1HVD

STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OF ANNEXIN V MUTANTS. MUTAGENESIS OF HUMAN ANNEXIN V, AN IN VITRO VOLTAGE-GATED CALCIUM CHANNEL, PROVIDES INFORMATION ABOUT THE STRUCTURAL FEATURES OF THE ION PATHWAY, THE VOLTAGE SENSOR AND THE ION SELECTIVITY FILTER

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001786	molecular_function	phosphatidylserine binding
A	0004859	molecular_function	phospholipase inhibitor activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005544	molecular_function	calcium-dependent phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0007165	biological_process	signal transduction
A	0007596	biological_process	blood coagulation
A	0009897	cellular_component	external side of plasma membrane
A	0012506	cellular_component	vesicle membrane
A	0016020	cellular_component	membrane
A	0042383	cellular_component	sarcolemma
A	0043066	biological_process	negative regulation of apoptotic process
A	0050819	biological_process	negative regulation of coagulation
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0070062	cellular_component	extracellular exosome
A	0072563	cellular_component	endothelial microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 600

Chain	Residue
A	LEU100
A	LYS101
A	GLY102
A	GLY104
A	THR105
A	ASP144

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 601

Chain	Residue
A	ASP303
A	HOH483
A	MET259
A	GLY261
A	GLY263

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 602

Chain	Residue
A	MET28
A	GLY30
A	GLY32
A	GLU72
A	HOH417

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 603

Chain	Residue
A	THR33
A	GLU35
A	HOH485

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Functional Information from PROSITE/UniProt

site_id	PS00223
Number of Residues	53
Details	ANNEXIN_1 Annexin repeat signature. GTdeesiltlLtsRsnaQrqEisaaFktlfgrdLlddLkseltGkfeklIvaL

Chain	Residue	Details
A	GLY32-LEU84
A	GLY104-LEU156
A	GLY188-VAL240
A	GLY263-LEU315

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	GLN3

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P48036

Chain	Residue	Details
A	ILE38

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	SER71
A	PHE77
A	LEU80
A	HIS98

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:16916647

Chain	Residue	Details
A	GLY102

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P48036

Chain	Residue	Details
A	ASN291

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	GLY30

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