1HRD

GLUTAMATE DEHYDROGENASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004352	molecular_function	glutamate dehydrogenase (NAD+) activity
A	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
A	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0006537	biological_process	glutamate biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
A	0019552	biological_process	L-glutamate catabolic process via 2-hydroxyglutarate
A	0055114	biological_process	obsolete oxidation-reduction process
B	0004352	molecular_function	glutamate dehydrogenase (NAD+) activity
B	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
B	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
B	0005829	cellular_component	cytosol
B	0006520	biological_process	amino acid metabolic process
B	0006537	biological_process	glutamate biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
B	0019552	biological_process	L-glutamate catabolic process via 2-hydroxyglutarate
B	0055114	biological_process	obsolete oxidation-reduction process
C	0004352	molecular_function	glutamate dehydrogenase (NAD+) activity
C	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
C	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0006537	biological_process	glutamate biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
C	0019552	biological_process	L-glutamate catabolic process via 2-hydroxyglutarate
C	0055114	biological_process	obsolete oxidation-reduction process

Functional Information from PROSITE/UniProt

site_id	PS00074
Number of Residues	14
Details	GLFV_DEHYDROGENASE Glu / Leu / Phe / Val dehydrogenases active site. LpmGGAKgGsdfDP

Chain	Residue	Details
A	LEU119-PRO132

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10011","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8263917","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8263917","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Site: {"description":"Important for catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 8037659, 8263917

Chain	Residue	Details
A	ASP165
A	LYS125

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site_id	MCSA1
Number of Residues	2
Details	M-CSA 579

Chain	Residue	Details
A	LYS125	electrostatic stabiliser, proton acceptor, proton donor
A	ASP165	proton acceptor, proton donor

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site_id	MCSA2
Number of Residues	2
Details	M-CSA 579

Chain	Residue	Details
B	LYS125	electrostatic stabiliser, proton acceptor, proton donor
B	ASP165	proton acceptor, proton donor

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site_id	MCSA3
Number of Residues	2
Details	M-CSA 579

Chain	Residue	Details
C	LYS125	electrostatic stabiliser, proton acceptor, proton donor
C	ASP165	proton acceptor, proton donor

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