1HBO
METHYL-COENZYME M REDUCTASE MCR-RED1-SILENT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0015948 | biological_process | methanogenesis |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0015948 | biological_process | methanogenesis |
| B | 0016740 | molecular_function | transferase activity |
| B | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0015948 | biological_process | methanogenesis |
| C | 0016740 | molecular_function | transferase activity |
| C | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0015948 | biological_process | methanogenesis |
| D | 0016740 | molecular_function | transferase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0015948 | biological_process | methanogenesis |
| E | 0016740 | molecular_function | transferase activity |
| E | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0015948 | biological_process | methanogenesis |
| F | 0016740 | molecular_function | transferase activity |
| F | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ZN A 1556 |
| Chain | Residue |
| A | ARG102 |
| A | SER215 |
| A | ARG216 |
| A | CYS218 |
| D | ARG102 |
| D | SER215 |
| D | ARG216 |
| D | CYS218 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 1557 |
| Chain | Residue |
| A | PHE14 |
| A | HOH2023 |
| A | HOH2028 |
| A | HOH2034 |
| A | HOH2037 |
| A | LYS11 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 1558 |
| Chain | Residue |
| A | ARG270 |
| A | HOH2255 |
| A | HOH2430 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1559 |
| Chain | Residue |
| A | ALA544 |
| A | THR547 |
| A | PRO548 |
| A | HOH2420 |
| A | HOH2421 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 1560 |
| Chain | Residue |
| A | PRO58 |
| A | ILE60 |
| A | THR62 |
| A | HOH2106 |
| A | HOH2108 |
| A | HOH2109 |
| D | HOH2160 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 1561 |
| Chain | Residue |
| A | HOH2167 |
| A | HOH2336 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1562 |
| Chain | Residue |
| A | HOH2017 |
| A | HOH2018 |
| A | HOH2033 |
| A | HOH2051 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 1445 |
| Chain | Residue |
| A | HOH2098 |
| B | ASN441 |
| B | HOH2376 |
| D | HOH2189 |
| D | HOH2190 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 1446 |
| Chain | Residue |
| B | ARG235 |
| B | HOH2111 |
| B | HOH2255 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 1447 |
| Chain | Residue |
| B | ASP99 |
| B | THR101 |
| B | HOH2123 |
| B | HOH2137 |
| B | HOH2142 |
| B | HOH2143 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 1250 |
| Chain | Residue |
| C | GLU30 |
| C | HOH2025 |
| C | HOH2054 |
| C | HOH2057 |
| C | HOH2153 |
| F | HOH2044 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 1556 |
| Chain | Residue |
| D | LYS11 |
| D | PHE14 |
| D | HOH2017 |
| D | HOH2020 |
| D | HOH2025 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 1557 |
| Chain | Residue |
| A | HOH2172 |
| D | PRO58 |
| D | ILE60 |
| D | THR62 |
| D | HOH2093 |
| D | HOH2094 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL E 1445 |
| Chain | Residue |
| E | ARG235 |
| E | HOH2288 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG F 1249 |
| Chain | Residue |
| C | HOH2046 |
| F | GLU30 |
| F | HOH2022 |
| F | HOH2049 |
| F | HOH2052 |
| F | HOH2142 |
| site_id | BC7 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE F43 A 1550 |
| Chain | Residue |
| C | LYS153 |
| C | SER154 |
| C | VAL155 |
| C | HIS156 |
| C | HIS158 |
| C | HOH2164 |
| C | HOH2167 |
| D | ALA144 |
| D | VAL145 |
| D | VAL146 |
| D | GLN147 |
| D | GLN230 |
| D | MET233 |
| D | ALA243 |
| A | GLY326 |
| A | GLY327 |
| A | VAL328 |
| A | GLY329 |
| A | PHE330 |
| A | THR331 |
| A | GLN332 |
| A | TYR333 |
| A | PHE396 |
| A | GLY397 |
| A | GLY442 |
| A | PHE443 |
| A | COM1552 |
| A | HOH2424 |
| A | HOH2425 |
| A | HOH2426 |
| A | HOH2427 |
| A | HOH2428 |
| A | HOH2429 |
| B | SER365 |
| B | ILE366 |
| B | TYR367 |
| C | LEU117 |
| C | SER118 |
| C | GLY119 |
| site_id | BC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE TP7 A 1551 |
| Chain | Residue |
| A | ARG270 |
| A | LEU320 |
| A | MET324 |
| A | SER325 |
| A | PHE330 |
| A | PHE443 |
| A | MET480 |
| A | ASN481 |
| A | VAL482 |
| A | HOH2430 |
| A | HOH2431 |
| A | HOH2432 |
| A | HOH2433 |
| B | PHE362 |
| B | TYR367 |
| B | GLY369 |
| B | HIS379 |
| B | HOH2332 |
| D | ARG225 |
| D | LYS256 |
| D | MHS257 |
| site_id | BC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE COM A 1552 |
| Chain | Residue |
| A | TYR333 |
| A | PHE443 |
| A | TYR444 |
| A | F431550 |
| B | PHE361 |
| B | TYR367 |
| C | LEU117 |
| C | ARG120 |
| C | HOH2135 |
| site_id | CC1 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE F43 D 1550 |
| Chain | Residue |
| A | ALA144 |
| A | VAL145 |
| A | VAL146 |
| A | GLN147 |
| A | GLN230 |
| A | MET233 |
| A | ALA243 |
| A | HOH2228 |
| D | GLY326 |
| D | GLY327 |
| D | VAL328 |
| D | GLY329 |
| D | PHE330 |
| D | THR331 |
| D | GLN332 |
| D | TYR333 |
| D | PHE396 |
| D | GLY397 |
| D | GLY442 |
| D | PHE443 |
| D | COM1552 |
| D | HOH2338 |
| D | HOH2419 |
| D | HOH2420 |
| D | HOH2421 |
| D | HOH2422 |
| D | HOH2423 |
| E | SER365 |
| E | ILE366 |
| E | TYR367 |
| F | LEU117 |
| F | SER118 |
| F | GLY119 |
| F | LYS153 |
| F | SER154 |
| F | VAL155 |
