1I3E
HUMAN AZIDO-MET HEMOGLOBIN BART'S (GAMMA4)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005344 | molecular_function | oxygen carrier activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005833 | cellular_component | hemoglobin complex |
| A | 0015670 | biological_process | carbon dioxide transport |
| A | 0015671 | biological_process | oxygen transport |
| A | 0019825 | molecular_function | oxygen binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0031721 | molecular_function | hemoglobin alpha binding |
| A | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048821 | biological_process | erythrocyte development |
| B | 0005344 | molecular_function | oxygen carrier activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005833 | cellular_component | hemoglobin complex |
| B | 0015670 | biological_process | carbon dioxide transport |
| B | 0015671 | biological_process | oxygen transport |
| B | 0019825 | molecular_function | oxygen binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0031721 | molecular_function | hemoglobin alpha binding |
| B | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048821 | biological_process | erythrocyte development |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE AZI A 148 |
| Chain | Residue |
| A | LEU28 |
| A | HIS63 |
| A | VAL67 |
| A | LEU106 |
| A | HEM147 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE AZI B 148 |
| Chain | Residue |
| B | HEM147 |
| B | LEU28 |
| B | HIS63 |
| B | VAL67 |
| B | LEU106 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE HEM A 147 |
| Chain | Residue |
| A | PHE41 |
| A | PHE42 |
| A | HIS63 |
| A | SER70 |
| A | HIS92 |
| A | LEU96 |
| A | VAL98 |
| A | ASN102 |
| A | PHE103 |
| A | LEU106 |
| A | LEU141 |
| A | AZI148 |
| A | HOH250 |
| A | HOH282 |
| A | HOH369 |
| A | HOH374 |
| B | SER50 |
| B | SER52 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE HEM B 147 |
| Chain | Residue |
| A | SER52 |
| B | PHE41 |
| B | PHE42 |
| B | PHE45 |
| B | HIS63 |
| B | VAL67 |
| B | SER70 |
| B | LEU91 |
| B | HIS92 |
| B | LEU96 |
| B | VAL98 |
| B | ASN102 |
| B | LEU106 |
| B | LEU141 |
| B | AZI148 |
| B | HOH293 |
| B | HOH410 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 288 |
| Details | Domain: {"description":"Globin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"distal binding residue","evidences":[{"source":"UniProtKB","id":"P80044","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"proximal binding residue","evidences":[{"source":"PubMed","id":"11514664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1I3D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1I3E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylglycine; in form Hb F1","evidences":[{"source":"PubMed","id":"5554303","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P68871","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P68871","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P68871","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
