1HI2
Eosinophil-derived Neurotoxin (EDN) - Sulphate Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001530 | molecular_function | lipopolysaccharide binding |
| A | 0002227 | biological_process | innate immune response in mucosa |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004522 | molecular_function | ribonuclease A activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005764 | cellular_component | lysosome |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006935 | biological_process | chemotaxis |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043152 | biological_process | induction of bacterial agglutination |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0051607 | biological_process | defense response to virus |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 957 |
| Chain | Residue |
| A | GLN14 |
| A | HIS15 |
| A | HIS129 |
| A | LEU130 |
| A | HOH2015 |
| A | HOH2110 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 958 |
| Chain | Residue |
| A | GLN40 |
| A | ARG36 |
| A | LYS38 |
| A | ASN39 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKnqNTF |
| Chain | Residue | Details |
| A | CYS37-PHE43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"PubMed","id":"18694936","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"C-linked (Man) tryptophan","featureId":"CAR_000004","evidences":[{"source":"PubMed","id":"7947762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9450956","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4y |
| Chain | Residue | Details |
| A | LYS38 | |
| A | HIS15 | |
| A | HIS129 |
