Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1HT1

Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000502	cellular_component	proteasome complex
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0009376	cellular_component	HslUV protease complex
A	0009408	biological_process	response to heat
A	0019904	molecular_function	protein domain specific binding
A	0030163	biological_process	protein catabolic process
A	0030164	biological_process	protein denaturation
A	0034605	biological_process	cellular response to heat
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000287	molecular_function	magnesium ion binding
B	0000502	cellular_component	proteasome complex
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0009376	cellular_component	HslUV protease complex
B	0009408	biological_process	response to heat
B	0019904	molecular_function	protein domain specific binding
B	0030163	biological_process	protein catabolic process
B	0030164	biological_process	protein denaturation
B	0034605	biological_process	cellular response to heat
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000287	molecular_function	magnesium ion binding
C	0000502	cellular_component	proteasome complex
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0009376	cellular_component	HslUV protease complex
C	0009408	biological_process	response to heat
C	0019904	molecular_function	protein domain specific binding
C	0030163	biological_process	protein catabolic process
C	0030164	biological_process	protein denaturation
C	0034605	biological_process	cellular response to heat
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000287	molecular_function	magnesium ion binding
D	0000502	cellular_component	proteasome complex
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0009376	cellular_component	HslUV protease complex
D	0009408	biological_process	response to heat
D	0019904	molecular_function	protein domain specific binding
D	0030163	biological_process	protein catabolic process
D	0030164	biological_process	protein denaturation
D	0034605	biological_process	cellular response to heat
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000287	molecular_function	magnesium ion binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006508	biological_process	proteolysis
E	0008233	molecular_function	peptidase activity
E	0009376	cellular_component	HslUV protease complex
E	0009408	biological_process	response to heat
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0019904	molecular_function	protein domain specific binding
E	0030164	biological_process	protein denaturation
E	0034605	biological_process	cellular response to heat
E	0036402	molecular_function	proteasome-activating activity
E	0042802	molecular_function	identical protein binding
E	0043335	biological_process	protein unfolding
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	1901800	biological_process	positive regulation of proteasomal protein catabolic process
F	0000287	molecular_function	magnesium ion binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006508	biological_process	proteolysis
F	0008233	molecular_function	peptidase activity
F	0009376	cellular_component	HslUV protease complex
F	0009408	biological_process	response to heat
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0019904	molecular_function	protein domain specific binding
F	0030164	biological_process	protein denaturation
F	0034605	biological_process	cellular response to heat
F	0036402	molecular_function	proteasome-activating activity
F	0042802	molecular_function	identical protein binding
F	0043335	biological_process	protein unfolding
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	1901800	biological_process	positive regulation of proteasomal protein catabolic process
G	0000287	molecular_function	magnesium ion binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006508	biological_process	proteolysis
G	0008233	molecular_function	peptidase activity
G	0009376	cellular_component	HslUV protease complex
G	0009408	biological_process	response to heat
G	0016020	cellular_component	membrane
G	0016887	molecular_function	ATP hydrolysis activity
G	0019904	molecular_function	protein domain specific binding
G	0030164	biological_process	protein denaturation
G	0034605	biological_process	cellular response to heat
G	0036402	molecular_function	proteasome-activating activity
G	0042802	molecular_function	identical protein binding
G	0043335	biological_process	protein unfolding
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	1901800	biological_process	positive regulation of proteasomal protein catabolic process
