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1I22

MUTANT HUMAN LYSOZYME (A83K/Q86D/A92D)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003796molecular_functionlysozyme activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006954biological_processinflammatory response
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0019730biological_processantimicrobial humoral response
A0031640biological_processkilling of cells of another organism
A0035578cellular_componentazurophil granule lumen
A0035580cellular_componentspecific granule lumen
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0050829biological_processdefense response to Gram-negative bacterium
A0050830biological_processdefense response to Gram-positive bacterium
A0070062cellular_componentextracellular exosome
A1904724cellular_componenttertiary granule lumen
B0003796molecular_functionlysozyme activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006954biological_processinflammatory response
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0019730biological_processantimicrobial humoral response
B0031640biological_processkilling of cells of another organism
B0035578cellular_componentazurophil granule lumen
B0035580cellular_componentspecific granule lumen
B0042742biological_processdefense response to bacterium
B0042802molecular_functionidentical protein binding
B0050829biological_processdefense response to Gram-negative bacterium
B0050830biological_processdefense response to Gram-positive bacterium
B0070062cellular_componentextracellular exosome
B1904724cellular_componenttertiary granule lumen
C0003796molecular_functionlysozyme activity
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006954biological_processinflammatory response
C0016798molecular_functionhydrolase activity, acting on glycosyl bonds
C0019730biological_processantimicrobial humoral response
C0031640biological_processkilling of cells of another organism
C0035578cellular_componentazurophil granule lumen
C0035580cellular_componentspecific granule lumen
C0042742biological_processdefense response to bacterium
C0042802molecular_functionidentical protein binding
C0050829biological_processdefense response to Gram-negative bacterium
C0050830biological_processdefense response to Gram-positive bacterium
C0070062cellular_componentextracellular exosome
C1904724cellular_componenttertiary granule lumen
D0003796molecular_functionlysozyme activity
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006954biological_processinflammatory response
D0016798molecular_functionhydrolase activity, acting on glycosyl bonds
D0019730biological_processantimicrobial humoral response
D0031640biological_processkilling of cells of another organism
D0035578cellular_componentazurophil granule lumen
D0035580cellular_componentspecific granule lumen
D0042742biological_processdefense response to bacterium
D0042802molecular_functionidentical protein binding
D0050829biological_processdefense response to Gram-negative bacterium
D0050830biological_processdefense response to Gram-positive bacterium
D0070062cellular_componentextracellular exosome
D1904724cellular_componenttertiary granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CA B 197
ChainResidue
BLYS83
BASP86
BASN88
BASP91
BASP92
BHOH257
BHOH518

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 198
ChainResidue
AASN88
AASP91
AASP92
AHOH420
ALYS83
AASP86

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 199
ChainResidue
CLYS83
CASP86
CASN88
CASP91
CASP92
CHOH309

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 200
ChainResidue
DLYS83
DASP86
DASN88
DASP91
DASP92
DHOH201

Functional Information from PROSITE/UniProt
site_idPS00128
Number of Residues19
DetailsGLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. ChlsCskLlddNIaddvaC
ChainResidueDetails
ACYS77-CYS95

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE:
ChainResidueDetails
AGLU35
AASP53
BGLU35
BASP53
CGLU35
CASP53
DGLU35
DASP53

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 132l
ChainResidueDetails
AGLU35
AASP53

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 132l
ChainResidueDetails
BGLU35
BASP53

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 132l
ChainResidueDetails
CGLU35
CASP53

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 132l
ChainResidueDetails
DGLU35
DASP53

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PDB entries from 2024-07-17

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