1HL3

CtBP/BARS in ternary complex with NAD(H) and PIDLSKK peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003714	molecular_function	transcription corepressor activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE NAD A 600

Chain	Residue
A	SER89
A	TYR195
A	HIS225
A	CYS226
A	GLY227
A	ASN229
A	ASN232
A	THR253
A	ALA254
A	ARG255
A	ASP279
A	THR117
A	VAL280
A	HIS304
A	TRP307
A	GLY170
A	GLY172
A	ARG173
A	VAL174
A	TYR192
A	ASP193
A	PRO194

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Functional Information from PROSITE/UniProt

site_id	PS00065
Number of Residues	28
Details	D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGIIGlGRVGqavalrakafgfn.VLfYD

Chain	Residue	Details
A	LEU166-ASP193

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site_id	PS00671
Number of Residues	17
Details	D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MRqGaFLVNtARGgLVD

Chain	Residue	Details
A	MET244-ASP260

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	ARG255
A	GLU284

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	HIS304

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:12805226, ECO:0000269|PubMed:16940172

Chain	Residue	Details
A	SER89
A	ILE169
A	ASP193
A	CYS226
A	THR253
A	ASP279

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q13363

Chain	Residue	Details
A	SER289

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1psd

Chain	Residue	Details
A	HIS304
A	GLU284

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