1HQD

PSEUDOMONAS CEPACIA LIPASE COMPLEXED WITH TRANSITION STATE ANALOGUE OF 1-PHENOXY-2-ACETOXY BUTANE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004806	molecular_function	triacylglycerol lipase activity
A	0005576	cellular_component	extracellular region
A	0006629	biological_process	lipid metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 613

Chain	Residue
A	ASP242
A	ASP288
A	GLN292
A	LEU293
A	VAL296
A	HOH326
A	HOH409

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE INK A 612

Chain	Residue
A	TYR29
A	SER87
A	GLN88
A	PHE119
A	LEU167
A	HIS286
A	GLY16
A	LEU17

---

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VNLVGHSQGG

Chain	Residue	Details
A	VAL81-GLY90

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	212
Details	Domain: {"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15850979","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18386861","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032073","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032074","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1HQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032073","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9032074","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15850979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18386861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11453990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15850979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18386861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9032073","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9032074","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9660188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1tah

Chain	Residue	Details
A	ASP264
A	HIS286
A	SER87

---

site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 1tah

Chain	Residue	Details
A	ASP264
A	HIS286
A	LEU17
A	GLN88
A	SER87

---