1HBO
METHYL-COENZYME M REDUCTASE MCR-RED1-SILENT
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0015948 | biological_process | methanogenesis |
A | 0016740 | molecular_function | transferase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0015948 | biological_process | methanogenesis |
B | 0016740 | molecular_function | transferase activity |
B | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0015948 | biological_process | methanogenesis |
C | 0016740 | molecular_function | transferase activity |
C | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0015948 | biological_process | methanogenesis |
D | 0016740 | molecular_function | transferase activity |
D | 0046872 | molecular_function | metal ion binding |
D | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0015948 | biological_process | methanogenesis |
E | 0016740 | molecular_function | transferase activity |
E | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0015948 | biological_process | methanogenesis |
F | 0016740 | molecular_function | transferase activity |
F | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE ZN A 1556 |
Chain | Residue |
A | ARG102 |
A | SER215 |
A | ARG216 |
A | CYS218 |
D | ARG102 |
D | SER215 |
D | ARG216 |
D | CYS218 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 1557 |
Chain | Residue |
A | PHE14 |
A | HOH2023 |
A | HOH2028 |
A | HOH2034 |
A | HOH2037 |
A | LYS11 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA A 1558 |
Chain | Residue |
A | ARG270 |
A | HOH2255 |
A | HOH2430 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA A 1559 |
Chain | Residue |
A | ALA544 |
A | THR547 |
A | PRO548 |
A | HOH2420 |
A | HOH2421 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA A 1560 |
Chain | Residue |
A | PRO58 |
A | ILE60 |
A | THR62 |
A | HOH2106 |
A | HOH2108 |
A | HOH2109 |
D | HOH2160 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG A 1561 |
Chain | Residue |
A | HOH2167 |
A | HOH2336 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 1562 |
Chain | Residue |
A | HOH2017 |
A | HOH2018 |
A | HOH2033 |
A | HOH2051 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA B 1445 |
Chain | Residue |
A | HOH2098 |
B | ASN441 |
B | HOH2376 |
D | HOH2189 |
D | HOH2190 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B 1446 |
Chain | Residue |
B | ARG235 |
B | HOH2111 |
B | HOH2255 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA B 1447 |
Chain | Residue |
B | ASP99 |
B | THR101 |
B | HOH2123 |
B | HOH2137 |
B | HOH2142 |
B | HOH2143 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 1250 |
Chain | Residue |
C | GLU30 |
C | HOH2025 |
C | HOH2054 |
C | HOH2057 |
C | HOH2153 |
F | HOH2044 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA D 1556 |
Chain | Residue |
D | LYS11 |
D | PHE14 |
D | HOH2017 |
D | HOH2020 |
D | HOH2025 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA D 1557 |
Chain | Residue |
A | HOH2172 |
D | PRO58 |
D | ILE60 |
D | THR62 |
D | HOH2093 |
D | HOH2094 |
site_id | BC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL E 1445 |
Chain | Residue |
E | ARG235 |
E | HOH2288 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG F 1249 |
Chain | Residue |
C | HOH2046 |
F | GLU30 |
F | HOH2022 |
F | HOH2049 |
F | HOH2052 |
F | HOH2142 |
site_id | BC7 |
Number of Residues | 39 |
Details | BINDING SITE FOR RESIDUE F43 A 1550 |
Chain | Residue |
C | LYS153 |
C | SER154 |
C | VAL155 |
C | HIS156 |
C | HIS158 |
C | HOH2164 |
C | HOH2167 |
D | ALA144 |
D | VAL145 |
D | VAL146 |
D | GLN147 |
D | GLN230 |
D | MET233 |
D | ALA243 |
A | GLY326 |
A | GLY327 |
A | VAL328 |
A | GLY329 |
A | PHE330 |
A | THR331 |
A | GLN332 |
A | TYR333 |
A | PHE396 |
A | GLY397 |
A | GLY442 |
A | PHE443 |
A | COM1552 |
A | HOH2424 |
A | HOH2425 |
A | HOH2426 |
A | HOH2427 |
A | HOH2428 |
A | HOH2429 |
B | SER365 |
B | ILE366 |
B | TYR367 |
C | LEU117 |
C | SER118 |
C | GLY119 |
site_id | BC8 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE TP7 A 1551 |
Chain | Residue |
A | ARG270 |
A | LEU320 |
A | MET324 |
A | SER325 |
A | PHE330 |
A | PHE443 |
A | MET480 |
A | ASN481 |
A | VAL482 |
A | HOH2430 |
A | HOH2431 |
A | HOH2432 |
A | HOH2433 |
B | PHE362 |
B | TYR367 |
B | GLY369 |
B | HIS379 |
B | HOH2332 |
D | ARG225 |
D | LYS256 |
D | MHS257 |
site_id | BC9 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE COM A 1552 |
Chain | Residue |
A | TYR333 |
A | PHE443 |
A | TYR444 |
A | F431550 |
B | PHE361 |
B | TYR367 |
C | LEU117 |
C | ARG120 |
C | HOH2135 |
site_id | CC1 |
Number of Residues | 39 |
Details | BINDING SITE FOR RESIDUE F43 D 1550 |
Chain | Residue |
A | ALA144 |
A | VAL145 |
A | VAL146 |
A | GLN147 |
A | GLN230 |
A | MET233 |
A | ALA243 |
A | HOH2228 |
D | GLY326 |
D | GLY327 |
D | VAL328 |
D | GLY329 |
D | PHE330 |
D | THR331 |
D | GLN332 |
D | TYR333 |
D | PHE396 |
D | GLY397 |
D | GLY442 |
D | PHE443 |
D | COM1552 |
D | HOH2338 |
D | HOH2419 |
D | HOH2420 |
D | HOH2421 |
D | HOH2422 |
D | HOH2423 |
E | SER365 |
E | ILE366 |
E | TYR367 |
F | LEU117 |
F | SER118 |
F | GLY119 |
F | LYS153 |
F | SER154 |
F | VAL155 |
F | HIS156 |
F | HIS158 |
F | HOH2153 |
site_id | CC2 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE TP7 D 1551 |
Chain | Residue |
A | ARG225 |
