1HNA

CRYSTAL STRUCTURE OF HUMAN CLASS MU GLUTATHIONE TRANSFERASE GSTM2-2: EFFECTS OF LATTICE PACKING ON CONFORMATIONAL HETEROGENEITY

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005102	molecular_function	signaling receptor binding
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A	0016529	cellular_component	sarcoplasmic reticulum
A	0016740	molecular_function	transferase activity
A	0018916	biological_process	nitrobenzene metabolic process
A	0019899	molecular_function	enzyme binding
A	0042178	biological_process	xenobiotic catabolic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043295	molecular_function	glutathione binding
A	0043651	biological_process	linoleic acid metabolic process
A	0045171	cellular_component	intercellular bridge
A	0051122	biological_process	hepoxilin biosynthetic process
A	0055119	biological_process	relaxation of cardiac muscle
A	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
A	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
A	0070062	cellular_component	extracellular exosome
A	0070458	biological_process	cellular detoxification of nitrogen compound
A	0071313	biological_process	cellular response to caffeine
A	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GDN A 218

Chain	Residue
A	TYR6
A	ASP105
A	HOH260
A	HOH266
A	HOH291
A	TRP7
A	LEU12
A	TRP45
A	LYS49
A	ASN58
A	LEU59
A	GLN71
A	SER72

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16549767, ECO:0000269|PubMed:19808963

Chain	Residue	Details
A	SER43
A	LEU59
A	SER72
A	TRP7

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P08010

Chain	Residue	Details
A	PHE50

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP116

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Important for substrate specificity

Chain	Residue	Details
A	LYS210

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08010

Chain	Residue	Details
A	TYR27
A	GLN44

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