1HQG

CRYSTAL STRUCTURE OF THE H141C ARGINASE VARIANT COMPLEXED WITH PRODUCTS ORNITHINE AND UREA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000050	biological_process	urea cycle
A	0001889	biological_process	liver development
A	0001938	biological_process	positive regulation of endothelial cell proliferation
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0004053	molecular_function	arginase activity
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006525	biological_process	arginine metabolic process
A	0007565	biological_process	female pregnancy
A	0009410	biological_process	response to xenobiotic stimulus
A	0009624	biological_process	response to nematode
A	0009635	biological_process	response to herbicide
A	0010042	biological_process	response to manganese ion
A	0010043	biological_process	response to zinc ion
A	0010269	biological_process	response to selenium ion
A	0014075	biological_process	response to amine
A	0016787	molecular_function	hydrolase activity
A	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
A	0030145	molecular_function	manganese ion binding
A	0030324	biological_process	lung development
A	0032496	biological_process	response to lipopolysaccharide
A	0032964	biological_process	collagen biosynthetic process
A	0033189	biological_process	response to vitamin A
A	0033197	biological_process	response to vitamin E
A	0042127	biological_process	regulation of cell population proliferation
A	0042130	biological_process	negative regulation of T cell proliferation
A	0042802	molecular_function	identical protein binding
A	0042832	biological_process	defense response to protozoan
A	0043025	cellular_component	neuronal cell body
A	0043200	biological_process	response to amino acid
A	0043434	biological_process	response to peptide hormone
A	0045087	biological_process	innate immune response
A	0046007	biological_process	negative regulation of activated T cell proliferation
A	0046686	biological_process	response to cadmium ion
A	0046872	molecular_function	metal ion binding
A	0048545	biological_process	response to steroid hormone
A	0048678	biological_process	response to axon injury
A	0051597	biological_process	response to methylmercury
A	0060056	biological_process	mammary gland involution
A	0060135	biological_process	maternal process involved in female pregnancy
A	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071353	biological_process	cellular response to interleukin-4
A	0071377	biological_process	cellular response to glucagon stimulus
A	0071549	biological_process	cellular response to dexamethasone stimulus
A	0071560	biological_process	cellular response to transforming growth factor beta stimulus
A	1905541	biological_process	regulation of L-arginine import across plasma membrane
A	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
B	0000050	biological_process	urea cycle
B	0001889	biological_process	liver development
B	0001938	biological_process	positive regulation of endothelial cell proliferation
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0004053	molecular_function	arginase activity
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006525	biological_process	arginine metabolic process
B	0007565	biological_process	female pregnancy
B	0009410	biological_process	response to xenobiotic stimulus
B	0009624	biological_process	response to nematode
B	0009635	biological_process	response to herbicide
B	0010042	biological_process	response to manganese ion
B	0010043	biological_process	response to zinc ion
B	0010269	biological_process	response to selenium ion
B	0014075	biological_process	response to amine
B	0016787	molecular_function	hydrolase activity
B	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
B	0030145	molecular_function	manganese ion binding
B	0030324	biological_process	lung development
B	0032496	biological_process	response to lipopolysaccharide
B	0032964	biological_process	collagen biosynthetic process
B	0033189	biological_process	response to vitamin A
B	0033197	biological_process	response to vitamin E
B	0042127	biological_process	regulation of cell population proliferation
B	0042130	biological_process	negative regulation of T cell proliferation
B	0042802	molecular_function	identical protein binding
B	0042832	biological_process	defense response to protozoan
B	0043025	cellular_component	neuronal cell body
B	0043200	biological_process	response to amino acid
B	0043434	biological_process	response to peptide hormone
B	0045087	biological_process	innate immune response
B	0046007	biological_process	negative regulation of activated T cell proliferation
B	0046686	biological_process	response to cadmium ion
B	0046872	molecular_function	metal ion binding
B	0048545	biological_process	response to steroid hormone
B	0048678	biological_process	response to axon injury
B	0051597	biological_process	response to methylmercury
B	0060056	biological_process	mammary gland involution
B	0060135	biological_process	maternal process involved in female pregnancy
B	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
B	0071222	biological_process	cellular response to lipopolysaccharide
B	0071353	biological_process	cellular response to interleukin-4
B	0071377	biological_process	cellular response to glucagon stimulus
B	0071549	biological_process	cellular response to dexamethasone stimulus
B	0071560	biological_process	cellular response to transforming growth factor beta stimulus
B	1905541	biological_process	regulation of L-arginine import across plasma membrane
B	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
C	0000050	biological_process	urea cycle
C	0001889	biological_process	liver development
C	0001938	biological_process	positive regulation of endothelial cell proliferation
C	0002250	biological_process	adaptive immune response
C	0002376	biological_process	immune system process
C	0004053	molecular_function	arginase activity
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006525	biological_process	arginine metabolic process
C	0007565	biological_process	female pregnancy
C	0009410	biological_process	response to xenobiotic stimulus
C	0009624	biological_process	response to nematode
C	0009635	biological_process	response to herbicide
C	0010042	biological_process	response to manganese ion
C	0010043	biological_process	response to zinc ion
C	0010269	biological_process	response to selenium ion
C	0014075	biological_process	response to amine
C	0016787	molecular_function	hydrolase activity
C	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
C	0030145	molecular_function	manganese ion binding
C	0030324	biological_process	lung development
C	0032496	biological_process	response to lipopolysaccharide
C	0032964	biological_process	collagen biosynthetic process
C	0033189	biological_process	response to vitamin A
C	0033197	biological_process	response to vitamin E
C	0042127	biological_process	regulation of cell population proliferation
C	0042130	biological_process	negative regulation of T cell proliferation
C	0042802	molecular_function	identical protein binding
C	0042832	biological_process	defense response to protozoan
C	0043025	cellular_component	neuronal cell body
C	0043200	biological_process	response to amino acid
C	0043434	biological_process	response to peptide hormone
C	0045087	biological_process	innate immune response
C	0046007	biological_process	negative regulation of activated T cell proliferation
C	0046686	biological_process	response to cadmium ion
C	0046872	molecular_function	metal ion binding
C	0048545	biological_process	response to steroid hormone
C	0048678	biological_process	response to axon injury
C	0051597	biological_process	response to methylmercury
C	0060056	biological_process	mammary gland involution
C	0060135	biological_process	maternal process involved in female pregnancy
C	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0071353	biological_process	cellular response to interleukin-4
C	0071377	biological_process	cellular response to glucagon stimulus
C	0071549	biological_process	cellular response to dexamethasone stimulus
C	0071560	biological_process	cellular response to transforming growth factor beta stimulus
C	1905541	biological_process	regulation of L-arginine import across plasma membrane
C	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 500

