1HA3
ELONGATION FACTOR TU IN COMPLEX WITH aurodox
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003746 | molecular_function | translation elongation factor activity |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006414 | biological_process | translational elongation |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 407 |
| Chain | Residue |
| A | THR25 |
| A | GDP406 |
| A | HOH2018 |
| A | HOH2043 |
| A | HOH2258 |
| A | HOH2260 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 407 |
| Chain | Residue |
| B | HOH2051 |
| B | HOH2311 |
| B | HOH2319 |
| B | THR25 |
| B | GDP406 |
| B | HOH2019 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDP A 406 |
| Chain | Residue |
| A | ASP21 |
| A | HIS22 |
| A | GLY23 |
| A | LYS24 |
| A | THR25 |
| A | THR26 |
| A | TYR47 |
| A | ASN136 |
| A | LYS137 |
| A | ASP139 |
| A | MET140 |
| A | SER174 |
| A | ALA175 |
| A | LEU176 |
| A | MG407 |
| A | HOH2083 |
| A | HOH2258 |
| A | HOH2259 |
| A | HOH2260 |
| A | HOH2261 |
| A | HOH2262 |
| A | HOH2263 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE MAU A 408 |
| Chain | Residue |
| A | ILE93 |
| A | ARG117 |
| A | LEU121 |
| A | ARG124 |
| A | GLN125 |
| A | VAL126 |
| A | TYR161 |
| A | GLU162 |
| A | TYR321 |
| A | GLU326 |
| A | GLU327 |
| A | ARG345 |
| A | ARG385 |
| A | PHE386 |
| A | ALA387 |
| A | ALA397 |
| A | HOH2077 |
| A | HOH2199 |
| A | HOH2252 |
| A | HOH2264 |
| A | HOH2265 |
| A | HOH2266 |
| A | HOH2267 |
| A | HOH2268 |
| A | HOH2269 |
| B | ARG330 |
| B | HIS331 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BME A 482 |
| Chain | Residue |
| A | VAL80 |
| A | CYS82 |
| A | PRO83 |
| A | ASN91 |
| A | MET92 |
| A | HOH2271 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE GDP B 406 |
| Chain | Residue |
| B | ASP21 |
| B | HIS22 |
| B | GLY23 |
| B | LYS24 |
| B | THR25 |
| B | THR26 |
| B | ASN136 |
| B | LYS137 |
| B | ASP139 |
| B | MET140 |
| B | SER174 |
| B | ALA175 |
| B | LEU176 |
| B | MG407 |
| B | HOH2108 |
| B | HOH2311 |
| B | HOH2312 |
| B | HOH2313 |
| B | HOH2314 |
| B | HOH2315 |
| B | HOH2316 |
| B | HOH2317 |
| B | HOH2318 |
| B | HOH2319 |
| site_id | AC7 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE MAU B 408 |
| Chain | Residue |
| B | TYR161 |
| B | GLU162 |
| B | TYR321 |
| B | GLU326 |
| B | GLU327 |
| B | ARG345 |
| B | ARG385 |
| B | PHE386 |
| B | ALA387 |
| B | ALA397 |
| B | HOH2097 |
| B | HOH2298 |
| B | HOH2307 |
| B | HOH2320 |
| B | HOH2321 |
| B | HOH2322 |
| B | HOH2323 |
| B | HOH2324 |
| B | HOH2325 |
| B | HOH2326 |
| A | ARG330 |
| A | HIS331 |
| A | HOH2201 |
| B | ILE93 |
| B | GLU118 |
| B | LEU121 |
| B | ARG124 |
| B | GLN125 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BME B 482 |
| Chain | Residue |
| B | VAL80 |
| B | CYS82 |
| B | PRO83 |
| B | ASN91 |
| B | MET92 |
| B | HOH2054 |
| B | HOH2327 |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DKapeERaRGITIntA |
| Chain | Residue | Details |
| A | ASP51-ALA66 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Region: {"description":"G1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Region: {"description":"G3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Region: {"description":"G4","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Region: {"description":"G5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11278992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C78","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V5Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V5R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V8Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00118","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2C78","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P0CE47","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | ASP21 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | ASP21 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | HIS85 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | HIS85 |
