1HV5
CRYSTAL STRUCTURE OF THE STROMELYSIN-3 (MMP-11) CATALYTIC DOMAIN COMPLEXED WITH A PHOSPHINIC INHIBITOR
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
C | 0004222 | molecular_function | metalloendopeptidase activity |
C | 0006508 | biological_process | proteolysis |
C | 0008237 | molecular_function | metallopeptidase activity |
C | 0008270 | molecular_function | zinc ion binding |
C | 0031012 | cellular_component | extracellular matrix |
D | 0004222 | molecular_function | metalloendopeptidase activity |
D | 0006508 | biological_process | proteolysis |
D | 0008237 | molecular_function | metallopeptidase activity |
D | 0008270 | molecular_function | zinc ion binding |
D | 0031012 | cellular_component | extracellular matrix |
E | 0004222 | molecular_function | metalloendopeptidase activity |
E | 0006508 | biological_process | proteolysis |
E | 0008237 | molecular_function | metallopeptidase activity |
E | 0008270 | molecular_function | zinc ion binding |
E | 0031012 | cellular_component | extracellular matrix |
F | 0004222 | molecular_function | metalloendopeptidase activity |
F | 0006508 | biological_process | proteolysis |
F | 0008237 | molecular_function | metallopeptidase activity |
F | 0008270 | molecular_function | zinc ion binding |
F | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 5501 |
Chain | Residue |
A | HIS168 |
A | ASP170 |
A | HIS183 |
A | HIS196 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 5502 |
Chain | Residue |
A | HIS219 |
A | HIS223 |
A | HIS229 |
A | RXP6001 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 5503 |
Chain | Residue |
A | GLY176 |
A | GLY178 |
A | ILE180 |
A | ASP198 |
A | GLU201 |
A | ASP175 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 5504 |
Chain | Residue |
B | HIS168 |
B | ASP170 |
B | HIS183 |
B | HIS196 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN B 5505 |
Chain | Residue |
B | HIS219 |
B | HIS223 |
B | HIS229 |
B | RXP6002 |
B | HOH6300 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 5506 |
Chain | Residue |
B | ASP175 |
B | GLY176 |
B | GLY178 |
B | ILE180 |
B | ASP198 |
B | GLU201 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 5507 |
Chain | Residue |
C | HIS168 |
C | ASP170 |
C | HIS183 |
C | HIS196 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 5508 |
Chain | Residue |
C | HIS219 |
C | HIS223 |
C | HIS229 |
C | RXP6003 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA C 5509 |
Chain | Residue |
C | ASP175 |
C | GLY176 |
C | GLY178 |
C | ILE180 |
C | ASP198 |
C | GLU201 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN D 5510 |
Chain | Residue |
D | HIS168 |
D | ASP170 |
D | HIS183 |
D | HIS196 |
D | HOH1632 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 5511 |
Chain | Residue |
D | HIS219 |
D | HIS223 |
D | HIS229 |
D | RXP6004 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA D 5512 |
Chain | Residue |
D | ASP175 |
D | GLY176 |
D | GLY178 |
D | ILE180 |
D | ASP198 |
D | GLU201 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN E 5513 |
Chain | Residue |
E | HIS168 |
E | ASP170 |
E | HIS183 |
E | HIS196 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN E 5514 |
Chain | Residue |
E | HIS219 |
E | HIS223 |
E | HIS229 |
E | RXP6005 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA E 5515 |
Chain | Residue |
E | ASP175 |
E | GLY176 |
E | GLY178 |
E | ILE180 |
E | ASP198 |
E | GLU201 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN F 5516 |
Chain | Residue |
F | HIS168 |
F | ASP170 |
F | HIS183 |
F | HIS196 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN F 5517 |
Chain | Residue |
F | HIS219 |
F | HIS223 |
