Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0009098 | biological_process | L-leucine biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE NAD A 400 |
Chain | Residue |
A | ILE11 |
A | SER275 |
A | ALA276 |
A | ASP278 |
A | ILE279 |
A | ASN286 |
A | VAL72 |
A | GLY73 |
A | GLY74 |
A | ASP78 |
A | GLU87 |
A | LEU254 |
A | HIS273 |
A | GLY274 |
Functional Information from PROSITE/UniProt
site_id | PS00470 |
Number of Residues | 20 |
Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NIFGDIlSDlaSvlp.GSLGL |
Chain | Residue | Details |
A | ASN237-LEU256 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLY74 | |
A | GLY274 | |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ARG94 | |
A | ARG104 | |
A | ARG132 | |
A | ASP217 | |
A | ASP241 | |
A | ASP245 | |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | SITE: Important for catalysis |
Chain | Residue | Details |
A | TYR139 | |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | SITE: Important for catalysis => ECO:0000250 |
Chain | Residue | Details |
A | LYS185 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
A | TYR139 | |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a05 |
Chain | Residue | Details |
A | LYS185 | |
A | ASP217 | |