1I10
HUMAN MUSCLE L-LACTATE DEHYDROGENASE M CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004457 | molecular_function | lactate dehydrogenase activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019661 | biological_process | glucose catabolic process to lactate via pyruvate |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0035686 | cellular_component | sperm fibrous sheath |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042867 | biological_process | pyruvate catabolic process |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1990204 | cellular_component | oxidoreductase complex |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004457 | molecular_function | lactate dehydrogenase activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019661 | biological_process | glucose catabolic process to lactate via pyruvate |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0035686 | cellular_component | sperm fibrous sheath |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042867 | biological_process | pyruvate catabolic process |
| B | 0045296 | molecular_function | cadherin binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1990204 | cellular_component | oxidoreductase complex |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004457 | molecular_function | lactate dehydrogenase activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005829 | cellular_component | cytosol |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019661 | biological_process | glucose catabolic process to lactate via pyruvate |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0035686 | cellular_component | sperm fibrous sheath |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042867 | biological_process | pyruvate catabolic process |
| C | 0045296 | molecular_function | cadherin binding |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 1990204 | cellular_component | oxidoreductase complex |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004457 | molecular_function | lactate dehydrogenase activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005829 | cellular_component | cytosol |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019661 | biological_process | glucose catabolic process to lactate via pyruvate |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0035686 | cellular_component | sperm fibrous sheath |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0042867 | biological_process | pyruvate catabolic process |
| D | 0045296 | molecular_function | cadherin binding |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 1990204 | cellular_component | oxidoreductase complex |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004457 | molecular_function | lactate dehydrogenase activity |
| E | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005829 | cellular_component | cytosol |
| E | 0006089 | biological_process | lactate metabolic process |
| E | 0006096 | biological_process | glycolytic process |
| E | 0016020 | cellular_component | membrane |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| E | 0019661 | biological_process | glucose catabolic process to lactate via pyruvate |
| E | 0019752 | biological_process | carboxylic acid metabolic process |
| E | 0035686 | cellular_component | sperm fibrous sheath |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0042867 | biological_process | pyruvate catabolic process |
| E | 0045296 | molecular_function | cadherin binding |
| E | 0070062 | cellular_component | extracellular exosome |
| E | 1990204 | cellular_component | oxidoreductase complex |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004457 | molecular_function | lactate dehydrogenase activity |
| F | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005829 | cellular_component | cytosol |
| F | 0006089 | biological_process | lactate metabolic process |
| F | 0006096 | biological_process | glycolytic process |
| F | 0016020 | cellular_component | membrane |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| F | 0019661 | biological_process | glucose catabolic process to lactate via pyruvate |
| F | 0019752 | biological_process | carboxylic acid metabolic process |
| F | 0035686 | cellular_component | sperm fibrous sheath |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0042867 | biological_process | pyruvate catabolic process |
| F | 0045296 | molecular_function | cadherin binding |
| F | 0070062 | cellular_component | extracellular exosome |
| F | 1990204 | cellular_component | oxidoreductase complex |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004457 | molecular_function | lactate dehydrogenase activity |
| G | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005829 | cellular_component | cytosol |
| G | 0006089 | biological_process | lactate metabolic process |
| G | 0006096 | biological_process | glycolytic process |
| G | 0016020 | cellular_component | membrane |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| G | 0019661 | biological_process | glucose catabolic process to lactate via pyruvate |