F | HIS229 |
F | RXP6006 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA F 5518 |
Chain | Residue |
F | ASP175 |
F | GLY176 |
F | GLY178 |
F | ILE180 |
F | ASP198 |
F | GLU201 |
site_id | CC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE CPS A 5001 |
Chain | Residue |
A | HIS223 |
A | GLN228 |
A | HIS229 |
A | RXP6001 |
A | HOH6033 |
A | HOH6081 |
A | HOH6149 |
A | HOH6374 |
site_id | CC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CPS B 5002 |
Chain | Residue |
B | HOH6208 |
B | HOH6300 |
B | HIS223 |
B | GLN228 |
B | HIS229 |
B | RXP6002 |
B | HOH6095 |
site_id | CC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CPS C 5003 |
Chain | Residue |
B | TRP167 |
C | GLN228 |
C | HIS229 |
C | RXP6003 |
C | HOH6155 |
C | HOH6356 |
site_id | CC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CPS D 5004 |
Chain | Residue |
D | HIS223 |
D | GLN228 |
D | HIS229 |
D | HOH757 |
D | HOH1050 |
D | HOH1126 |
site_id | CC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CPS E 5005 |
Chain | Residue |
E | HIS223 |
E | GLN228 |
E | HIS229 |
E | RXP6005 |
E | HOH6108 |
E | HOH6137 |
site_id | CC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE CPS A 5006 |
Chain | Residue |
A | LEU147 |
A | PHE186 |
A | ARG191 |
A | GLU192 |
A | VAL224 |
A | HOH6186 |
A | HOH6217 |
A | HOH6242 |
site_id | CC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE CPS B 5007 |
Chain | Residue |
B | LYS111 |
B | ASP158 |
B | PHE186 |
B | GLU192 |
B | VAL224 |
B | GLY226 |
B | TYR261 |
B | HOH6134 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CPS C 5008 |
Chain | Residue |
C | PHE186 |
C | ARG191 |
C | GLU192 |
C | VAL224 |
C | TYR261 |
C | HOH6151 |
site_id | CC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CPS D 5009 |
Chain | Residue |
D | PHE186 |
D | ARG191 |
D | TYR261 |
D | HOH689 |
D | HOH839 |
site_id | DC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE CPS E 5010 |
Chain | Residue |
E | ASP158 |
E | GLU192 |
E | GLY193 |
E | VAL224 |
E | LEU225 |
E | GLY226 |
E | TYR261 |
E | HOH6059 |
E | HOH6161 |
E | HOH6320 |
site_id | DC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE CPS F 5011 |
Chain | Residue |
F | LEU114 |
F | ASP158 |
F | PHE186 |
F | VAL224 |
F | LEU225 |
F | TYR261 |
F | HOH561 |
F | HOH1455 |
F | HOH1776 |
site_id | DC3 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE CPS F 5091 |
Chain | Residue |
C | TRP167 |
D | HOH2044 |
F | HIS223 |
F | GLN228 |
F | HIS229 |
F | PHE240 |
F | HOH491 |
F | HOH492 |
F | HOH493 |
F | HOH571 |
F | HOH588 |
F | HOH616 |
F | HOH743 |
F | HOH816 |
F | HOH1100 |
F | HOH1237 |
F | HOH1260 |
F | HOH1547 |
F | HOH1762 |
F | HOH1816 |
F | RXP6006 |
site_id | DC4 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE RXP A 6001 |
Chain | Residue |
A | LEU172 |
A | GLY179 |
A | ILE180 |
A | LEU181 |
A | ALA182 |
A | ALA184 |
A | GLN215 |
A | VAL216 |
A | HIS219 |
A | GLU220 |
A | HIS223 |
A | HIS229 |
A | SER238 |
A | PRO239 |
A | PHE240 |
A | TYR241 |
A | CPS5001 |
A | ZN5502 |
A | HOH6035 |
A | HOH6041 |
A | HOH6148 |
A | HOH6149 |
A | HOH6301 |
site_id | DC5 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE RXP B 6002 |
Chain | Residue |
B | LEU172 |
B | GLY179 |
B | ILE180 |
B | LEU181 |
B | ALA182 |
B | ALA184 |
B | GLN215 |
B | HIS219 |
B | GLU220 |
B | HIS223 |
B | HIS229 |
B | LEU236 |
B | SER238 |
B | PRO239 |
B | PHE240 |
B | TYR241 |
B | CPS5002 |
B | ZN5505 |
B | HOH6103 |
B | HOH6113 |
B | HOH6300 |
site_id | DC6 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE RXP C 6003 |
Chain | Residue |
C | GLY179 |
C | ILE180 |
C | LEU181 |
C | ALA182 |
C | ALA184 |
