1HWT

STRUCTURE OF A HAP1/DNA COMPLEX REVEALS DRAMATICALLY ASYMMETRIC DNA BINDING BY A HOMODIMERIC PROTEIN

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008270	molecular_function	zinc ion binding
D	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
G	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0006355	biological_process	regulation of DNA-templated transcription
G	0008270	molecular_function	zinc ion binding
H	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0006355	biological_process	regulation of DNA-templated transcription
H	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 136

Chain	Residue
C	CYS64
C	CYS67
C	CYS74
C	CYS81
C	ZN137

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 137

Chain	Residue
C	CYS64
C	CYS81
C	CYS84
C	CYS93
C	ZN136

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 136

Chain	Residue
D	CYS64
D	CYS67
D	CYS74
D	CYS81
D	ZN137

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 137

Chain	Residue
D	CYS64
D	CYS81
D	CYS84
D	CYS93
D	ZN136

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN G 136

Chain	Residue
G	CYS64
G	CYS67
G	CYS74
G	CYS81
G	ZN137

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN G 137

Chain	Residue
G	CYS64
G	CYS81
G	CYS84
G	CYS93
G	ZN136

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 136

Chain	Residue
H	CYS64
H	CYS67
H	CYS74
H	CYS81
H	ZN137

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 137

Chain	Residue
H	CYS64
H	CYS81
H	CYS84
H	CYS93
H	ZN136

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 138

Chain	Residue
D	HIS80
D	HIS91
H	HIS80
H	HIS91

---

site_id	ZN1
Number of Residues	6
Details

Chain	Residue
C	CYS64
C	CYS67
C	CYS74
C	CYS81
C	CYS84
C	CYS93

---

site_id	ZN2
Number of Residues	6
Details

Chain	Residue
D	CYS81
D	CYS84
D	CYS93
D	CYS64
D	CYS67
D	CYS74

---

site_id	ZN3
Number of Residues	6
Details

Chain	Residue
G	CYS64
G	CYS67
G	CYS74
G	CYS81
G	CYS84
G	CYS93

---

site_id	ZN4
Number of Residues	6
Details

Chain	Residue
H	CYS64
H	CYS67
H	CYS74
H	CYS81
H	CYS84
H	CYS93

---

site_id	ZN5
Number of Residues	4
Details

Chain	Residue
H	HIS80
H	HIS91
D	HIS91
D	HIS80

---

Functional Information from PROSITE/UniProt

site_id	PS00463
Number of Residues	31
Details	ZN2_CY6_FUNGAL_1 Zn(2)-C6 fungal-type DNA-binding domain signature. SCtiCRkrKvkCdklrph......CqqCtktgvahlC

Chain	Residue	Details
C	SER63-CYS93

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	DNA_BIND: Zn(2)-C6 fungal-type => ECO:0000255|PROSITE-ProRule:PRU00227

Chain	Residue	Details
C	CYS64-CYS93
D	CYS64-CYS93
G	CYS64-CYS93
H	CYS64-CYS93

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
C	CYS64
D	CYS81
D	CYS84
D	CYS93
G	CYS64
G	CYS67
G	CYS74
G	CYS81
G	CYS84
G	CYS93
H	CYS64
C	CYS67
H	CYS67
H	CYS74
H	CYS81
H	CYS84
H	CYS93
C	CYS74
C	CYS81
C	CYS84
C	CYS93
D	CYS64
D	CYS67
D	CYS74

---