1HR6
Yeast Mitochondrial Processing Peptidase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006508 | biological_process | proteolysis |
A | 0006627 | biological_process | protein processing involved in protein targeting to mitochondrion |
A | 0017087 | cellular_component | mitochondrial processing peptidase complex |
A | 0046872 | molecular_function | metal ion binding |
A | 0061133 | molecular_function | endopeptidase activator activity |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0006508 | biological_process | proteolysis |
B | 0006627 | biological_process | protein processing involved in protein targeting to mitochondrion |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0017087 | cellular_component | mitochondrial processing peptidase complex |
B | 0046872 | molecular_function | metal ion binding |
C | 0004222 | molecular_function | metalloendopeptidase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005739 | cellular_component | mitochondrion |
C | 0005759 | cellular_component | mitochondrial matrix |
C | 0006508 | biological_process | proteolysis |
C | 0006627 | biological_process | protein processing involved in protein targeting to mitochondrion |
C | 0017087 | cellular_component | mitochondrial processing peptidase complex |
C | 0046872 | molecular_function | metal ion binding |
C | 0061133 | molecular_function | endopeptidase activator activity |
D | 0004222 | molecular_function | metalloendopeptidase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005739 | cellular_component | mitochondrion |
D | 0005759 | cellular_component | mitochondrial matrix |
D | 0006508 | biological_process | proteolysis |
D | 0006627 | biological_process | protein processing involved in protein targeting to mitochondrion |
D | 0008237 | molecular_function | metallopeptidase activity |
D | 0008270 | molecular_function | zinc ion binding |
D | 0017087 | cellular_component | mitochondrial processing peptidase complex |
D | 0046872 | molecular_function | metal ion binding |
E | 0004222 | molecular_function | metalloendopeptidase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005739 | cellular_component | mitochondrion |
E | 0005759 | cellular_component | mitochondrial matrix |
E | 0006508 | biological_process | proteolysis |
E | 0006627 | biological_process | protein processing involved in protein targeting to mitochondrion |
E | 0017087 | cellular_component | mitochondrial processing peptidase complex |
E | 0046872 | molecular_function | metal ion binding |
E | 0061133 | molecular_function | endopeptidase activator activity |
F | 0004222 | molecular_function | metalloendopeptidase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005739 | cellular_component | mitochondrion |
F | 0005759 | cellular_component | mitochondrial matrix |
F | 0006508 | biological_process | proteolysis |
F | 0006627 | biological_process | protein processing involved in protein targeting to mitochondrion |
F | 0008237 | molecular_function | metallopeptidase activity |
F | 0008270 | molecular_function | zinc ion binding |
F | 0017087 | cellular_component | mitochondrial processing peptidase complex |
F | 0046872 | molecular_function | metal ion binding |
G | 0004222 | molecular_function | metalloendopeptidase activity |
G | 0005515 | molecular_function | protein binding |
G | 0005739 | cellular_component | mitochondrion |
G | 0005759 | cellular_component | mitochondrial matrix |
G | 0006508 | biological_process | proteolysis |
G | 0006627 | biological_process | protein processing involved in protein targeting to mitochondrion |
G | 0017087 | cellular_component | mitochondrial processing peptidase complex |
G | 0046872 | molecular_function | metal ion binding |
G | 0061133 | molecular_function | endopeptidase activator activity |
H | 0004222 | molecular_function | metalloendopeptidase activity |
H | 0005515 | molecular_function | protein binding |
H | 0005739 | cellular_component | mitochondrion |
H | 0005759 | cellular_component | mitochondrial matrix |
H | 0006508 | biological_process | proteolysis |
H | 0006627 | biological_process | protein processing involved in protein targeting to mitochondrion |
H | 0008237 | molecular_function | metallopeptidase activity |
H | 0008270 | molecular_function | zinc ion binding |
H | 0017087 | cellular_component | mitochondrial processing peptidase complex |
H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 501 |
Chain | Residue |
B | HIS70 |
B | HIS74 |
B | GLU150 |
