1HRK
CRYSTAL STRUCTURE OF HUMAN FERROCHELATASE
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CHD A 1501 |
| Chain | Residue |
| A | LEU92 |
| A | HOH1544 |
| A | HOH1559 |
| A | HOH1569 |
| A | HOH1595 |
| A | HOH1633 |
| A | HOH1763 |
| A | LEU98 |
| A | SER197 |
| A | HIS263 |
| A | LEU265 |
| A | PRO266 |
| A | VAL269 |
| A | TRP310 |
| A | CHD1502 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CHD A 1502 |
| Chain | Residue |
| A | MET99 |
| A | ARG114 |
| A | LEU115 |
| A | PRO266 |
| A | MET308 |
| A | CHD1501 |
| A | CHD1503 |
| A | HOH1622 |
| A | HOH1679 |
| A | HOH1685 |
| A | HOH1698 |
| A | HOH1713 |
| A | HOH1726 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CHD A 1503 |
| Chain | Residue |
| A | LEU107 |
| A | CHD1502 |
| A | HOH1698 |
| A | HOH1726 |
| B | PHE110 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE CHD B 2501 |
| Chain | Residue |
| B | LEU92 |
| B | PHE93 |
| B | LEU98 |
| B | SER197 |
| B | HIS263 |
| B | LEU265 |
| B | PRO266 |
| B | VAL269 |
| B | TRP310 |
| B | CHD2502 |
| B | HOH3079 |
| B | HOH3091 |
| B | HOH3092 |
| B | HOH3094 |
| B | HOH3112 |
| B | HOH3218 |
| B | HOH3281 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CHD B 2502 |
| Chain | Residue |
| B | MET99 |
| B | ARG114 |
| B | LEU115 |
| B | PRO266 |
| B | MET308 |
| B | CHD2501 |
| B | CHD2503 |
| B | HOH3157 |
| B | HOH3173 |
| B | HOH3214 |
| B | HOH3219 |
| B | HOH3264 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CHD B 2503 |
| Chain | Residue |
| A | LYS106 |
| A | PHE110 |
| B | LEU101 |
| B | ARG114 |
| B | CHD2502 |
| B | HOH3173 |
| B | HOH3219 |
| B | HOH3298 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FES A 1499 |
| Chain | Residue |
| A | CYS196 |
| A | ARG272 |
| A | SER402 |
| A | CYS403 |
| A | CYS406 |
| A | CYS411 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FES B 2999 |
| Chain | Residue |
| B | CYS196 |
| B | ARG272 |
| B | SER402 |
| B | CYS403 |
| B | CYS406 |
| B | CYS411 |
Functional Information from PROSITE/UniProt
| site_id | PS00534 |
| Number of Residues | 19 |
| Details | FERROCHELATASE Ferrochelatase signature. ILfSaHSLPmsvv.NrGDp...Y |
| Chain | Residue | Details |
| A | ILE258-TYR276 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17261801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HRE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17261801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HRK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HRC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HRK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P22315","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P22315","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 11175906, 11502175, 1175906 |
| Chain | Residue | Details |
| A | HIS263 | |
| A | GLU343 | |
| A | GLU347 | |
| A | ASP340 | |
| A | ARG164 | |
| A | TYR165 |
| site_id | MCSA1 |
| Number of Residues | 9 |
| Details | M-CSA 578 |
| Chain | Residue | Details |
| A | MET76 | |
| A | LEU92 | |
| A | LEU98 | |
| A | ARG164 | |
| A | TYR165 | |
| A | HIS263 | metal ligand, proton acceptor |
| A | ASP340 | |
| A | GLU343 | metal ligand, proton acceptor |
| A | GLU347 |
| site_id | MCSA2 |
| Number of Residues | 9 |
| Details | M-CSA 578 |
| Chain | Residue | Details |
| B | MET76 | |
| B | LEU92 | |
| B | LEU98 | |
| B | ARG164 | |
| B | TYR165 | |
| B | HIS263 | metal ligand, proton acceptor |
| B | ASP340 | |
| B | GLU343 | metal ligand, proton acceptor |
| B | GLU347 |
