1HQ6
STRUCTURE OF PYRUVOYL-DEPENDENT HISTIDINE DECARBOXYLASE AT PH 8
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004398 | molecular_function | histidine decarboxylase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006547 | biological_process | L-histidine metabolic process |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0004398 | molecular_function | histidine decarboxylase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006547 | biological_process | L-histidine metabolic process |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0004398 | molecular_function | histidine decarboxylase activity |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006547 | biological_process | L-histidine metabolic process |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0004398 | molecular_function | histidine decarboxylase activity |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006547 | biological_process | L-histidine metabolic process |
| D | 0016831 | molecular_function | carboxy-lyase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor |
| Chain | Residue | Details |
| B | GLU197 | |
| D | GLU197 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | PYR82 | |
| D | PYR82 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Cleavage (non-hydrolytic) |
| Chain | Residue | Details |
| B | PYR82 | |
| D | PYR82 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Pyruvic acid (Ser) => ECO:0000269|PubMed:6698997 |
| Chain | Residue | Details |
| B | PHE83 | |
| D | PHE83 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1pya |
| Chain | Residue | Details |
| A | SER81 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1pya |
| Chain | Residue | Details |
| C | SER81 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1pya |
| Chain | Residue | Details |
| D | PHE195 | |
| D | GLU197 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1pya |
| Chain | Residue | Details |
| B | PHE195 | |
| B | GLU197 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 49 |
| Chain | Residue | Details |
| B | ALA199 | electrostatic stabiliser, hydrogen bond donor |
| B | VAL201 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 49 |
| Chain | Residue | Details |
| D | ALA199 | electrostatic stabiliser, hydrogen bond donor |
| D | VAL201 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