B | HOH502 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 502 |
Chain | Residue |
D | HIS70 |
D | HIS74 |
D | GLU150 |
D | HOH503 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN F 503 |
Chain | Residue |
F | HIS74 |
F | GLU150 |
F | HOH504 |
F | HIS70 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN H 504 |
Chain | Residue |
H | HIS70 |
H | HIS74 |
H | GLU150 |
H | HOH505 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EPE A 489 |
Chain | Residue |
A | TRP147 |
A | ARG176 |
E | PRO175 |
E | ARG176 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EPE G 489 |
Chain | Residue |
C | TRP147 |
C | PRO175 |
C | ARG176 |
G | TRP147 |
G | PRO175 |
G | ARG176 |
Functional Information from PROSITE/UniProt
site_id | PS00143 |
Number of Residues | 24 |
Details | INSULINASE Insulinase family, zinc-binding region signature. GsrfegrnlkGcTHILDRLaFkST |
Chain | Residue | Details |
A | GLY49-THR72 | |
B | GLY57-THR80 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:11470436, ECO:0007744|PDB:1HR6 |
Chain | Residue | Details |
B | GLU73 | |
D | GLU73 | |
F | GLU73 | |
H | GLU73 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:11470436, ECO:0000269|PubMed:9654444, ECO:0007744|PDB:1HR6, ECO:0007744|PDB:1HR7, ECO:0007744|PDB:1HR8, ECO:0007744|PDB:1HR9 |
Chain | Residue | Details |
B | HIS70 | |
D | HIS70 | |
F | HIS70 | |
H | HIS70 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:11470436, ECO:0007744|PDB:1HR6, ECO:0007744|PDB:1HR7, ECO:0007744|PDB:1HR8, ECO:0007744|PDB:1HR9 |
Chain | Residue | Details |
B | HIS74 | |
B | GLU150 | |
D | HIS74 | |
D | GLU150 | |
F | HIS74 | |
F | GLU150 | |
H | HIS74 | |
H | GLU150 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956 |
Chain | Residue | Details |
B | SER243 | |
D | SER243 | |
F | SER243 | |
H | SER243 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | a catalytic site defined by CSA, PubMed Matthews1988, 11470436, 6525336, 1570301, 7490252 |
Chain | Residue | Details |
B | GLU73 |
site_id | CSA2 |
Number of Residues | 1 |
Details | a catalytic site defined by CSA, PubMed Matthews1988, 11470436, 6525336, 1570301, 7490252 |
Chain | Residue | Details |
D | GLU73 |
site_id | CSA3 |
Number of Residues | 1 |
Details | a catalytic site defined by CSA, PubMed Matthews1988, 11470436, 6525336, 1570301, 7490252 |
Chain | Residue | Details |
F | GLU73 |
site_id | CSA4 |
Number of Residues | 1 |
Details | a catalytic site defined by CSA, PubMed Matthews1988, 11470436, 6525336, 1570301, 7490252 |
Chain | Residue | Details |
H | GLU73 |
site_id | CSA5 |
Number of Residues | 1 |
Details | a catalytic site defined by CSA, PubMed Matthews1988, 11470436, 6525336, 1570301, 7490252 |
Chain | Residue | Details |
A | ASP65 |
site_id | CSA6 |
Number of Residues | 1 |
Details | a catalytic site defined by CSA, PubMed Matthews1988, 11470436, 6525336, 1570301, 7490252 |
Chain | Residue | Details |
C | ASP65 |
site_id | CSA7 |
Number of Residues | 1 |
Details | a catalytic site defined by CSA, PubMed Matthews1988, 11470436, 6525336, 1570301, 7490252 |
Chain | Residue | Details |
E | ASP65 |
site_id | CSA8 |
Number of Residues | 1 |
Details | a catalytic site defined by CSA, PubMed Matthews1988, 11470436, 6525336, 1570301, 7490252 |
Chain | Residue | Details |
G | ASP65 |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 657 |
Chain | Residue | Details |
B | HIS70 | metal ligand |
B | GLU73 | proton acceptor, proton donor |
B | HIS74 | hydrogen bond donor, metal ligand |
B | GLU143 | electrostatic stabiliser, hydrogen bond acceptor |
B | GLU150 | metal ligand |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 657 |
Chain | Residue | Details |
D | HIS70 | metal ligand |
D | GLU73 | proton acceptor, proton donor |
D | HIS74 | hydrogen bond donor, metal ligand |
D | GLU143 | electrostatic stabiliser, hydrogen bond acceptor |
D | GLU150 | metal ligand |
site_id | MCSA3 |
Number of Residues | 5 |
Details | M-CSA 657 |
Chain | Residue | Details |
F | HIS70 | metal ligand |
F | GLU73 | proton acceptor, proton donor |
F | HIS74 | hydrogen bond donor, metal ligand |
F | GLU143 | electrostatic stabiliser, hydrogen bond acceptor |
F | GLU150 | metal ligand |
site_id | MCSA4 |
Number of Residues | 5 |
Details | M-CSA 657 |
Chain | Residue | Details |
H | HIS70 | metal ligand |
H | GLU73 | proton acceptor, proton donor |
H | HIS74 | hydrogen bond donor, metal ligand |
H | GLU143 | electrostatic stabiliser, hydrogen bond acceptor |
H | GLU150 | metal ligand |