1HBM
METHYL-COENZYME M REDUCTASE ENZYME PRODUCT COMPLEX
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0015948 | biological_process | methanogenesis |
A | 0016740 | molecular_function | transferase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0015948 | biological_process | methanogenesis |
B | 0016740 | molecular_function | transferase activity |
B | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0015948 | biological_process | methanogenesis |
C | 0016740 | molecular_function | transferase activity |
C | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0015948 | biological_process | methanogenesis |
D | 0016740 | molecular_function | transferase activity |
D | 0046872 | molecular_function | metal ion binding |
D | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0015948 | biological_process | methanogenesis |
E | 0016740 | molecular_function | transferase activity |
E | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0015948 | biological_process | methanogenesis |
F | 0016740 | molecular_function | transferase activity |
F | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A1556 |
Chain | Residue |
A | LYS11 |
A | PHE14 |
A | HOH2027 |
A | HOH2035 |
A | HOH2036 |
A | HOH2044 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA A1557 |
Chain | Residue |
D | GOL1553 |
D | HOH2437 |
A | ARG270 |
A | HOH2261 |
A | HOH2420 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA A1558 |
Chain | Residue |
A | ALA544 |
A | THR547 |
A | PRO548 |
A | HOH2407 |
A | HOH2410 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A1559 |
Chain | Residue |
A | PRO58 |
A | ILE60 |
A | THR62 |
A | HOH2110 |
A | HOH2113 |
D | HOH2172 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA B1445 |
Chain | Residue |
A | HOH2102 |
B | ASN441 |
B | HOH2368 |
D | HOH2197 |
D | HOH2198 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B1446 |
Chain | Residue |
B | ARG235 |
B | HOH2109 |
B | HOH2248 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA B1447 |
Chain | Residue |
B | ASP99 |
B | THR101 |
B | HOH2122 |
B | HOH2140 |
B | HOH2145 |
B | HOH2147 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C1250 |
Chain | Residue |
C | GLU30 |
C | HOH2027 |
C | HOH2055 |
C | HOH2058 |
C | HOH2152 |
F | HOH2040 |
site_id | AC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE ZN D1556 |
Chain | Residue |
A | ARG102 |
A | SER215 |
A | ARG216 |
A | CYS218 |
D | ARG102 |
D | SER215 |
D | ARG216 |
D | CYS218 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA D1557 |
Chain | Residue |
D | LYS11 |
D | PHE14 |
D | HOH2016 |
D | HOH2017 |
D | HOH2022 |
D | HOH2028 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA D1558 |
Chain | Residue |
A | GOL1552 |
D | ARG270 |
D | HOH2139 |
D | HOH2266 |
D | HOH2432 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA D1559 |
Chain | Residue |
A | HOH2174 |
D | PRO58 |
D | ILE60 |
D | THR62 |
D | HOH2098 |
D | HOH2103 |
site_id | BC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL E1445 |
Chain | Residue |
E | ARG235 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG F1249 |
Chain | Residue |
C | HOH2050 |
F | GLU30 |
F | HOH2018 |
F | HOH2044 |
F | HOH2048 |
F | HOH2143 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG F1250 |
Chain | Residue |
E | HOH2036 |
E | HOH2037 |
E | HOH2100 |
E | HOH2101 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG F1251 |
Chain | Residue |
A | HOH2018 |
A | HOH2019 |
A | HOH2021 |
A | HOH2040 |
A | HOH2058 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG F1252 |
Chain | Residue |
A | HOH2025 |