I	0000287	molecular_function	magnesium ion binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006508	biological_process	proteolysis
I	0008233	molecular_function	peptidase activity
I	0009376	cellular_component	HslUV protease complex
I	0009408	biological_process	response to heat
I	0016020	cellular_component	membrane
I	0016887	molecular_function	ATP hydrolysis activity
I	0019904	molecular_function	protein domain specific binding
I	0030164	biological_process	protein denaturation
I	0034605	biological_process	cellular response to heat
I	0036402	molecular_function	proteasome-activating activity
I	0042802	molecular_function	identical protein binding
I	0043335	biological_process	protein unfolding
I	0051603	biological_process	proteolysis involved in protein catabolic process
I	1901800	biological_process	positive regulation of proteasomal protein catabolic process
V	0000287	molecular_function	magnesium ion binding
V	0000502	cellular_component	proteasome complex
V	0004176	molecular_function	ATP-dependent peptidase activity
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005515	molecular_function	protein binding
V	0005524	molecular_function	ATP binding
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005839	cellular_component	proteasome core complex
V	0006508	biological_process	proteolysis
V	0008233	molecular_function	peptidase activity
V	0009376	cellular_component	HslUV protease complex
V	0009408	biological_process	response to heat
V	0019904	molecular_function	protein domain specific binding
V	0030163	biological_process	protein catabolic process
V	0030164	biological_process	protein denaturation
V	0034605	biological_process	cellular response to heat
V	0042802	molecular_function	identical protein binding
V	0046872	molecular_function	metal ion binding
V	0051603	biological_process	proteolysis involved in protein catabolic process
X	0000287	molecular_function	magnesium ion binding
X	0000502	cellular_component	proteasome complex
X	0004176	molecular_function	ATP-dependent peptidase activity
X	0004298	molecular_function	threonine-type endopeptidase activity
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0006508	biological_process	proteolysis
X	0008233	molecular_function	peptidase activity
X	0009376	cellular_component	HslUV protease complex
X	0009408	biological_process	response to heat
X	0019904	molecular_function	protein domain specific binding
X	0030163	biological_process	protein catabolic process
X	0030164	biological_process	protein denaturation
X	0034605	biological_process	cellular response to heat
X	0042802	molecular_function	identical protein binding
X	0046872	molecular_function	metal ion binding
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0000287	molecular_function	magnesium ion binding
Y	0000502	cellular_component	proteasome complex
Y	0004176	molecular_function	ATP-dependent peptidase activity
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005515	molecular_function	protein binding
Y	0005524	molecular_function	ATP binding
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0006508	biological_process	proteolysis
Y	0008233	molecular_function	peptidase activity
Y	0009376	cellular_component	HslUV protease complex
Y	0009408	biological_process	response to heat
Y	0019904	molecular_function	protein domain specific binding
Y	0030163	biological_process	protein catabolic process
Y	0030164	biological_process	protein denaturation
Y	0034605	biological_process	cellular response to heat
Y	0042802	molecular_function	identical protein binding
Y	0046872	molecular_function	metal ion binding
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0000287	molecular_function	magnesium ion binding
Z	0000502	cellular_component	proteasome complex
Z	0004176	molecular_function	ATP-dependent peptidase activity
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005515	molecular_function	protein binding
Z	0005524	molecular_function	ATP binding
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005839	cellular_component	proteasome core complex
Z	0006508	biological_process	proteolysis
Z	0008233	molecular_function	peptidase activity
Z	0009376	cellular_component	HslUV protease complex
Z	0009408	biological_process	response to heat
Z	0019904	molecular_function	protein domain specific binding
Z	0030163	biological_process	protein catabolic process
Z	0030164	biological_process	protein denaturation
Z	0034605	biological_process	cellular response to heat
Z	0042802	molecular_function	identical protein binding
Z	0046872	molecular_function	metal ion binding
Z	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP E 450

