MF_00140","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Motif: {"description":"'KMSKS' region","evidences":[{"source":"HAMAP-Rule","id":"MF_00140","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26555258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DK4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| A | LYS192 | |
| A | LYS195 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 481 |
| Chain | Residue | Details |
| A | LYS111 | electrostatic stabiliser |
| A | LYS192 | electrostatic stabiliser |
| A | LYS195 | electrostatic stabiliser |