C | GLN215 |
C | HIS219 |
C | GLU220 |
C | HIS223 |
C | HIS229 |
C | LEU236 |
C | SER238 |
C | PRO239 |
C | PHE240 |
C | TYR241 |
C | CPS5003 |
C | ZN5508 |
C | HOH6050 |
C | HOH6155 |
C | HOH6254 |
site_id | DC7 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE RXP D 6004 |
Chain | Residue |
D | GLY179 |
D | ILE180 |
D | LEU181 |
D | ALA182 |
D | ALA184 |
D | GLN215 |
D | HIS219 |
D | GLU220 |
D | HIS223 |
D | HIS229 |
D | LEU236 |
D | SER238 |
D | PRO239 |
D | PHE240 |
D | TYR241 |
D | HOH488 |
D | HOH685 |
D | HOH686 |
D | HOH757 |
D | HOH837 |
D | ZN5511 |
site_id | DC8 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE RXP E 6005 |
Chain | Residue |
E | GLY179 |
E | ILE180 |
E | LEU181 |
E | ALA182 |
E | ALA184 |
E | GLN215 |
E | HIS219 |
E | GLU220 |
E | HIS223 |
E | HIS229 |
E | LEU236 |
E | SER238 |
E | PRO239 |
E | PHE240 |
E | TYR241 |
E | CPS5005 |
E | ZN5514 |
E | HOH6013 |
E | HOH6088 |
E | HOH6089 |
E | HOH6090 |
E | HOH6108 |
E | HOH6218 |
E | HOH6342 |
site_id | DC9 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE RXP F 6006 |
Chain | Residue |
D | HOH995 |
F | LEU172 |
F | GLY179 |
F | ILE180 |
F | LEU181 |
F | ALA182 |
F | ALA184 |
F | HIS219 |
F | GLU220 |
F | HIS229 |
F | LEU236 |
F | SER238 |
F | PRO239 |
F | PHE240 |
F | TYR241 |
F | HOH498 |
F | HOH1044 |
F | CPS5091 |
F | ZN5517 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHVL |
Chain | Residue | Details |
A | VAL216-LEU225 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | GLU220 | |
B | GLU220 | |
C | GLU220 | |
D | GLU220 | |
E | GLU220 | |
F | GLU220 |
site_id | SWS_FT_FI2 |
Number of Residues | 66 |
Details | BINDING: |
Chain | Residue | Details |
A | HIS168 | |
A | HIS223 | |
A | HIS229 | |
B | HIS168 | |
B | ASP170 | |
B | ASP175 | |
B | GLY176 | |
B | GLY178 | |
B | ILE180 | |
B | HIS183 | |
B | HIS196 | |
A | ASP170 | |
B | HIS219 | |
B | HIS223 | |
B | HIS229 | |
C | HIS168 | |
C | ASP170 | |
C | ASP175 | |
C | GLY176 | |
C | GLY178 | |
C | ILE180 | |
C | HIS183 | |
A | ASP175 | |
C | HIS196 | |
C | HIS219 | |
C | HIS223 | |
C | HIS229 | |
D | HIS168 | |
D | ASP170 | |
D | ASP175 | |
D | GLY176 | |
D | GLY178 | |
D | ILE180 | |
A | GLY176 | |
D | HIS183 | |
D | HIS196 | |
D | HIS219 | |
D | HIS223 | |
D | HIS229 | |
E | HIS168 | |
E | ASP170 | |
E | ASP175 | |
E | GLY176 | |
E | GLY178 | |
A | GLY178 | |
E | ILE180 | |
E | HIS183 | |
E | HIS196 | |
E | HIS219 | |
E | HIS223 | |
E | HIS229 | |
F | HIS168 | |
F | ASP170 | |
F | ASP175 | |
F | GLY176 | |
A | ILE180 | |
F | GLY178 | |
F | ILE180 | |
F | HIS183 | |
F | HIS196 | |
F | HIS219 | |
F | HIS223 | |
F | HIS229 | |
A | HIS183 | |
A | HIS196 | |
A | HIS219 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | MET237 | |
A | GLU220 |
site_id | CSA10 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
D | GLU220 |
site_id | CSA11 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
E | GLU220 |
site_id | CSA12 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
F | GLU220 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | MET237 | |
B | GLU220 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
C | MET237 | |
C | GLU220 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
D | MET237 | |
D | GLU220 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
E | MET237 | |
E | GLU220 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
F | MET237 | |
F | GLU220 |
site_id | CSA7 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | GLU220 |
site_id | CSA8 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | GLU220 |
site_id | CSA9 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
C | GLU220 |