1I2D

CRYSTAL STRUCTURE OF ATP SULFURYLASE FROM PENICILLIUM CHRYSOGENUM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000103	biological_process	sulfate assimilation
A	0004020	molecular_function	adenylylsulfate kinase activity
A	0004781	molecular_function	sulfate adenylyltransferase (ATP) activity
A	0005524	molecular_function	ATP binding
B	0000103	biological_process	sulfate assimilation
B	0004020	molecular_function	adenylylsulfate kinase activity
B	0004781	molecular_function	sulfate adenylyltransferase (ATP) activity
B	0005524	molecular_function	ATP binding
C	0000103	biological_process	sulfate assimilation
C	0004020	molecular_function	adenylylsulfate kinase activity
C	0004781	molecular_function	sulfate adenylyltransferase (ATP) activity
C	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADX A 574

Chain	Residue
A	PHE196
A	ALA295
A	MET332
A	VAL333
A	HOH616
A	HOH735
A	GLN197
A	THR198
A	ARG199
A	ASN200
A	HIS206
A	GLY291
A	ARG292
A	HIS294

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADX A 575

Chain	Residue
A	MET405
A	ASP434
A	ARG437
A	PHE446
A	ARG451
A	ASN454
A	PRO476
A	ILE477
A	ALA478
A	PRO479
A	LYS527
A	GLY528
A	PHE529
A	THR530
A	HOH634

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADX B 576

Chain	Residue
B	PHE196
B	GLN197
B	THR198
B	ARG199
B	ASN200
B	HIS206
B	LEU209
B	GLY291
B	ARG292
B	HIS294
B	ALA295
B	MET332
B	VAL333
B	HOH592
B	HOH641

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADX B 577

Chain	Residue
B	MET405
B	ASP434
B	ARG437
B	PHE446
B	ARG451
B	ASN454
B	PRO476
B	ILE477
B	ALA478
B	PRO479
B	ILE517
B	LYS527
B	GLY528
B	PHE529
B	THR530
B	HOH578

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADX C 578

Chain	Residue
C	PHE196
C	GLN197
C	THR198
C	ARG199
C	ASN200
C	HIS206
C	GLY291
C	ARG292
C	HIS294
C	ALA295
C	GLN331
C	MET332
C	VAL333

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADX C 579

Chain	Residue
C	MET405
C	GLY433
C	ASP434
C	ARG437
C	PHE446
C	ARG451
C	ASN454
C	PRO476
C	ILE477
C	ALA478
C	PRO479
C	LYS527
C	GLY528
C	PHE529
C	THR530

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_03106

Chain	Residue	Details
A	THR198
A	ARG199
A	ASN200
B	THR198
B	ARG199
B	ASN200
C	THR198
C	ARG199
C	ASN200

---

site_id	SWS_FT_FI2
Number of Residues	15
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03106, ECO:0000269|PubMed:11389593

Chain	Residue	Details
A	GLN197
B	VAL333
C	GLN197
C	ARG199
C	GLY291
C	ALA295
C	VAL333
A	ARG199
A	GLY291
A	ALA295
A	VAL333
B	GLN197
B	ARG199
B	GLY291
B	ALA295

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03106, ECO:0000269|PubMed:12426581

Chain	Residue	Details
A	ASP434
C	ARG451
C	ILE477
C	ARG515
A	ARG451
A	ILE477
A	ARG515
B	ASP434
B	ARG451
B	ILE477
B	ARG515
C	ASP434

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_03106

Chain	Residue	Details
A	HIS203
B	HIS203
C	HIS203

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_03106, ECO:0000305|PubMed:11389593

Chain	Residue	Details
A	HIS206
B	HIS206
C	HIS206

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	SITE: Induces change in substrate recognition on ATP binding => ECO:0000255|HAMAP-Rule:MF_03106

Chain	Residue	Details
A	PHE330
B	PHE330
C	PHE330

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1j70

Chain	Residue	Details
A	ARG199
A	HIS206
A	HIS203

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1j70

Chain	Residue	Details
B	ARG199
B	HIS206
B	HIS203

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1j70

Chain	Residue	Details
C	ARG199
C	HIS206
C	HIS203

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1j70

Chain	Residue	Details
A	ARG292

---

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1j70

Chain	Residue	Details
B	ARG292

---

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1j70

Chain	Residue	Details
C	ARG292

---