A | HOH2053 |
A | HOH2330 |
site_id | BC9 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE F43 A1550 |
Chain | Residue |
A | HOH2413 |
A | HOH2414 |
A | HOH2415 |
A | HOH2416 |
A | HOH2417 |
B | SER365 |
B | ILE366 |
B | TYR367 |
C | LEU117 |
C | SER118 |
C | GLY119 |
C | LYS153 |
C | SER154 |
C | VAL155 |
C | HIS156 |
C | HIS158 |
C | HOH2126 |
C | HOH2160 |
D | ALA144 |
D | VAL145 |
D | VAL146 |
D | GLN147 |
D | GLN230 |
D | MET233 |
D | ALA243 |
A | GLY326 |
A | GLY327 |
A | VAL328 |
A | GLY329 |
A | PHE330 |
A | THR331 |
A | GLN332 |
A | TYR333 |
A | GLY397 |
A | GLY442 |
A | PHE443 |
A | SHT1551 |
A | HOH2334 |
site_id | CC1 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE SHT A1551 |
Chain | Residue |
A | ARG270 |
A | LEU320 |
A | MET324 |
A | SER325 |
A | PHE330 |
A | TYR333 |
A | PHE443 |
A | MET480 |
A | VAL482 |
A | F431550 |
A | HOH2418 |
A | HOH2419 |
A | HOH2420 |
A | HOH2421 |
A | HOH2422 |
A | HOH2423 |
B | TYR367 |
B | GLY368 |
B | GLY369 |
B | HIS379 |
B | ILE380 |
D | ARG225 |
D | LYS256 |
D | MHS257 |
site_id | CC2 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE F43 D1550 |
Chain | Residue |
A | ALA144 |
A | VAL145 |
A | VAL146 |
A | GLN147 |
A | GLN230 |
A | MET233 |
A | ALA243 |
A | HOH2176 |
A | HOH2235 |
D | GLY326 |
D | GLY327 |
D | VAL328 |
D | GLY329 |
D | PHE330 |
D | THR331 |
D | GLN332 |
D | TYR333 |
D | GLY397 |
D | GLY442 |
D | PHE443 |
D | SHT1551 |
D | HOH2425 |
D | HOH2426 |
D | HOH2427 |
D | HOH2428 |
D | HOH2429 |
E | SER365 |
E | ILE366 |
E | TYR367 |
F | LEU117 |
F | SER118 |
F | GLY119 |
F | LYS153 |
F | SER154 |
F | VAL155 |
F | HIS156 |
F | HIS158 |
F | HOH2153 |
site_id | CC3 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE SHT D1551 |
Chain | Residue |
A | ARG225 |
A | LYS256 |
A | MHS257 |
D | ARG270 |
D | LEU320 |
D | MET324 |
D | PHE330 |
D | TYR333 |
D | PHE443 |
D | MET480 |
D | VAL482 |
D | F431550 |
D | HOH2430 |
D | HOH2431 |
D | HOH2432 |
D | HOH2433 |
D | HOH2434 |
D | HOH2435 |
E | TYR367 |
E | GLY369 |
E | HIS379 |
E | ILE380 |
site_id | CC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A1552 |
Chain | Residue |
A | SER224 |
A | LYS256 |
A | HIS262 |
A | GLU275 |
A | HOH2424 |
D | NA1558 |
D | HOH2266 |
D | HOH2432 |
site_id | CC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A1553 |
Chain | Residue |
A | ASP170 |
A | ALA173 |
A | ASP174 |
A | ASP183 |
A | ASN185 |
A | HOH2425 |
A | HOH2426 |
site_id | CC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A1554 |
Chain | Residue |
A | VAL519 |
A | LYS531 |
A | PHE537 |
A | GLU538 |
A | HOH2382 |
A | HOH2392 |
A | HOH2393 |
site_id | CC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A1555 |
Chain | Residue |
A | LYS4 |
A | ASP345 |
A | TYR348 |
A | GLU352 |
A | TYR380 |
A | HOH2008 |
site_id | CC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL B1444 |
Chain | Residue |
B | LYS3 |
B | GLU25 |
B | SER28 |
B | ARG31 |
B | GLU234 |
B | HOH2250 |
B | HOH2369 |
E | VAL95 |
site_id | CC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL C1249 |
Chain | Residue |
C | TYR109 |
C | ARG110 |
C | ASP129 |
C | HOH2134 |
C | HOH2255 |
C | HOH2256 |
C | HOH2257 |
site_id | DC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL D1552 |
Chain | Residue |
D | ASP170 |
D | ALA173 |
D | ASP174 |
D | ASP183 |
D | ASN185 |
D | HOH2203 |
D | HOH2204 |
D | HOH2436 |
site_id | DC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL D1553 |
Chain | Residue |
A | NA1557 |
A | HOH2420 |
D | SER224 |
D | LYS256 |
D | MHS257 |
D | HIS262 |
D | GLU275 |