Chain	Residue
E	HIS16
E	LEU335
E	ILE343
E	ALA392
E	ARG393
E	ILE17
E	ILE18
E	GLY60
E	VAL61
E	GLY62
E	LYS63
E	THR64
E	GLU65

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP F 1450

Chain	Residue
F	HIS16
F	ILE17
F	ILE18
F	THR59
F	GLY60
F	VAL61
F	GLY62
F	LYS63
F	THR64
F	GLU65
F	LEU335
F	ILE343
F	ALA392
F	ARG393

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP G 2450

Chain	Residue
G	HIS16
G	ILE17
G	ILE18
G	THR59
G	GLY60
G	VAL61
G	GLY62
G	LYS63
G	THR64
G	GLU65
G	LEU335
G	ILE343
G	ALA392
G	ARG393

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP I 3450

Chain	Residue
I	HIS16
I	ILE17
I	ILE18
I	GLY60
I	VAL61
I	GLY62
I	LYS63
I	THR64
I	GLU65
I	LEU335
I	ILE343
I	ALA392
I	ARG393

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING:

Chain	Residue	Details
E	ILE18
F	ARG393
G	ILE18
G	GLY60
G	ASP256
G	GLU321
G	ARG393
I	ILE18
I	GLY60
I	ASP256
I	GLU321
E	GLY60
I	ARG393
E	ASP256
E	GLU321
E	ARG393
F	ILE18
F	GLY60
F	ASP256
F	GLU321

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
C	ASP157
X	ASP157
X	ILE160
X	ASN163
A	ASP157
A	ILE160
A	ASN163
B	ASP157
B	ILE160
B	ASN163
Z	ASP157
C	ILE160
Z	ILE160
Z	ASN163
Y	ASP157
Y	ILE160
Y	ASN163
C	ASN163
D	ASP157
D	ILE160
D	ASN163
V	ASP157
V	ILE160
V	ASN163

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
C	GLY48
C	LYS33
C	THR1
C	SER124

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
D	GLY45
D	LYS33
D	THR1
D	SER124

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
V	GLY45
V	LYS33
V	THR1
V	SER124

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
X	GLY45
X	LYS33
X	THR1
X	SER124

site_id	CSA13
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
A	GLY45
A	LYS33
A	THR1
A	SER124

site_id	CSA14
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
B	GLY45
B	LYS33
B	THR1
B	SER124

site_id	CSA15
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
Z	GLY45
Z	LYS33
Z	THR1
Z	SER124

site_id	CSA16
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
Y	GLY45
Y	LYS33
Y	THR1
Y	SER124

site_id	CSA17
Number of Residues	3
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
E	LYS140
E	LYS240
E	LYS63

site_id	CSA18
Number of Residues	3
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
F	LYS140
F	LYS240
F	LYS63

site_id	CSA19
Number of Residues	3
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
G	LYS140
G	LYS240
G	LYS63

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
D	GLY48
D	LYS33
D	THR1
D	SER124

site_id	CSA20
Number of Residues	3
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
I	LYS140
I	LYS240
I	LYS63

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
V	GLY48
V	LYS33
V	THR1
V	SER124

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
X	GLY48
X	LYS33
X	THR1
X	SER124

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
A	GLY48
A	LYS33
A	THR1
A	SER124

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
B	GLY48
B	LYS33
B	THR1
B	SER124

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
Z	GLY48
Z	LYS33
Z	THR1
Z	SER124

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
Y	GLY48
Y	LYS33
Y	THR1
Y	SER124

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
C	GLY45
C	LYS33
C	THR1
C	SER124

site_id	MCSA1
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
C	THR2	proton acceptor, proton donor
C	VAL34	electrostatic stabiliser
C	PHE46	electrostatic stabiliser
C	GLY125	electrostatic stabiliser

site_id	MCSA2
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
D	THR2	proton acceptor, proton donor
D	VAL34	electrostatic stabiliser
D	PHE46	electrostatic stabiliser
D	GLY125	electrostatic stabiliser

site_id	MCSA3
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
V	THR2	proton acceptor, proton donor
V	VAL34	electrostatic stabiliser
V	PHE46	electrostatic stabiliser
V	GLY125	electrostatic stabiliser

site_id	MCSA4
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
X	THR2	proton acceptor, proton donor
X	VAL34	electrostatic stabiliser
X	PHE46	electrostatic stabiliser
X	GLY125	electrostatic stabiliser

site_id	MCSA5
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
A	THR2	proton acceptor, proton donor
A	VAL34	electrostatic stabiliser
A	PHE46	electrostatic stabiliser
A	GLY125	electrostatic stabiliser

site_id	MCSA6
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
B	THR2	proton acceptor, proton donor
B	VAL34	electrostatic stabiliser
B	PHE46	electrostatic stabiliser
B	GLY125	electrostatic stabiliser

site_id	MCSA7
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
Z	THR2	proton acceptor, proton donor
Z	VAL34	electrostatic stabiliser
Z	PHE46	electrostatic stabiliser
Z	GLY125	electrostatic stabiliser

site_id	MCSA8
Number of Residues	4
Details	M-CSA 678

Chain	Residue	Details
Y	THR2	proton acceptor, proton donor
Y	VAL34	electrostatic stabiliser
Y	PHE46	electrostatic stabiliser
Y	GLY125	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)