A | LYS256 |
A | MHS257 |
D | ARG270 |
D | MET324 |
D | SER325 |
D | PHE330 |
D | PHE443 |
D | MET480 |
D | ASN481 |
D | VAL482 |
D | HOH2291 |
D | HOH2368 |
D | HOH2424 |
D | HOH2425 |
D | HOH2426 |
E | TYR367 |
E | GLY369 |
E | HIS379 |
E | ILE380 |
E | HOH2311 |
site_id | CC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE COM D 1552 |
Chain | Residue |
D | TYR333 |
D | PHE443 |
D | TYR444 |
D | F431550 |
E | PHE361 |
E | TYR367 |
F | LEU117 |
F | ARG120 |
F | HOH2122 |
site_id | CC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 1553 |
Chain | Residue |
A | ASP170 |
A | ALA173 |
A | ASP174 |
A | ASP183 |
A | ASN185 |
A | HOH2434 |
A | HOH2435 |
site_id | CC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 1554 |
Chain | Residue |
A | VAL519 |
A | LYS531 |
A | PHE537 |
A | GLU538 |
A | HOH2400 |
A | HOH2402 |
site_id | CC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 1555 |
Chain | Residue |
A | LYS4 |
A | ASP345 |
A | TYR348 |
A | GLU352 |
A | TYR380 |
A | HOH2007 |
site_id | CC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 1444 |
Chain | Residue |
B | LYS3 |
B | GLU25 |
B | SER28 |
B | ARG31 |
B | GLU234 |
B | HOH2379 |
E | VAL95 |
site_id | CC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL C 1249 |
Chain | Residue |
C | TYR109 |
C | ARG110 |
C | ASP129 |
C | HOH2131 |
C | HOH2254 |
C | HOH2255 |
C | HOH2256 |
site_id | CC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL D 1553 |
Chain | Residue |
D | ASP170 |
D | ASP174 |
D | ASP183 |
D | ASN185 |
D | HOH2195 |
D | HOH2197 |
site_id | DC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL D 1554 |
Chain | Residue |
D | GLN291 |
D | ARG294 |
D | PHE513 |
D | ASP515 |
D | PHE520 |
D | ASP521 |
D | PHE522 |
D | THR523 |
site_id | DC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL D 1555 |
Chain | Residue |
D | LYS4 |
D | ASP345 |
D | TYR348 |
D | GLU352 |
D | TYR380 |
D | HOH2001 |
site_id | DC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL E 1444 |
Chain | Residue |
B | VAL95 |
E | LYS3 |
E | GLU25 |
E | SER28 |
E | LEU30 |
E | ARG31 |
E | GLU234 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y |
Chain | Residue | Details |
C | GLN121 | |
F | GLN121 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27140643, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:1MRO, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y, ECO:0007744|PDB:5G0R |
Chain | Residue | Details |
B | GLY370 | |
E | GLY370 | |
D | TRP226 | |
D | MHS257 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: in chain B => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27140643, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:1MRO, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y, ECO:0007744|PDB:5G0R |
Chain | Residue | Details |
A | AGM271 | |
D | AGM271 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:1MRO, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y |
Chain | Residue | Details |
A | ALA334 | |
A | GL3445 | |
D | ALA334 | |
D | GL3445 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Pros-methylhistidine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
Chain | Residue | Details |
A | ALA258 | |
D | ALA258 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: 5-methylarginine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
Chain | Residue | Details |
A | ALA272 | |
D | ALA272 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: 2-methylglutamine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
Chain | Residue | Details |
A | ARG401 | |
D | ARG401 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: 1-thioglycine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
Chain | Residue | Details |
A | TYR446 | |
D | TYR446 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: (Z)-2,3-didehydroaspartate => ECO:0000269|PubMed:27467699 |
Chain | Residue | Details |
A | GLN451 | |
D | GLN451 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: S-methylcysteine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
Chain | Residue | Details |
A | GLY453 | |
D | GLY453 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1mro |
Chain | Residue | Details |
A | GLY465 | |
A | ASP501 | |
B | TYR367 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1mro |
Chain | Residue | Details |
D | GLY465 | |
D | ASP501 | |
E | TYR367 |
site_id | MCSA1 |
Number of Residues | 1 |
Details | M-CSA 156 |
Chain | Residue | Details |
B | GLY368 | electrostatic stabiliser, proton acceptor, proton donor, proton relay, radical stabiliser |
A | ALA334 | electrostatic stabiliser, radical stabiliser |
A | TYR446 | single electron acceptor, single electron donor, single electron relay |
A | VAL482 | activator, electrostatic stabiliser, proton acceptor, proton donor, proton relay |
site_id | MCSA2 |
Number of Residues | 1 |
Details | M-CSA 156 |
Chain | Residue | Details |
E | GLY368 | electrostatic stabiliser, proton acceptor, proton donor, proton relay, radical stabiliser |
D | ALA334 | electrostatic stabiliser, radical stabiliser |
D | TYR446 | single electron acceptor, single electron donor, single electron relay |
D | VAL482 | activator, electrostatic stabiliser, proton acceptor, proton donor, proton relay |