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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1HNC

CRYSTAL STRUCTURE OF HUMAN CLASS MU GLUTATHIONE TRANSFERASE GSTM2-2: EFFECTS OF LATTICE PACKING ON CONFORMATIONAL HETEROGENEITY

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0004602molecular_functionglutathione peroxidase activity
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006749biological_processglutathione metabolic process
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A0016529cellular_componentsarcoplasmic reticulum
A0016740molecular_functiontransferase activity
A0018916biological_processnitrobenzene metabolic process
A0019855molecular_functioncalcium channel inhibitor activity
A0019899molecular_functionenzyme binding
A0042178biological_processxenobiotic catabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043295molecular_functionglutathione binding
A0043651biological_processlinoleic acid metabolic process
A0044325molecular_functiontransmembrane transporter binding
A0051122biological_processhepoxilin biosynthetic process
A0055119biological_processrelaxation of cardiac muscle
A0070062cellular_componentextracellular exosome
A0070458biological_processcellular detoxification of nitrogen compound
A0071313biological_processcellular response to caffeine
A0098869biological_processcellular oxidant detoxification
B0004364molecular_functionglutathione transferase activity
B0004602molecular_functionglutathione peroxidase activity
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006749biological_processglutathione metabolic process
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
B0016529cellular_componentsarcoplasmic reticulum
B0016740molecular_functiontransferase activity
B0018916biological_processnitrobenzene metabolic process
B0019855molecular_functioncalcium channel inhibitor activity
B0019899molecular_functionenzyme binding
B0042178biological_processxenobiotic catabolic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043295molecular_functionglutathione binding
B0043651biological_processlinoleic acid metabolic process
B0044325molecular_functiontransmembrane transporter binding
B0051122biological_processhepoxilin biosynthetic process
B0055119biological_processrelaxation of cardiac muscle
B0070062cellular_componentextracellular exosome
B0070458biological_processcellular detoxification of nitrogen compound
B0071313biological_processcellular response to caffeine
B0098869biological_processcellular oxidant detoxification
C0004364molecular_functionglutathione transferase activity
C0004602molecular_functionglutathione peroxidase activity
C0005504molecular_functionfatty acid binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006749biological_processglutathione metabolic process
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C0016529cellular_componentsarcoplasmic reticulum
C0016740molecular_functiontransferase activity
C0018916biological_processnitrobenzene metabolic process
C0019855molecular_functioncalcium channel inhibitor activity
C0019899molecular_functionenzyme binding
C0042178biological_processxenobiotic catabolic process
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043295molecular_functionglutathione binding
C0043651biological_processlinoleic acid metabolic process
C0044325molecular_functiontransmembrane transporter binding
C0051122biological_processhepoxilin biosynthetic process
C0055119biological_processrelaxation of cardiac muscle
C0070062cellular_componentextracellular exosome
C0070458biological_processcellular detoxification of nitrogen compound
C0071313biological_processcellular response to caffeine
C0098869biological_processcellular oxidant detoxification
D0004364molecular_functionglutathione transferase activity
D0004602molecular_functionglutathione peroxidase activity
D0005504molecular_functionfatty acid binding
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0006749biological_processglutathione metabolic process
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
D0016529cellular_componentsarcoplasmic reticulum
D0016740molecular_functiontransferase activity
D0018916biological_processnitrobenzene metabolic process
D0019855molecular_functioncalcium channel inhibitor activity
D0019899molecular_functionenzyme binding
D0042178biological_processxenobiotic catabolic process
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043295molecular_functionglutathione binding
D0043651biological_processlinoleic acid metabolic process
D0044325molecular_functiontransmembrane transporter binding
D0051122biological_processhepoxilin biosynthetic process
D0055119biological_processrelaxation of cardiac muscle
D0070062cellular_componentextracellular exosome
D0070458biological_processcellular detoxification of nitrogen compound
D0071313biological_processcellular response to caffeine
D0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GDN A 218
ChainResidue
ATYR6
AMET211
BASP105
ATRP7
ALEU12
ATRP45
AASN58
ALEU59
APRO60
AGLN71
ASER72
site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GDN B 218
ChainResidue
AASP105
BTYR6
BTRP7
BLEU12
BTRP45
BASN58
BLEU59
BGLN71
BSER72
BMET104
BTYR115
site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GDN C 218
ChainResidue
CTRP7
CLEU12
CARG42
CTRP45
CLYS49
CASN58
CLEU59
CGLN71
CSER72
CMET211
DASP105
site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GDN D 218
ChainResidue
CASP105
DTYR6
DTRP7
DLEU12
DTRP45
DLYS49
DASN58
DLEU59
DGLN71
DSER72
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues344
DetailsDomain: {"description":"GST N-terminal"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues472
DetailsDomain: {"description":"GST C-terminal"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16549767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19808963","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P08010","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsSite: {"description":"Important for substrate specificity"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08010","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
ATYR6
site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
BTYR6
site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
CTYR6
site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
DTYR6

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PDB entries from 2025-07-23

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