| F | HIS156 |
| F | HIS158 |
| F | HOH2153 |
| site_id | CC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE TP7 D 1551 |
| Chain | Residue |
| A | ARG225 |
| A | LYS256 |
| A | MHS257 |
| D | ARG270 |
| D | MET324 |
| D | SER325 |
| D | PHE330 |
| D | PHE443 |
| D | MET480 |
| D | ASN481 |
| D | VAL482 |
| D | HOH2291 |
| D | HOH2368 |
| D | HOH2424 |
| D | HOH2425 |
| D | HOH2426 |
| E | TYR367 |
| E | GLY369 |
| E | HIS379 |
| E | ILE380 |
| E | HOH2311 |
| site_id | CC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE COM D 1552 |
| Chain | Residue |
| D | TYR333 |
| D | PHE443 |
| D | TYR444 |
| D | F431550 |
| E | PHE361 |
| E | TYR367 |
| F | LEU117 |
| F | ARG120 |
| F | HOH2122 |
| site_id | CC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1553 |
| Chain | Residue |
| A | ASP170 |
| A | ALA173 |
| A | ASP174 |
| A | ASP183 |
| A | ASN185 |
| A | HOH2434 |
| A | HOH2435 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1554 |
| Chain | Residue |
| A | VAL519 |
| A | LYS531 |
| A | PHE537 |
| A | GLU538 |
| A | HOH2400 |
| A | HOH2402 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1555 |
| Chain | Residue |
| A | LYS4 |
| A | ASP345 |
| A | TYR348 |
| A | GLU352 |
| A | TYR380 |
| A | HOH2007 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1444 |
| Chain | Residue |
| B | LYS3 |
| B | GLU25 |
| B | SER28 |
| B | ARG31 |
| B | GLU234 |
| B | HOH2379 |
| E | VAL95 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 1249 |
| Chain | Residue |
| C | TYR109 |
| C | ARG110 |
| C | ASP129 |
| C | HOH2131 |
| C | HOH2254 |
| C | HOH2255 |
| C | HOH2256 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 1553 |
| Chain | Residue |
| D | ASP170 |
| D | ASP174 |
| D | ASP183 |
| D | ASN185 |
| D | HOH2195 |
| D | HOH2197 |
| site_id | DC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 1554 |
| Chain | Residue |
| D | GLN291 |
| D | ARG294 |
| D | PHE513 |
| D | ASP515 |
| D | PHE520 |
| D | ASP521 |
| D | PHE522 |
| D | THR523 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 1555 |
| Chain | Residue |
| D | LYS4 |
| D | ASP345 |
| D | TYR348 |
| D | GLU352 |
| D | TYR380 |
| D | HOH2001 |
| site_id | DC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL E 1444 |
| Chain | Residue |
| B | VAL95 |
| E | LYS3 |
| E | GLU25 |
| E | SER28 |
| E | LEU30 |
| E | ARG31 |
| E | GLU234 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y |
| Chain | Residue | Details |
| C | GLN121 | |
| F | GLN121 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27140643, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:1MRO, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y, ECO:0007744|PDB:5G0R |
| Chain | Residue | Details |
| B | GLY370 | |
| E | GLY370 | |
| D | TRP226 | |
| D | MHS257 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: in chain B => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27140643, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:1MRO, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y, ECO:0007744|PDB:5G0R |
| Chain | Residue | Details |
| A | AGM271 | |
| D | AGM271 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:1MRO, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y |
| Chain | Residue | Details |
| A | ALA334 | |
| A | GL3445 | |
| D | ALA334 | |
| D | GL3445 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Pros-methylhistidine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
| Chain | Residue | Details |
| A | ALA258 | |
| D | ALA258 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-methylarginine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
| Chain | Residue | Details |
| A | ALA272 | |
| D | ALA272 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: 2-methylglutamine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
| Chain | Residue | Details |
| A | ARG401 | |
| D | ARG401 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: 1-thioglycine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
| Chain | Residue | Details |
| A | TYR446 | |
| D | TYR446 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: (Z)-2,3-didehydroaspartate => ECO:0000269|PubMed:27467699 |
| Chain | Residue | Details |
| A | GLN451 | |
| D | GLN451 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: S-methylcysteine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
| Chain | Residue | Details |
| A | GLY453 | |
| D | GLY453 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 156 |
| Chain | Residue | Details |
| B | GLY368 | electrostatic stabiliser, proton acceptor, proton donor, proton relay, radical stabiliser |
| A | ALA334 | electrostatic stabiliser, radical stabiliser |
| A | TYR446 | single electron acceptor, single electron donor, single electron relay |
| A | VAL482 | activator, electrostatic stabiliser, proton acceptor, proton donor, proton relay |
| site_id | MCSA2 |
| Number of Residues | 1 |
| Details | M-CSA 156 |
| Chain | Residue | Details |
| E | GLY368 | electrostatic stabiliser, proton acceptor, proton donor, proton relay, radical stabiliser |
| D | ALA334 | electrostatic stabiliser, radical stabiliser |
| D | TYR446 | single electron acceptor, single electron donor, single electron relay |
| D | VAL482 | activator, electrostatic stabiliser, proton acceptor, proton donor, proton relay |