| G | 0019752 | biological_process | carboxylic acid metabolic process |
| G | 0035686 | cellular_component | sperm fibrous sheath |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0042867 | biological_process | pyruvate catabolic process |
| G | 0045296 | molecular_function | cadherin binding |
| G | 0070062 | cellular_component | extracellular exosome |
| G | 1990204 | cellular_component | oxidoreductase complex |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004457 | molecular_function | lactate dehydrogenase activity |
| H | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005634 | cellular_component | nucleus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005829 | cellular_component | cytosol |
| H | 0006089 | biological_process | lactate metabolic process |
| H | 0006096 | biological_process | glycolytic process |
| H | 0016020 | cellular_component | membrane |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| H | 0019661 | biological_process | glucose catabolic process to lactate via pyruvate |
| H | 0019752 | biological_process | carboxylic acid metabolic process |
| H | 0035686 | cellular_component | sperm fibrous sheath |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0042867 | biological_process | pyruvate catabolic process |
| H | 0045296 | molecular_function | cadherin binding |
| H | 0070062 | cellular_component | extracellular exosome |
| H | 1990204 | cellular_component | oxidoreductase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 803 |
| Chain | Residue |
| A | ARG170 |
| A | HIS185 |
| A | HOH898 |
| A | HOH900 |
| A | HOH907 |
| C | LEU182 |
| C | HIS185 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 806 |
| Chain | Residue |
| B | HOH839 |
| B | HOH848 |
| B | HOH891 |
| D | HIS185 |
| B | ARG170 |
| B | HIS185 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT C 809 |
| Chain | Residue |
| A | HIS185 |
| A | HOH895 |
| A | HOH928 |
| C | ARG170 |
| C | HIS185 |
| C | HOH854 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT D 812 |
| Chain | Residue |
| B | HIS185 |
| B | HOH816 |
| D | ARG170 |
| D | HIS185 |
| D | HOH825 |
| D | HOH855 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT E 815 |
| Chain | Residue |
| E | ARG170 |
| E | HIS185 |
| E | TRP187 |
| G | HIS185 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT F 818 |
| Chain | Residue |
| F | ARG170 |
| F | HIS185 |
| F | HOH822 |
| F | HOH838 |
| H | HIS185 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT G 821 |
| Chain | Residue |
| E | LEU182 |
| E | HIS185 |
| G | ARG170 |
| G | HIS185 |
| G | TRP187 |
| G | HOH822 |
| G | HOH834 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT H 824 |
| Chain | Residue |
| F | HIS185 |
| H | ARG170 |
| H | HIS185 |
| site_id | AC9 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAI A 801 |
| Chain | Residue |
| A | GLY28 |
| A | ALA29 |
| A | VAL30 |
| A | ASP51 |
| A | VAL52 |
| A | ILE53 |
| A | LYS56 |
| A | THR94 |
| A | ALA95 |
| A | GLY96 |
| A | ALA97 |
| A | ARG98 |
| A | ILE119 |
| A | VAL135 |
| A | ASN137 |
| A | SER160 |
| A | LEU164 |
| A | HIS192 |
| A | THR247 |
| A | ILE251 |
| A | OXM802 |
| A | HOH804 |
| A | HOH807 |
| A | HOH814 |
| A | HOH826 |
| A | HOH851 |
| A | HOH864 |
| A | HOH877 |
| A | HOH885 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE OXM A 802 |
| Chain | Residue |
| A | GLN99 |
| A | ARG105 |
| A | ASN137 |
| A | LEU164 |
| A | ARG168 |
| A | HIS192 |
| A | ALA237 |
| A | THR247 |
| A | NAI801 |
| site_id | BC2 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAI B 804 |
| Chain | Residue |
| B | SER160 |
| B | LEU164 |
| B | HIS192 |
| B | THR247 |
| B | ILE251 |
| B | OXM805 |
| B | HOH812 |
| B | HOH814 |
| B | HOH831 |
| B | HOH855 |
| B | HOH907 |
| B | HOH916 |
| B | HOH929 |
| F | ASN107 |
| B | GLY28 |
| B | ALA29 |
| B | VAL30 |
| B | ASP51 |
| B | VAL52 |
| B | ILE53 |
| B | LYS56 |
| B | THR94 |
| B | ALA95 |
| B | GLY96 |
| B | ALA97 |
| B | ARG98 |
| B | ILE115 |
| B | ILE119 |
| B | VAL135 |
| B | SER136 |
| B | ASN137 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OXM B 805 |
| Chain | Residue |
| B | GLN99 |
| B | ARG105 |
| B | ASN137 |
| B | ARG168 |
| B | HIS192 |
| B | ALA237 |
| B | THR247 |
| B | NAI804 |
| site_id | BC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAI C 807 |
| Chain | Residue |
| C | GLY28 |
| C | ALA29 |
| C | VAL30 |
| C | ASP51 |
| C | VAL52 |
| C | ILE53 |
| C | LYS56 |
| C | THR94 |
| C | ALA95 |
| C | GLY96 |
| C | ALA97 |
| C | ARG98 |
| C | ILE119 |
| C | VAL135 |
| C | ASN137 |
| C | SER160 |
| C | LEU164 |
| C | HIS192 |
| C | THR247 |
| C | ILE251 |
| C | OXM808 |
| C | HOH836 |
| C | HOH855 |
| C | HOH856 |
| C | HOH857 |
| C | HOH861 |
| H | ASN107 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OXM C 808 |
| Chain | Residue |
| C | GLN99 |
| C | ARG105 |
| C | ASN137 |
| C | ARG168 |
| C | HIS192 |
| C | ALA237 |
| C | THR247 |
| C | NAI807 |
| site_id | BC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NAI D 810 |
| Chain | Residue |
| D | GLY26 |
| D | GLY28 |
| D | ALA29 |
| D | VAL30 |
| D | ASP51 |
