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1HFK

Asparaginase from Erwinia chrysanthemi, hexagonal form with weak sulfate

Functional Information from GO Data
ChainGOidnamespacecontents
A0004067molecular_functionasparaginase activity
A0006520biological_processamino acid metabolic process
A0006528biological_processasparagine metabolic process
A0016787molecular_functionhydrolase activity
C0004067molecular_functionasparaginase activity
C0006520biological_processamino acid metabolic process
C0006528biological_processasparagine metabolic process
C0016787molecular_functionhydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 400
ChainResidue
AALA61
ASER62
AGLU63
AGLY94
ATHR95
AASP96

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 C 400
ChainResidue
CTHR95
CASP96
CHOH2215
CHOH2216
CSER62
CGLU63
CGLY94

Functional Information from PROSITE/UniProt
site_idPS00144
Number of Residues9
DetailsASN_GLN_ASE_1 Asparaginase / glutaminase active site signature 1. IlATGGTIA
ChainResidueDetails
AILE9-ALA17

site_idPS00917
Number of Residues11
DetailsASN_GLN_ASE_2 Asparaginase / glutaminase active site signature 2. GvVitHGTDTV
ChainResidueDetails
AGLY88-VAL98

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: O-isoaspartyl threonine intermediate => ECO:0000255|PROSITE-ProRule:PRU10099, ECO:0000255|PROSITE-ProRule:PRU10100, ECO:0000269|PubMed:11755201, ECO:0000269|PubMed:8348975
ChainResidueDetails
ATHR15
CTHR15

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
ASER62
ATHR95
CSER62
CTHR95

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 3eca
ChainResidueDetails
ATHR15
ATHR95
AASP96
ALYS168

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 3eca
ChainResidueDetails
CTHR15
CTHR95
CASP96
CLYS168

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 3eca
ChainResidueDetails
AVAL284
CTHR15
CTHR95

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 3eca
ChainResidueDetails
ATHR15
ATHR95
CVAL284

226707

PDB entries from 2024-10-30

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