Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
A | 0005515 | molecular_function | protein binding |
A | 0006097 | biological_process | glyoxylate cycle |
A | 0006099 | biological_process | tricarboxylic acid cycle |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0046872 | molecular_function | metal ion binding |
A | 0051287 | molecular_function | NAD binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004450 | molecular_function | isocitrate dehydrogenase (NADP+) activity |
B | 0005515 | molecular_function | protein binding |
B | 0006097 | biological_process | glyoxylate cycle |
B | 0006099 | biological_process | tricarboxylic acid cycle |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0046872 | molecular_function | metal ion binding |
B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CIT A 425 |
Chain | Residue |
A | THR96 |
A | HOH1501 |
B | LYS221 |
B | ASN223 |
B | ILE224 |
A | SER104 |
A | ASN106 |
A | ARG110 |
A | ARG144 |
A | TYR151 |
A | THR344 |
A | HIS345 |
A | HOH1438 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE CIT B 825 |
Chain | Residue |
A | LYS221 |
A | ASN223 |
A | ILE224 |
A | PGR907 |
B | THR96 |
B | SER104 |
B | ASN106 |
B | ARG110 |
B | ARG144 |
B | TYR151 |
B | ASP311 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PGO A 901 |
Chain | Residue |
A | PRO121 |
A | VAL122 |
A | ARG123 |
A | PHE125 |
A | VAL321 |
A | ILE326 |
A | PRO328 |
A | PGO902 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PGO A 902 |
Chain | Residue |
A | ARG123 |
A | PGO901 |
A | HOH1369 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PGO B 903 |
Chain | Residue |
A | HOH1105 |
B | ARG134 |
B | ASP137 |
B | THR295 |
B | HOH1592 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PGO B 904 |
Chain | Residue |
B | TRP251 |
B | TYR254 |
B | GLN270 |
B | HOH1463 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PGO B 905 |
Chain | Residue |
B | PRO121 |
B | ARG123 |
B | HOH1338 |
B | HOH1489 |
B | HOH1579 |
B | HOH1589 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PGR A 906 |
Chain | Residue |
A | TYR237 |
A | TRP251 |
A | ALA252 |
A | ASP255 |
A | ASP283 |
A | HOH1215 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PGR A 907 |
Chain | Residue |
A | LYS221 |
A | ASN223 |
A | ILE285 |
A | ASP287 |
A | ILE288 |
B | CIT825 |
Functional Information from PROSITE/UniProt
site_id | PS00470 |
Number of Residues | 20 |
Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLNGDYiSDalAaqv.GGIGI |
Chain | Residue | Details |
A | ASN307-ILE326 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | THR95 | |
B | ASP311 | |
B | HIS345 | |
B | ASN358 | |
B | TYR397 | |
B | ARG401 | |
A | ARG120 | |
A | ASP311 | |
A | HIS345 | |
A | ASN358 | |
A | TYR397 | |
A | ARG401 | |
B | THR95 | |
B | ARG120 | |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
A | THR96 | |
B | ARG144 | |
A | SER104 | |
A | ASN106 | |
A | ARG110 | |
A | ARG144 | |
B | THR96 | |
B | SER104 | |
B | ASN106 | |
B | ARG110 | |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | SITE: Critical for catalysis => ECO:0000250 |
Chain | Residue | Details |
A | TYR151 | |
A | LYS221 | |
B | TYR151 | |
B | LYS221 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
A | LYS221 | |
A | ASP287 | |
B | TYR151 | |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
A | TYR151 | |
B | LYS221 | |
B | ASP287 | |