Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1HT2

Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0009376	cellular_component	HslUV protease complex
A	0009408	biological_process	response to heat
A	0019904	molecular_function	protein domain specific binding
A	0030163	biological_process	protein catabolic process
A	0030164	biological_process	protein denaturation
A	0034605	biological_process	cellular response to heat
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000287	molecular_function	magnesium ion binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0009376	cellular_component	HslUV protease complex
B	0009408	biological_process	response to heat
B	0019904	molecular_function	protein domain specific binding
B	0030163	biological_process	protein catabolic process
B	0030164	biological_process	protein denaturation
B	0034605	biological_process	cellular response to heat
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000287	molecular_function	magnesium ion binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0009376	cellular_component	HslUV protease complex
C	0009408	biological_process	response to heat
C	0019904	molecular_function	protein domain specific binding
C	0030163	biological_process	protein catabolic process
C	0030164	biological_process	protein denaturation
C	0034605	biological_process	cellular response to heat
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000287	molecular_function	magnesium ion binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0009376	cellular_component	HslUV protease complex
D	0009408	biological_process	response to heat
D	0019904	molecular_function	protein domain specific binding
D	0030163	biological_process	protein catabolic process
D	0030164	biological_process	protein denaturation
D	0034605	biological_process	cellular response to heat
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000287	molecular_function	magnesium ion binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006508	biological_process	proteolysis
E	0008233	molecular_function	peptidase activity
E	0009376	cellular_component	HslUV protease complex
E	0009408	biological_process	response to heat
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0019904	molecular_function	protein domain specific binding
E	0030164	biological_process	protein denaturation
E	0034605	biological_process	cellular response to heat
E	0036402	molecular_function	proteasome-activating activity
E	0042802	molecular_function	identical protein binding
E	0043335	biological_process	protein unfolding
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	1901800	biological_process	positive regulation of proteasomal protein catabolic process
F	0000287	molecular_function	magnesium ion binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006508	biological_process	proteolysis
F	0008233	molecular_function	peptidase activity
F	0009376	cellular_component	HslUV protease complex
F	0009408	biological_process	response to heat
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0019904	molecular_function	protein domain specific binding
F	0030164	biological_process	protein denaturation
F	0034605	biological_process	cellular response to heat
F	0036402	molecular_function	proteasome-activating activity
F	0042802	molecular_function	identical protein binding
F	0043335	biological_process	protein unfolding
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	1901800	biological_process	positive regulation of proteasomal protein catabolic process
G	0000287	molecular_function	magnesium ion binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006508	biological_process	proteolysis
G	0008233	molecular_function	peptidase activity
G	0009376	cellular_component	HslUV protease complex
G	0009408	biological_process	response to heat
G	0016020	cellular_component	membrane
G	0016887	molecular_function	ATP hydrolysis activity
G	0019904	molecular_function	protein domain specific binding
G	0030164	biological_process	protein denaturation
G	0034605	biological_process	cellular response to heat
G	0036402	molecular_function	proteasome-activating activity
G	0042802	molecular_function	identical protein binding
G	0043335	biological_process	protein unfolding
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	1901800	biological_process	positive regulation of proteasomal protein catabolic process
H	0000287	molecular_function	magnesium ion binding
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006508	biological_process	proteolysis
H	0008233	molecular_function	peptidase activity
H	0009376	cellular_component	HslUV protease complex
H	0009408	biological_process	response to heat
H	0016020	cellular_component	membrane
H	0016887	molecular_function	ATP hydrolysis activity
H	0019904	molecular_function	protein domain specific binding
H	0030164	biological_process	protein denaturation
H	0034605	biological_process	cellular response to heat
H	0036402	molecular_function	proteasome-activating activity
H	0042802	molecular_function	identical protein binding
H	0043335	biological_process	protein unfolding
H	0051603	biological_process	proteolysis involved in protein catabolic process
H	1901800	biological_process	positive regulation of proteasomal protein catabolic process
I	0000287	molecular_function	magnesium ion binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0006508	biological_process	proteolysis
I	0008233	molecular_function	peptidase activity
I	0009376	cellular_component	HslUV protease complex
I	0009408	biological_process	response to heat
I	0019904	molecular_function	protein domain specific binding
I	0030163	biological_process	protein catabolic process
I	0030164	biological_process	protein denaturation
I	0034605	biological_process	cellular response to heat
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000287	molecular_function	magnesium ion binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0006508	biological_process	proteolysis
J	0008233	molecular_function	peptidase activity
J	0009376	cellular_component	HslUV protease complex
J	0009408	biological_process	response to heat
J	0019904	molecular_function	protein domain specific binding
J	0030163	biological_process	protein catabolic process
J	0030164	biological_process	protein denaturation
J	0034605	biological_process	cellular response to heat
J	0042802	molecular_function	identical protein binding
J	0046872	molecular_function	metal ion binding
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000287	molecular_function	magnesium ion binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0006508	biological_process	proteolysis
K	0008233	molecular_function	peptidase activity
K	0009376	cellular_component	HslUV protease complex
K	0009408	biological_process	response to heat
K	0019904	molecular_function	protein domain specific binding
K	0030163	biological_process	protein catabolic process
K	0030164	biological_process	protein denaturation
K	0034605	biological_process	cellular response to heat
K	0042802	molecular_function	identical protein binding
K	0046872	molecular_function	metal ion binding
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0000287	molecular_function	magnesium ion binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005839	cellular_component	proteasome core complex
L	0006508	biological_process	proteolysis
L	0008233	molecular_function	peptidase activity
L	0009376	cellular_component	HslUV protease complex
L	0009408	biological_process	response to heat
L	0019904	molecular_function	protein domain specific binding
L	0030163	biological_process	protein catabolic process
L	0030164	biological_process	protein denaturation
L	0034605	biological_process	cellular response to heat
L	0042802	molecular_function	identical protein binding
L	0046872	molecular_function	metal ion binding
L	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP E 450