site_id | DC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL D1554 |
Chain | Residue |
D | GLN291 |
D | ARG294 |
D | PHE513 |
D | ASP515 |
D | ASP516 |
D | PHE520 |
D | ASP521 |
D | PHE522 |
D | THR523 |
site_id | DC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL D1555 |
Chain | Residue |
D | ASP345 |
D | TYR348 |
D | GLU352 |
D | TYR380 |
site_id | DC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL E1444 |
Chain | Residue |
B | VAL95 |
E | LYS3 |
E | GLU25 |
E | SER28 |
E | ARG31 |
E | GLU234 |
E | HOH2353 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y |
Chain | Residue | Details |
C | GLN121 | |
F | GLN121 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27140643, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:1MRO, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y, ECO:0007744|PDB:5G0R |
Chain | Residue | Details |
B | GLY370 | |
E | GLY370 | |
D | TRP226 | |
D | MHS257 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: in chain B => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27140643, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:1MRO, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y, ECO:0007744|PDB:5G0R |
Chain | Residue | Details |
A | AGM271 | |
D | AGM271 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957, ECO:0007744|PDB:1HBN, ECO:0007744|PDB:1MRO, ECO:0007744|PDB:3M1V, ECO:0007744|PDB:3POT, ECO:0007744|PDB:5A0Y |
Chain | Residue | Details |
A | ALA334 | |
A | GL3445 | |
D | ALA334 | |
D | GL3445 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Pros-methylhistidine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
Chain | Residue | Details |
A | ALA258 | |
D | ALA258 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: 5-methylarginine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
Chain | Residue | Details |
A | ALA272 | |
D | ALA272 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: 2-methylglutamine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
Chain | Residue | Details |
A | ARG401 | |
D | ARG401 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: 1-thioglycine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
Chain | Residue | Details |
A | TYR446 | |
D | TYR446 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: (Z)-2,3-didehydroaspartate => ECO:0000269|PubMed:27467699 |
Chain | Residue | Details |
A | GLN451 | |
D | GLN451 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: S-methylcysteine => ECO:0000269|PubMed:10660523, ECO:0000269|PubMed:11491299, ECO:0000269|PubMed:20707311, ECO:0000269|PubMed:21438550, ECO:0000269|PubMed:27467699, ECO:0000269|PubMed:9367957 |
Chain | Residue | Details |
A | GLY453 | |
D | GLY453 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 1 |
Details | M-CSA 156 |
Chain | Residue | Details |
B | GLY368 | electrostatic stabiliser, proton acceptor, proton donor, proton relay, radical stabiliser |
A | ALA334 | electrostatic stabiliser, radical stabiliser |
A | TYR446 | single electron acceptor, single electron donor, single electron relay |
A | VAL482 | activator, electrostatic stabiliser, proton acceptor, proton donor, proton relay |
site_id | MCSA2 |
Number of Residues | 1 |
Details | M-CSA 156 |
Chain | Residue | Details |
E | GLY368 | electrostatic stabiliser, proton acceptor, proton donor, proton relay, radical stabiliser |
D | ALA334 | electrostatic stabiliser, radical stabiliser |
D | TYR446 | single electron acceptor, single electron donor, single electron relay |
D | VAL482 | activator, electrostatic stabiliser, proton acceptor, proton donor, proton relay |