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1HHK

THE ANTIGENIC IDENTITY OF PEPTIDE(SLASH)MHC COMPLEXES: A COMPARISON OF THE CONFORMATION OF FIVE PEPTIDES PRESENTED BY HLA-A2

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0032092biological_processpositive regulation of protein binding
B0033077biological_processT cell differentiation in thymus
B0034756biological_processregulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1900121biological_processnegative regulation of receptor binding
B1900122biological_processpositive regulation of receptor binding
B1904434biological_processpositive regulation of ferrous iron binding
B1904437biological_processpositive regulation of transferrin receptor binding
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
E0000139cellular_componentGolgi membrane
E0001913biological_processT cell mediated cytotoxicity
E0001916biological_processpositive regulation of T cell mediated cytotoxicity
E0002237biological_processresponse to molecule of bacterial origin
E0002376biological_processimmune system process
E0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
E0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
E0002502biological_processpeptide antigen assembly with MHC class I protein complex
E0002503biological_processpeptide antigen assembly with MHC class II protein complex
E0002726biological_processpositive regulation of T cell cytokine production
E0005198molecular_functionstructural molecule activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005765cellular_componentlysosomal membrane
E0005783cellular_componentendoplasmic reticulum
E0005788cellular_componentendoplasmic reticulum lumen
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0005925cellular_componentfocal adhesion
E0006826biological_processiron ion transport
E0006879biological_processintracellular iron ion homeostasis
E0006955biological_processimmune response
E0007608biological_processsensory perception of smell
E0007611biological_processlearning or memory
E0009897cellular_componentexternal side of plasma membrane
E0009986cellular_componentcell surface
E0010977biological_processnegative regulation of neuron projection development
E0012507cellular_componentER to Golgi transport vesicle membrane
E0016020cellular_componentmembrane
E0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
E0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
E0023026molecular_functionMHC class II protein complex binding
E0030670cellular_componentphagocytic vesicle membrane
E0031901cellular_componentearly endosome membrane
E0031902cellular_componentlate endosome membrane
E0031905cellular_componentearly endosome lumen
E0032092biological_processpositive regulation of protein binding
E0033077biological_processT cell differentiation in thymus
E0034756biological_processregulation of iron ion transport
E0035580cellular_componentspecific granule lumen
E0042026biological_processprotein refolding
E0042605molecular_functionpeptide antigen binding
E0042612cellular_componentMHC class I protein complex
E0042613cellular_componentMHC class II protein complex
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0042824cellular_componentMHC class I peptide loading complex
E0045646biological_processregulation of erythrocyte differentiation
E0048260biological_processpositive regulation of receptor-mediated endocytosis
E0050680biological_processnegative regulation of epithelial cell proliferation
E0050768biological_processnegative regulation of neurogenesis
E0050778biological_processpositive regulation of immune response
E0050870biological_processpositive regulation of T cell activation
E0051289biological_processprotein homotetramerization
E0055038cellular_componentrecycling endosome membrane
E0060586biological_processmulticellular organismal-level iron ion homeostasis
E0070062cellular_componentextracellular exosome
E0071281biological_processcellular response to iron ion
E0071283biological_processcellular response to iron(III) ion
E0071316biological_processcellular response to nicotine
E1900121biological_processnegative regulation of receptor binding
E1900122biological_processpositive regulation of receptor binding
E1904434biological_processpositive regulation of ferrous iron binding
E1904437biological_processpositive regulation of transferrin receptor binding
E1904724cellular_componenttertiary granule lumen
E1990000biological_processamyloid fibril formation
E1990712cellular_componentHFE-transferrin receptor complex
E2000774biological_processpositive regulation of cellular senescence
E2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
ChainResidueDetails
ATYR257-HIS263
BTYR78-HIS84

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
ChainResidueDetails
BGLN2
DTHR143
DLYS146
DTYR171
EGLN2
AGLU89
AGLU148
AHIS151
ALYS176
DTYR7
DTHR73
DTYR84

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
ChainResidueDetails
BILE1
EILE1
DTYR116
DTYR159

site_idSWS_FT_FI3
Number of Residues12
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
ChainResidueDetails
BLYS19
ELYS58
ELYS91
ELYS94
BLYS41
BLYS48
BLYS58
BLYS91
BLYS94
ELYS19
ELYS41
ELYS48

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AGLY91
DASN86

217705

PDB entries from 2024-03-27

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