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1HUO

CRYSTAL STRUCTURE OF DNA POLYMERASE BETA COMPLEXED WITH DNA AND CR-TMPPCP

Replaces:  1CF6
Functional Information from GO Data
ChainGOidnamespacecontents
A0001701biological_processin utero embryonic development
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005874cellular_componentmicrotubule
A0005876cellular_componentspindle microtubule
A0006259biological_processDNA metabolic process
A0006260biological_processDNA replication
A0006281biological_processDNA repair
A0006284biological_processbase-excision repair
A0006287biological_processbase-excision repair, gap-filling
A0006290biological_processpyrimidine dimer repair
A0006297biological_processnucleotide-excision repair, DNA gap filling
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0006974biological_processDNA damage response
A0007435biological_processsalivary gland morphogenesis
A0008017molecular_functionmicrotubule binding
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0009059biological_processmacromolecule biosynthetic process
A0010332biological_processresponse to gamma radiation
A0016445biological_processsomatic diversification of immunoglobulins
A0016446biological_processsomatic hypermutation of immunoglobulin genes
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0016829molecular_functionlyase activity
A0019899molecular_functionenzyme binding
A0032991cellular_componentprotein-containing complex
A0034061molecular_functionDNA polymerase activity
A0045471biological_processresponse to ethanol
A0046872molecular_functionmetal ion binding
A0048535biological_processlymph node development
A0048536biological_processspleen development
A0048872biological_processhomeostasis of number of cells
A0051402biological_processneuron apoptotic process
A0051575molecular_function5'-deoxyribose-5-phosphate lyase activity
A0055093biological_processresponse to hyperoxia
A0071707biological_processimmunoglobulin heavy chain V-D-J recombination
A0071897biological_processDNA biosynthetic process
A0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
B0001701biological_processin utero embryonic development
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0003887molecular_functionDNA-directed DNA polymerase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005874cellular_componentmicrotubule
B0005876cellular_componentspindle microtubule
B0006259biological_processDNA metabolic process
B0006260biological_processDNA replication
B0006281biological_processDNA repair
B0006284biological_processbase-excision repair
B0006287biological_processbase-excision repair, gap-filling
B0006290biological_processpyrimidine dimer repair
B0006297biological_processnucleotide-excision repair, DNA gap filling
B0006303biological_processdouble-strand break repair via nonhomologous end joining
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0006974biological_processDNA damage response
B0007435biological_processsalivary gland morphogenesis
B0008017molecular_functionmicrotubule binding
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0009059biological_processmacromolecule biosynthetic process
B0010332biological_processresponse to gamma radiation
B0016445biological_processsomatic diversification of immunoglobulins
B0016446biological_processsomatic hypermutation of immunoglobulin genes
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0016829molecular_functionlyase activity
B0019899molecular_functionenzyme binding
B0032991cellular_componentprotein-containing complex
B0034061molecular_functionDNA polymerase activity
B0045471biological_processresponse to ethanol
B0046872molecular_functionmetal ion binding
B0048535biological_processlymph node development
B0048536biological_processspleen development
B0048872biological_processhomeostasis of number of cells
B0051402biological_processneuron apoptotic process
B0051575molecular_function5'-deoxyribose-5-phosphate lyase activity
B0055093biological_processresponse to hyperoxia
B0071707biological_processimmunoglobulin heavy chain V-D-J recombination
B0071897biological_processDNA biosynthetic process
B0140078molecular_functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CR A 999
ChainResidue
AASP190
AASP192
ATTE338

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CR B 999
ChainResidue
BASP190
BASP192
BTTE338

site_idAC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE TTE B 338
ChainResidue
BARG183
BSER188
BGLY189
BASP190
BASP192
BTYR271
BPHE272
BTHR273
BSER275
BASP276
BASN279
BCR999
CDA4
CDG5
DDC7
BARG149
BGLY179
BSER180

site_idAC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE TTE A 338
ChainResidue
AARG149
AGLY179
ASER180
AARG183
ASER188
AGLY189
AASP190
AASP192
ATYR271
APHE272
ATHR273
AASP276
ACR999
PDC7
TDA4

Functional Information from PROSITE/UniProt
site_idPS00522
Number of Residues20
DetailsDNA_POLYMERASE_X DNA polymerase family X signature. GSFrRGaesSgDMDVLLthP
ChainResidueDetails
AGLY179-PRO198

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity => ECO:0000250|UniProtKB:P06746
ChainResidueDetails
ALYS72
BLYS72

site_idSWS_FT_FI2
Number of Residues26
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P06746
ChainResidueDetails
ALYS60
AGLY189
AASP190
AASP192
AASP256
BLYS60
BLEU62
BVAL65
BTHR101
BVAL103
BILE106
ALEU62
BARG149
BSER180
BARG183
BGLY189
BASP190
BASP192
BASP256
AVAL65
ATHR101
AVAL103
AILE106
AARG149
ASER180
AARG183

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8K409
ChainResidueDetails
ALYS72
BLYS72

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Omega-N-methylarginine; by PRMT6 => ECO:0000250|UniProtKB:P06746
ChainResidueDetails
AARG83
AARG152
BARG83
BARG152

site_idSWS_FT_FI5
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P06746
ChainResidueDetails
ALYS41
ALYS61
ALYS81
BLYS41
BLYS61
BLYS81

218853

PDB entries from 2024-04-24

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