Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006097 | biological_process | glyoxylate cycle |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0006097 | biological_process | glyoxylate cycle |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CIT A 425 |
| Chain | Residue |
| A | THR96 |
| A | HOH1501 |
| B | LYS221 |
| B | ASN223 |
| B | ILE224 |
| A | SER104 |
| A | ASN106 |
| A | ARG110 |
| A | ARG144 |
| A | TYR151 |
| A | THR344 |
| A | HIS345 |
| A | HOH1438 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CIT B 825 |
| Chain | Residue |
| A | LYS221 |
| A | ASN223 |
| A | ILE224 |
| A | PGR907 |
| B | THR96 |
| B | SER104 |
| B | ASN106 |
| B | ARG110 |
| B | ARG144 |
| B | TYR151 |
| B | ASP311 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGO A 901 |
| Chain | Residue |
| A | PRO121 |
| A | VAL122 |
| A | ARG123 |
| A | PHE125 |
| A | VAL321 |
| A | ILE326 |
| A | PRO328 |
| A | PGO902 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGO A 902 |
| Chain | Residue |
| A | ARG123 |
| A | PGO901 |
| A | HOH1369 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGO B 903 |
| Chain | Residue |
| A | HOH1105 |
| B | ARG134 |
| B | ASP137 |
| B | THR295 |
| B | HOH1592 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGO B 904 |
| Chain | Residue |
| B | TRP251 |
| B | TYR254 |
| B | GLN270 |
| B | HOH1463 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGO B 905 |
| Chain | Residue |
| B | PRO121 |
| B | ARG123 |
| B | HOH1338 |
| B | HOH1489 |
| B | HOH1579 |
| B | HOH1589 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 906 |
| Chain | Residue |
| A | TYR237 |
| A | TRP251 |
| A | ALA252 |
| A | ASP255 |
| A | ASP283 |
| A | HOH1215 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR A 907 |
| Chain | Residue |
| A | LYS221 |
| A | ASN223 |
| A | ILE285 |
| A | ASP287 |
| A | ILE288 |
| B | CIT825 |
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLNGDYiSDalAaqv.GGIGI |
| Chain | Residue | Details |
| A | ASN307-ILE326 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | THR95 | |
| B | ASP311 | |
| B | HIS345 | |
| B | ASN358 | |
| B | TYR397 | |
| B | ARG401 | |
| A | ARG120 | |
| A | ASP311 | |
| A | HIS345 | |
| A | ASN358 | |
| A | TYR397 | |
| A | ARG401 | |
| B | THR95 | |
| B | ARG120 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | THR96 | |
| B | ARG144 | |
| A | SER104 | |
| A | ASN106 | |
| A | ARG110 | |
| A | ARG144 | |
| B | THR96 | |
| B | SER104 | |
| B | ASN106 | |
| B | ARG110 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Critical for catalysis => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR151 | |
| A | LYS221 | |
| B | TYR151 | |
| B | LYS221 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| A | LYS221 | |
| A | ASP287 | |
| B | TYR151 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| A | TYR151 | |
| B | LYS221 | |
| B | ASP287 | |
