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1HQA

ALKALINE PHOSPHATASE (H412Q)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004035molecular_functionalkaline phosphatase activity
A0004721molecular_functionphosphoprotein phosphatase activity
A0005515molecular_functionprotein binding
A0006470biological_processprotein dephosphorylation
A0008270molecular_functionzinc ion binding
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030288cellular_componentouter membrane-bounded periplasmic space
A0030613molecular_functionoxidoreductase activity, acting on phosphorus or arsenic in donors
A0033748molecular_functionhydrogenase (acceptor) activity
A0042597cellular_componentperiplasmic space
A0046872molecular_functionmetal ion binding
B0000287molecular_functionmagnesium ion binding
B0004035molecular_functionalkaline phosphatase activity
B0004721molecular_functionphosphoprotein phosphatase activity
B0005515molecular_functionprotein binding
B0006470biological_processprotein dephosphorylation
B0008270molecular_functionzinc ion binding
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030288cellular_componentouter membrane-bounded periplasmic space
B0030613molecular_functionoxidoreductase activity, acting on phosphorus or arsenic in donors
B0033748molecular_functionhydrogenase (acceptor) activity
B0042597cellular_componentperiplasmic space
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idA
Number of Residues13
Details
ChainResidue
AASP327
ATHR155
AGLU322
AARG166
ASER102
AHIS331
AGLN412
AZN450
AZN451
AZN452
AASP51
AASP369
AHIS370

site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 450
ChainResidue
AASP327
AHIS331
AGLN412
AHOH646

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 451
ChainResidue
AASP51
ASER102
AASP369
AHIS370

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ZN A 452
ChainResidue
AASP51
AASP153
ATHR155
AGLU322
AHOH453
AHOH454
AHOH455

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN B 450
ChainResidue
BASP327
BHIS331
BGLN412
BHOH597
BHOH600

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN B 451
ChainResidue
BASP51
BSER102
BASP327
BASP369
BHIS370

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ZN B 452
ChainResidue
BASP51
BASP153
BTHR155
BGLU322
BHOH508
BHOH509
BHOH510

site_idB
Number of Residues13
Details
ChainResidue
BASP327
BHIS331
BGLN412
BZN450
BZN451
BZN452
BASP51
BASP369
BHIS370
BTHR155
BGLU322
BARG166
BSER102

Functional Information from PROSITE/UniProt
site_idPS00123
Number of Residues9
DetailsALKALINE_PHOSPHATASE Alkaline phosphatase active site. VtDSAASAT
ChainResidueDetails
AVAL99-THR107

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Phosphoserine intermediate
ChainResidueDetails
ASER102
BSER102

site_idSWS_FT_FI2
Number of Residues18
DetailsBINDING:
ChainResidueDetails
AASP51
BASP51
BASP153
BTHR155
BGLU322
BASP327
BHIS331
BASP369
BHIS370
BGLN412
AASP153
ATHR155
AGLU322
AASP327
AHIS331
AASP369
AHIS370
AGLN412

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1alk
ChainResidueDetails
ASER102
AARG166

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1alk
ChainResidueDetails
BSER102
BARG166

site_idMCSA1
Number of Residues12
DetailsM-CSA 44
ChainResidueDetails
AASP51metal ligand
AASP369metal ligand
AHIS370metal ligand
AGLN412metal ligand
ASER102hydrogen bond acceptor, hydrogen bond donor, metal ligand, nucleofuge, nucleophile, proton acceptor, proton donor
AASP153metal ligand
ATHR155metal ligand
AARG166activator, electrostatic stabiliser, hydrogen bond donor
AGLU322metal ligand
AASP327metal ligand
ALYS328metal ligand
AHIS331metal ligand

site_idMCSA2
Number of Residues12
DetailsM-CSA 44
ChainResidueDetails
BASP51metal ligand
BASP369metal ligand
BHIS370metal ligand
BGLN412metal ligand
BSER102hydrogen bond acceptor, hydrogen bond donor, metal ligand, nucleofuge, nucleophile, proton acceptor, proton donor
BASP153metal ligand
BTHR155metal ligand
BARG166activator, electrostatic stabiliser, hydrogen bond donor
BGLU322metal ligand
BASP327metal ligand
BLYS328metal ligand
BHIS331metal ligand

226707

PDB entries from 2024-10-30

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