| D | VAL52 |
| D | ILE53 |
| D | THR94 |
| D | ALA95 |
| D | GLY96 |
| D | ARG98 |
| D | ILE115 |
| D | ILE119 |
| D | VAL135 |
| D | ASN137 |
| D | SER160 |
| D | HIS192 |
| D | OXM811 |
| D | HOH858 |
| D | HOH889 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE OXM D 811 |
| Chain | Residue |
| D | ASN137 |
| D | ARG168 |
| D | HIS192 |
| D | ALA237 |
| D | THR247 |
| D | NAI810 |
| site_id | BC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAI E 813 |
| Chain | Residue |
| A | GLN110 |
| A | HOH937 |
| E | GLY28 |
| E | ALA29 |
| E | VAL30 |
| E | ASP51 |
| E | VAL52 |
| E | THR94 |
| E | ALA95 |
| E | GLY96 |
| E | VAL135 |
| E | ASN137 |
| E | SER160 |
| E | LEU164 |
| E | HIS192 |
| E | THR247 |
| E | ILE251 |
| E | OXM814 |
| E | HOH839 |
| E | HOH847 |
| E | HOH851 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE OXM E 814 |
| Chain | Residue |
| E | ASN137 |
| E | LEU164 |
| E | ARG168 |
| E | HIS192 |
| E | ALA237 |
| E | THR247 |
| E | NAI813 |
| site_id | CC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAI F 816 |
| Chain | Residue |
| F | GLY28 |
| F | ALA29 |
| F | VAL30 |
| F | ASP51 |
| F | VAL52 |
| F | ILE53 |
| F | THR94 |
| F | ALA95 |
| F | GLY96 |
| F | ALA97 |
| F | ARG98 |
| F | ILE115 |
| F | VAL135 |
| F | ASN137 |
| F | SER160 |
| F | LEU164 |
| F | HIS192 |
| F | THR247 |
| F | ILE251 |
| F | OXM817 |
| F | HOH832 |
| F | HOH837 |
| F | HOH845 |
| F | HOH851 |
| F | HOH861 |
| F | HOH862 |
| site_id | CC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OXM F 817 |
| Chain | Residue |
| F | GLN99 |
| F | ARG105 |
| F | ASN137 |
| F | ARG168 |
| F | HIS192 |
| F | ALA237 |
| F | THR247 |
| F | NAI816 |
| site_id | CC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NAI G 819 |
| Chain | Residue |
| D | GLN330 |
| G | GLY28 |
| G | ALA29 |
| G | VAL30 |
| G | ASP51 |
| G | VAL52 |
| G | ILE53 |
| G | THR94 |
| G | ALA95 |
| G | GLY96 |
| G | VAL135 |
| G | SER136 |
| G | ASN137 |
| G | LEU164 |
| G | HIS192 |
| G | THR247 |
| G | ILE251 |
| G | OXM820 |
| G | HOH825 |
| G | HOH831 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE OXM G 820 |
| Chain | Residue |
| G | ASN137 |
| G | LEU164 |
| G | ARG168 |
| G | HIS192 |
| G | ALA237 |
| G | NAI819 |
| site_id | CC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAI H 822 |
| Chain | Residue |
| H | GLY28 |
| H | ALA29 |
| H | VAL30 |
| H | ASP51 |
| H | ILE53 |
| H | THR94 |
| H | ALA95 |
| H | GLY96 |
| H | ALA97 |
| H | ARG98 |
| H | ILE115 |
| H | VAL135 |
| H | ASN137 |
| H | SER160 |
| H | LEU164 |
| H | HIS192 |
| H | THR247 |
| H | ILE251 |
| H | OXM823 |
| H | HOH830 |
| H | HOH847 |
| H | HOH864 |
| H | HOH873 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OXM H 823 |
| Chain | Residue |
| H | GLN99 |
| H | ARG105 |
| H | ASN137 |
| H | ARG168 |
| H | HIS192 |
| H | ALA237 |
| H | THR247 |
| H | NAI822 |
Functional Information from PROSITE/UniProt
| site_id | PS00064 |
| Number of Residues | 7 |
| Details | L_LDH L-lactate dehydrogenase active site. LGEHGDS |
| Chain | Residue | Details |
| A | LEU189-SER195 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 232 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11276087","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 31 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 24 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P06151","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 16 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P04642","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 16 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | HIS192 | |
| A | ASP165 |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| B | HIS192 | |
| B | ASP165 | |
| B | ARG168 |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| C | HIS192 | |
| C | ASP165 | |
| C | ARG168 |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| D | HIS192 | |
| D | ASP165 | |
| D | ARG168 |
| site_id | CSA13 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| E | HIS192 | |
| E | ASP165 | |
| E | ARG168 |
| site_id | CSA14 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| F | HIS192 | |
| F | ASP165 | |
| F | ARG168 |
| site_id | CSA15 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| G | HIS192 | |
| G | ASP165 | |
| G | ARG168 |
| site_id | CSA16 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| H | HIS192 | |
| H | ASP165 | |
| H | ARG168 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| B | HIS192 | |
| B | ASP165 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| C | HIS192 | |
| C | ASP165 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| D | HIS192 | |
| D | ASP165 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| E | HIS192 | |
| E | ASP165 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| F | HIS192 | |
| F | ASP165 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| G | HIS192 | |
| G | ASP165 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| H | HIS192 | |
| H | ASP165 |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | HIS192 | |
| A | ASP165 | |
| A | ARG168 |