Chain	Residue
E	HIS16
E	ILE343
E	ALA392
E	ARG393
E	ILE17
E	ILE18
E	GLY60
E	VAL61
E	GLY62
E	LYS63
E	THR64
E	GLU65

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP F 1450

Chain	Residue
F	HIS16
F	ILE17
F	ILE18
F	THR59
F	GLY60
F	VAL61
F	GLY62
F	LYS63
F	THR64
F	GLU65
F	LEU335
F	ILE343
F	ALA392
F	ARG393

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP G 2450

Chain	Residue
G	HIS16
G	ILE17
G	ILE18
G	THR59
G	GLY60
G	VAL61
G	GLY62
G	LYS63
G	THR64
G	GLU65
G	LEU335
G	ILE343
G	ALA392
G	ARG393

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP H 3450

Chain	Residue
H	HIS16
H	ILE17
H	ILE18
H	GLY60
H	VAL61
H	GLY62
H	LYS63
H	THR64
H	GLU65
H	LEU335
H	ALA392
H	ARG393

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING:

Chain	Residue	Details
E	ILE18
F	ARG393
G	ILE18
G	GLY60
G	ASP256
G	GLU321
G	ARG393
H	ILE18
H	GLY60
H	ASP256
H	GLU321
E	GLY60
H	ARG393
E	ASP256
E	GLU321
E	ARG393
F	ILE18
F	GLY60
F	ASP256
F	GLU321

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
A	ASP157
D	ASP157
D	ILE160
D	ASN163
I	ASP157
I	ILE160
I	ASN163
J	ASP157
J	ILE160
J	ASN163
K	ASP157
A	ILE160
K	ILE160
K	ASN163
L	ASP157
L	ILE160
L	ASN163
A	ASN163
B	ASP157
B	ILE160
B	ASN163
C	ASP157
C	ILE160
C	ASN163

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
A	GLY48
A	LYS33
A	THR1
A	SER124

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
B	GLY48
B	LYS33
B	THR1
B	SER124

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
C	GLY48
C	LYS33
C	THR1
C	SER124

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
D	GLY48
D	LYS33
D	THR1
D	SER124

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
I	GLY48
I	LYS33
I	THR1
I	SER124

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
J	GLY48
J	LYS33
J	THR1
J	SER124

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
K	GLY48
K	LYS33
K	THR1
K	SER124

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
L	GLY48
L	LYS33
L	THR1
L	SER124

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
A	GLY45
A	LYS33
A	THR1
A	SER124

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
B	GLY45
B	LYS33
B	THR1
B	SER124

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
C	GLY45
C	LYS33
C	THR1
C	SER124

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
D	GLY45
D	LYS33
D	THR1
D	SER124

site_id	CSA13
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
I	GLY45
I	LYS33
I	THR1
I	SER124

site_id	CSA14
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
J	GLY45
J	LYS33
J	THR1
J	SER124

site_id	CSA15
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
K	GLY45
K	LYS33
K	THR1
K	SER124

site_id	CSA16
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
L	GLY45
L	LYS33
L	THR1
L	SER124

site_id	CSA17
Number of Residues	3
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
E	LYS140
E	LYS240
E	LYS63

site_id	CSA18
Number of Residues	3
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
F	LYS140
F	LYS240
F	LYS63

site_id	CSA19
Number of Residues	3
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
G	LYS140
G	LYS240
G	LYS63

site_id	CSA20
Number of Residues	3
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
H	LYS140
H	LYS240
H	LYS63

site_id	MCSA1
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
A	THR2	proton acceptor, proton donor
A	VAL34	electrostatic stabiliser
A	PHE46	electrostatic stabiliser
A	GLY125	electrostatic stabiliser

site_id	MCSA2
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
B	THR2	proton acceptor, proton donor
B	VAL34	electrostatic stabiliser
B	PHE46	electrostatic stabiliser
B	GLY125	electrostatic stabiliser

site_id	MCSA3
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
C	THR2	proton acceptor, proton donor
C	VAL34	electrostatic stabiliser
C	PHE46	electrostatic stabiliser
C	GLY125	electrostatic stabiliser

site_id	MCSA4
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
D	THR2	proton acceptor, proton donor
D	VAL34	electrostatic stabiliser
D	PHE46	electrostatic stabiliser
D	GLY125	electrostatic stabiliser

site_id	MCSA5
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
I	THR2	proton acceptor, proton donor
I	VAL34	electrostatic stabiliser
I	PHE46	electrostatic stabiliser
I	GLY125	electrostatic stabiliser

site_id	MCSA6
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
J	THR2	proton acceptor, proton donor
J	VAL34	electrostatic stabiliser
J	PHE46	electrostatic stabiliser
J	GLY125	electrostatic stabiliser

site_id	MCSA7
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
K	THR2	proton acceptor, proton donor
K	VAL34	electrostatic stabiliser
K	PHE46	electrostatic stabiliser
K	GLY125	electrostatic stabiliser

site_id	MCSA8
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
L	THR2	proton acceptor, proton donor
L	VAL34	electrostatic stabiliser
L	PHE46	electrostatic stabiliser
L	GLY125	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)