Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1HR7

Yeast Mitochondrial Processing Peptidase beta-E73Q Mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006508	biological_process	proteolysis
A	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
A	0017087	cellular_component	mitochondrial processing peptidase complex
A	0046872	molecular_function	metal ion binding
A	0061133	molecular_function	endopeptidase activator activity
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006508	biological_process	proteolysis
B	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
B	0008233	molecular_function	peptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0009003	molecular_function	signal peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0017087	cellular_component	mitochondrial processing peptidase complex
B	0046872	molecular_function	metal ion binding
C	0004222	molecular_function	metalloendopeptidase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006508	biological_process	proteolysis
C	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
C	0017087	cellular_component	mitochondrial processing peptidase complex
C	0046872	molecular_function	metal ion binding
C	0061133	molecular_function	endopeptidase activator activity
D	0004222	molecular_function	metalloendopeptidase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006508	biological_process	proteolysis
D	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
D	0008233	molecular_function	peptidase activity
D	0008237	molecular_function	metallopeptidase activity
D	0008270	molecular_function	zinc ion binding
D	0009003	molecular_function	signal peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0017087	cellular_component	mitochondrial processing peptidase complex
D	0046872	molecular_function	metal ion binding
E	0004222	molecular_function	metalloendopeptidase activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006508	biological_process	proteolysis
E	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
E	0017087	cellular_component	mitochondrial processing peptidase complex
E	0046872	molecular_function	metal ion binding
E	0061133	molecular_function	endopeptidase activator activity
F	0004222	molecular_function	metalloendopeptidase activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006508	biological_process	proteolysis
F	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
F	0008233	molecular_function	peptidase activity
F	0008237	molecular_function	metallopeptidase activity
F	0008270	molecular_function	zinc ion binding
F	0009003	molecular_function	signal peptidase activity
F	0016787	molecular_function	hydrolase activity
F	0017087	cellular_component	mitochondrial processing peptidase complex
F	0046872	molecular_function	metal ion binding
G	0004222	molecular_function	metalloendopeptidase activity
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0006508	biological_process	proteolysis
G	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
G	0017087	cellular_component	mitochondrial processing peptidase complex
G	0046872	molecular_function	metal ion binding
G	0061133	molecular_function	endopeptidase activator activity
H	0004222	molecular_function	metalloendopeptidase activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006508	biological_process	proteolysis
H	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
H	0008233	molecular_function	peptidase activity
H	0008237	molecular_function	metallopeptidase activity
H	0008270	molecular_function	zinc ion binding
H	0009003	molecular_function	signal peptidase activity
H	0016787	molecular_function	hydrolase activity
H	0017087	cellular_component	mitochondrial processing peptidase complex
H	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 501

Chain	Residue
B	HIS70
B	HIS74
B	GLU150
B	HOH502

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 502

Chain	Residue
D	HIS70
D	HIS74
D	GLU150
D	HOH503

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 503

Chain	Residue
F	HIS74
F	GLU150
F	HOH504
F	HIS70

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 504

Chain	Residue
H	HOH4
H	HIS70
H	HIS74
H	GLU150

Functional Information from PROSITE/UniProt

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsrfegrnlkGcTHILDRLaFkST

Chain	Residue	Details
A	GLY49-THR72

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11470436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HR6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10096","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11470436","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9654444","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HR6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HR7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HR8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HR9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10096","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11470436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HR6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HR7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HR8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HR9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	a catalytic site defined by CSA, PubMed 11470436, 10595562

Chain	Residue	Details
B	GLN73

site_id	CSA2
Number of Residues	1
Details	a catalytic site defined by CSA, PubMed 11470436, 10595562

Chain	Residue	Details
D	GLN73

site_id	CSA3
Number of Residues	1
Details	a catalytic site defined by CSA, PubMed 11470436, 10595562

Chain	Residue	Details
F	GLN73

site_id	CSA4
Number of Residues	1
Details	a catalytic site defined by CSA, PubMed 11470436, 10595562

Chain	Residue	Details
H	GLN73

site_id	CSA5
Number of Residues	1
Details	a catalytic site defined by CSA, PubMed 11470436, 10595562

Chain	Residue	Details
A	ASP65

site_id	CSA6
Number of Residues	1
Details	a catalytic site defined by CSA, PubMed 11470436, 10595562

Chain	Residue	Details
C	ASP65

site_id	CSA7
Number of Residues	1
Details	a catalytic site defined by CSA, PubMed 11470436, 10595562

Chain	Residue	Details
E	ASP65

site_id	CSA8
Number of Residues	1
Details	a catalytic site defined by CSA, PubMed 11470436, 10595562

Chain	Residue	Details
G	ASP65

site_id	MCSA1
Number of Residues	5
Details	M-CSA 657

Chain	Residue	Details
B	HIS70	metal ligand
B	GLN73	proton acceptor, proton donor
B	HIS74	hydrogen bond donor, metal ligand
B	GLU143	electrostatic stabiliser, hydrogen bond acceptor
B	GLU150	metal ligand

site_id	MCSA2
Number of Residues	5
Details	M-CSA 657

Chain	Residue	Details
D	HIS70	metal ligand
D	GLN73	proton acceptor, proton donor
D	HIS74	hydrogen bond donor, metal ligand
D	GLU143	electrostatic stabiliser, hydrogen bond acceptor
D	GLU150	metal ligand

site_id	MCSA3
Number of Residues	5
Details	M-CSA 657

Chain	Residue	Details
F	HIS70	metal ligand
F	GLN73	proton acceptor, proton donor
F	HIS74	hydrogen bond donor, metal ligand
F	GLU143	electrostatic stabiliser, hydrogen bond acceptor
F	GLU150	metal ligand

site_id	MCSA4
Number of Residues	5
Details	M-CSA 657

Chain	Residue	Details
H	HIS70	metal ligand
H	GLN73	proton acceptor, proton donor
H	HIS74	hydrogen bond donor, metal ligand
H	GLU143	electrostatic stabiliser, hydrogen bond acceptor
H	GLU150	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)