1HE2

Human biliverdin IX beta reductase: NADP/biliverdin IX alpha ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004074	molecular_function	biliverdin reductase [NAD(P)H] activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0030219	biological_process	megakaryocyte differentiation
A	0035605	molecular_function	peptidyl-cysteine S-nitrosylase activity
A	0042167	biological_process	heme catabolic process
A	0042602	molecular_function	riboflavin reductase (NADPH) activity
A	0046627	biological_process	negative regulation of insulin receptor signaling pathway
A	0052873	molecular_function	FMN reductase (NADPH) activity
A	0052874	molecular_function	FMN reductase (NADH) activity
A	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	38
Details	BINDING SITE FOR RESIDUE NAP A1206

Chain	Residue
A	GLY10
A	LEU74
A	LEU75
A	GLY76
A	ARG78
A	MET87
A	CYS109
A	THR110
A	SER111
A	HIS132
A	PRO151
A	THR12
A	PRO152
A	HIS153
A	ILE154
A	BLA1207
A	HOH2019
A	HOH2030
A	HOH2067
A	HOH2153
A	HOH2221
A	HOH2277
A	GLY13
A	HOH2278
A	HOH2279
A	HOH2280
A	HOH2281
A	HOH2282
A	HOH2283
A	HOH2284
A	HOH2285
A	HOH2286
A	GLN14
A	THR15
A	ARG35
A	ARG39
A	ASP54
A	VAL55

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BLA A1207

Chain	Residue
A	PHE113
A	TRP116
A	HIS153
A	NAP1206
A	HOH2191
A	HOH2287

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"S-nitroso-cysteine intermediate; for S-nitroso-CoA-dependent nitrosyltransferase activity","evidences":[{"source":"PubMed","id":"38056462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---