1HP2

SOLUTION STRUCTURE OF A TOXIN FROM THE SCORPION TITYUS SERRULATUS (TSTX-K ALPHA) DETERMINED BY NMR.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008200	molecular_function	ion channel inhibitor activity
A	0015459	molecular_function	potassium channel regulator activity
A	0019870	molecular_function	potassium channel inhibitor activity
A	0035738	biological_process	venom-mediated perturbation of biological process
A	0090729	molecular_function	toxin activity
A	0099106	molecular_function	ion channel regulator activity

Functional Information from PROSITE/UniProt

site_id	PS01138
Number of Residues	23
Details	SCORP_SHORT_TOXIN Scorpion short toxins signature. ClpkCkeaigkaa.GKCMngkCkC

Chain	Residue	Details
A	CYS13-CYS35

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Peptide: {"description":"Potassium channel toxin alpha-KTx 4.1","featureId":"PRO_0000044923","evidences":[{"source":"PubMed","id":"7509073","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"Interaction with Ca(2+)-activated K(+) channels","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Basic residue of the functional dyad","evidences":[{"source":"UniProtKB","id":"O46028","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Aromatic residue of the functional dyad","evidences":[{"source":"UniProtKB","id":"O46028","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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