1HMP
THE CRYSTAL STRUCTURE OF HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH BOUND GMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0001913 | biological_process | T cell mediated cytotoxicity |
A | 0001975 | biological_process | response to amphetamine |
A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006164 | biological_process | purine nucleotide biosynthetic process |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0006178 | biological_process | guanine salvage |
A | 0007625 | biological_process | grooming behavior |
A | 0007626 | biological_process | locomotory behavior |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0021756 | biological_process | striatum development |
A | 0021895 | biological_process | cerebral cortex neuron differentiation |
A | 0021954 | biological_process | central nervous system neuron development |
A | 0032263 | biological_process | GMP salvage |
A | 0032264 | biological_process | IMP salvage |
A | 0042417 | biological_process | dopamine metabolic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0043103 | biological_process | hypoxanthine salvage |
A | 0044209 | biological_process | AMP salvage |
A | 0045964 | biological_process | positive regulation of dopamine metabolic process |
A | 0046038 | biological_process | GMP catabolic process |
A | 0046040 | biological_process | IMP metabolic process |
A | 0046083 | biological_process | adenine metabolic process |
A | 0046100 | biological_process | hypoxanthine metabolic process |
A | 0046651 | biological_process | lymphocyte proliferation |
A | 0046872 | molecular_function | metal ion binding |
A | 0048813 | biological_process | dendrite morphogenesis |
A | 0051289 | biological_process | protein homotetramerization |
A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
A | 0070062 | cellular_component | extracellular exosome |
A | 0071542 | biological_process | dopaminergic neuron differentiation |
B | 0000166 | molecular_function | nucleotide binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0001913 | biological_process | T cell mediated cytotoxicity |
B | 0001975 | biological_process | response to amphetamine |
B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006164 | biological_process | purine nucleotide biosynthetic process |
B | 0006166 | biological_process | purine ribonucleoside salvage |
B | 0006178 | biological_process | guanine salvage |
B | 0007625 | biological_process | grooming behavior |
B | 0007626 | biological_process | locomotory behavior |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0021756 | biological_process | striatum development |
B | 0021895 | biological_process | cerebral cortex neuron differentiation |
B | 0021954 | biological_process | central nervous system neuron development |
B | 0032263 | biological_process | GMP salvage |
B | 0032264 | biological_process | IMP salvage |
B | 0042417 | biological_process | dopamine metabolic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0043103 | biological_process | hypoxanthine salvage |
B | 0044209 | biological_process | AMP salvage |
B | 0045964 | biological_process | positive regulation of dopamine metabolic process |
B | 0046038 | biological_process | GMP catabolic process |
B | 0046040 | biological_process | IMP metabolic process |
B | 0046083 | biological_process | adenine metabolic process |
B | 0046100 | biological_process | hypoxanthine metabolic process |
B | 0046651 | biological_process | lymphocyte proliferation |
B | 0046872 | molecular_function | metal ion binding |
B | 0048813 | biological_process | dendrite morphogenesis |
B | 0051289 | biological_process | protein homotetramerization |
B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
B | 0070062 | cellular_component | extracellular exosome |
B | 0071542 | biological_process | dopaminergic neuron differentiation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE 5GP A 300 |
Chain | Residue |
A | LYS68 |
A | LYS165 |
A | LYS185 |
A | PHE186 |
A | VAL187 |
A | LEU192 |
A | ASP193 |
A | HOH843 |
A | HOH893 |
A | GLU133 |
A | ASP134 |
A | ILE135 |
A | ASP137 |
A | THR138 |
A | GLY139 |
A | LYS140 |
A | THR141 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 5GP B 800 |
Chain | Residue |
B | LYS68 |
B | GLU133 |
B | ILE135 |
B | ASP137 |
B | THR138 |
B | GLY139 |
B | THR141 |
B | LYS165 |
B | LYS185 |
B | PHE186 |
B | VAL187 |
B | ASP193 |
B | HOH851 |
B | HOH876 |
Functional Information from PROSITE/UniProt
site_id | PS00103 |
Number of Residues | 13 |
Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIIDTGkT |
Chain | Residue | Details |
A | VAL129-THR141 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000305 |
Chain | Residue | Details |
A | THR138 | |
B | THR138 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8044844 |
Chain | Residue | Details |
A | GLY69 | |
A | ASP134 | |
A | ARG166 | |
A | PHE186 | |
B | GLY69 | |
B | ASP134 | |
B | ARG166 | |
B | PHE186 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
A | TYR194 | |
B | TYR194 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7107641 |
Chain | Residue | Details |
A | THR2 | |
B | THR2 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P00493 |
Chain | Residue | Details |
A | SER103 | |
B | SER103 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P27605 |
Chain | Residue | Details |
A | MET142 | |
B | MET142 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | VAL115 | |
B | VAL115 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
A | GLU133 | |
A | ASP134 | |
A | ASP137 | |
A | LYS165 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
B | GLU133 | |
B | ASP134 | |
B | ASP137 | |
B | LYS165 |
site_id | CSA3 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
A | GLU133 | |
A | ASP134 | |
A | ARG169 | |
A | ASP137 | |
A | LYS165 |
site_id | CSA4 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1a95 |
Chain | Residue | Details |
B | GLU133 | |
B | ASP134 | |
B | ARG169 | |
B | ASP137 | |
B | LYS165 |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 48 |
Chain | Residue | Details |
A | ASP134 | attractive charge-charge interaction, electrostatic stabiliser |
A | ILE135 | attractive charge-charge interaction, electrostatic stabiliser |
A | THR138 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | VAL187 | electrostatic stabiliser |
A | ASP200 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 48 |
Chain | Residue | Details |
B | ASP134 | attractive charge-charge interaction, electrostatic stabiliser |
B | ILE135 | attractive charge-charge interaction, electrostatic stabiliser |
B | THR138 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | VAL187 | electrostatic stabiliser |
B | ASP200 | electrostatic stabiliser |