Chain	Residue
A	HIS101
A	ASP124
A	ASP128
A	ASP232
A	MN501
A	HOH604
A	URE1901

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 501

Chain	Residue
A	ASP232
A	ASP234
A	MN500
A	HOH604
A	URE1901
A	ASP124
A	HIS126

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN B 502

Chain	Residue
B	HIS101
B	ASP124
B	ASP128
B	ASP232
B	MN503
B	HOH660
B	URE1902

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN B 503

Chain	Residue
B	ASP124
B	HIS126
B	ASP232
B	ASP234
B	MN502
B	HOH660
B	URE1902

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN C 504

Chain	Residue
C	HIS101
C	ASP124
C	ASP128
C	ASP232
C	MN505
C	HOH714
C	URE1903

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN C 505

Chain	Residue
C	ASP124
C	HIS126
C	ASP232
C	ASP234
C	MN504
C	HOH714
C	URE1903

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ORN A 801

Chain	Residue
A	HIS126
A	ASP128
A	ASN130
A	SER137
A	CME141
A	ASP183
A	GLU186
A	HOH604
A	HOH641
A	HOH642
A	URE1901

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ORN B 902

Chain	Residue
B	HIS126
B	ASP128
B	ASN130
B	SER137
B	CME141
B	ASP183
B	GLU186
B	HOH660
B	HOH696
B	HOH697
B	URE1902

---

site_id	AC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ORN C 903

Chain	Residue
C	HIS126
C	ASP128
C	ASN130
C	SER137
C	CME141
C	ASP183
C	GLU186
C	HOH714
C	HOH752
C	HOH753
C	URE1903

---

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE URE A 1901

Chain	Residue
A	HIS101
A	ASP128
A	CME141
A	ASP232
A	ASP234
A	GLU277
A	MN500
A	MN501
A	HOH604
A	HOH644
A	ORN801

---

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE URE B 1902

Chain	Residue
B	HIS101
B	ASP128
B	CME141
B	ASP232
B	ASP234
B	GLU277
B	MN502
B	MN503
B	HOH660
B	HOH699
B	ORN902

---

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE URE C 1903

Chain	Residue
C	CME141
C	ASP232
C	ASP234
C	GLU277
C	MN504
C	MN505
C	HOH714
C	HOH755
C	ORN903
C	HIS101
C	ASP128

---

Functional Information from PROSITE/UniProt

site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SFDVDgldPvftPAtgtpvvgG

Chain	Residue	Details
A	SER230-GLY251

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10542097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12820884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15315440","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16266687","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8849731","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TA1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZPE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E8Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E9B","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10542097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12820884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15315440","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16266687","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8849731","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9265637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TA1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZPE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E8Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5RLA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PDB","id":"1HQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10542097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12820884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15315440","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16266687","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8849731","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9265637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TA1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZPE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E8Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RLA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PDB","id":"1HQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PDB","id":"1T5G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10542097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12820884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15315440","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16266687","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8849731","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9265637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TA1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZPE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E8Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5RLA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10542097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12820884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15315440","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16266687","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8849731","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9265637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P8S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T4T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TA1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZPE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E8Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RLA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5RLA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P53608","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P78540","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q61176","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q61176","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P05089","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1cev

Chain	Residue	Details
A	GLU277
A	ASP128

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1cev

Chain	Residue	Details
B	GLU277
B	ASP128

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1cev

Chain	Residue	Details
C	GLU277
C	ASP128

---